Bussi G, Bonomi M, Gkeka P, Sattler M, Al-Hashimi HM, Auffinger P, Duca M, Foricher Y, Incarnato D, Jones AN, Kirmizialtin S, Krepl M, Orozco M, Palermo G, Pasquali S, Salmon L, Schwalbe H, Westhof E, Zacharias M (2024) RNA dynamics from experimental and computational approaches. Structure (London, England : 1993), Issue 9, Vol. 32, 1281-1287 DOI: 10.1016/j.str.2024.07.019, PubMed: 39241758 |
Martínez-Lumbreras S, Morguet C, Sattler M (2024) Dynamic interactions drive early spliceosome assembly. Current opinion in structural biology, Vol. 88, 102907 DOI: 10.1016/j.sbi.2024.102907, PubMed: 39168044 |
Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V (2024) Correction to "The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression". Nature communications, Issue 1, Vol. 15, 6632 DOI: 10.1038/s41467-024-50610-8, PubMed: 39103338 |
Liu N, O'Connor P, Gujrati V, Shelar D, Ma X, Anzenhofer P, Klemm U, Su X, Huang Y, Kleigrewe K, Feuchtinger A, Walch A, Sattler M, Plettenburg O, Ntziachristos V (2024) Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy. Journal of controlled release : official journal of the Controlled Release Society, Vol. 372, 522-530 DOI: 10.1016/j.jconrel.2024.06.037, PubMed: 38897293 |
Siebenmorgen T, Menezes F, Benassou S, Merdivan E, Didi K, Mourão ASD, Kitel R, Liò P, Kesselheim S, Piraud M, Theis FJ, Sattler M, Popowicz GM (2024) MISATO: machine learning dataset of protein-ligand complexes for structure-based drug discovery. Nature computational science, Issue 5, Vol. 4, 367-378 DOI: 10.1038/s43588-024-00627-2, PubMed: 38730184 |
Legen J, Lenzen B, Kachariya N, Feltgen S, Gao Y, Mergenthal S, Weber W, Klotzsch E, Zoschke R, Sattler M, Schmitz-Linneweber C (2024) A prion-like domain is required for phase separation and chloroplast RNA processing during cold acclimation in Arabidopsis. The Plant cell, Issue 8, Vol. 36, 2851-2872 DOI: 10.1093/plcell/koae145, PubMed: 38723165 |
Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M (2024) Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs. Nature communications, Issue 1, Vol. 15, 3888 DOI: 10.1038/s41467-024-48004-x, PubMed: 38719828 |
Proske M, Janowski R, Bacher S, Kang HS, Monecke T, Koehler T, Hutten S, Tretter J, Crois A, Molitor L, Varela-Rial A, Fino R, Donati E, De Fabritiis G, Dormann D, Sattler M, Niessing D (2024) PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. eLife, Vol. 13 DOI: 10.7554/eLife.93561, PubMed: 38655849 |
Gaussmann S, Peschel R, Ott J, Zak KM, Sastre J, Delhommel F, Popowicz GM, Boekhoven J, Schliebs W, Erdmann R, Sattler M (2024) Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif. Nature communications, Issue 1, Vol. 15, 3317 DOI: 10.1038/s41467-024-47605-w, PubMed: 38632234 |
Chen YL, Jones AN, Crawford A, Sattler M, Ettinger A, Torres-Padilla ME (2024) Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells. The Journal of cell biology, Issue 7, Vol. 223 DOI: 10.1083/jcb.202309027, PubMed: 38625077 |
Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor AJ, Couchet M, Ribicic S, Wabitsch M, Messias AC, Iuso A, Müller TD, Rydén M, Mejhert N, Krahmer N (2024) A spatiotemporal proteomic map of human adipogenesis. Nature metabolism, Issue 5, Vol. 6, 861-879 DOI: 10.1038/s42255-024-01025-8, PubMed: 38565923 |
Matsuda A, Plewka J, Rawski M, Mourão A, Zajko W, Siebenmorgen T, Kresik L, Lis K, Jones AN, Pachota M, Karim A, Hartman K, Nirwal S, Sonani R, Chykunova Y, Minia I, Mak P, Landthaler M, Nowotny M, Dubin G, Sattler M, Suder P, Popowicz GM, Pyrć K, Czarna A (2024) Despite the odds: formation of the SARS-CoV-2 methylation complex. Nucleic acids research, Issue 11, Vol. 52, 6441-6458 DOI: 10.1093/nar/gkae165, PubMed: 38499483 |
Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V (2024) The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Nature communications, Issue 1, Vol. 15, 2194 DOI: 10.1038/s41467-024-46371-z, PubMed: 38467629 |
Roca-Martínez J, Kang HS, Sattler M, Vranken W (2024) Analysis of the inter-domain orientation of tandem RRM domains with diverse linkers: connecting experimental with AlphaFold2 predicted models. NAR genomics and bioinformatics, Issue 1, Vol. 6, lqae002 DOI: 10.1093/nargab/lqae002, PubMed: 38288375 |
Lewinski M, Steffen A, Kachariya N, Elgner M, Schmal C, Messini N, Köster T, Reichel M, Sattler M, Zarnack K, Staiger D (2024) Arabidopsis thaliana GLYCINE RICH RNA-BINDING PROTEIN 7 interaction with its iCLIP target LHCB1.1 correlates with changes in RNA stability and circadian oscillation. The Plant journal : for cell and molecular biology, Issue 1, Vol. 118, 203-224 DOI: 10.1111/tpj.16601, PubMed: 38124335 |
Aretz J, Aziz M, Strohmeyer N, Sattler M, Fässler R (2023) Talin and kindlin use integrin tail allostery and direct binding to activate integrins. Nature structural & molecular biology, Issue 12, Vol. 30, 1913-1924 DOI: 10.1038/s41594-023-01139-9, PubMed: 38087085 |
Fukumura K, Sperotto L, Seuß S, Kang HS, Yoshimoto R, Sattler M, Mayeda A (2023) SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset of human short introns. Cell reports, Issue 12, Vol. 42, 113534 DOI: 10.1016/j.celrep.2023.113534, PubMed: 38065098 |
Higuera-Rodriguez RA, De Pascali MC, Aziz M, Sattler M, Rant U, Kaiser W (2023) Kinetic FRET Assay to Measure Binding-Induced Conformational Changes of Nucleic Acids. ACS sensors, Issue 12, Vol. 8, 4597-4606 DOI: 10.1021/acssensors.3c01527, PubMed: 38060303 |
Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M (2023) Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation. Nature structural & molecular biology, Issue 11, Vol. 30, 1806-1815 DOI: 10.1038/s41594-023-01136-y, PubMed: 37957306 |
Aschenbrenner I, Siebenmorgen T, Lopez A, Parr M, Ruckgaber P, Kerle A, Rührnößl F, Catici D, Haslbeck M, Frishman D, Sattler M, Zacharias M, Feige MJ (2023) Assembly-dependent Structure Formation Shapes Human Interleukin-23 versus Interleukin-12 Secretion. Journal of molecular biology, Issue 23, Vol. 435, 168300 DOI: 10.1016/j.jmb.2023.168300, PubMed: 37805067 |
Enders L, Siklos M, Borggräfe J, Gaussmann S, Koren A, Malik M, Tomek T, Schuster M, Reiniš J, Hahn E, Rukavina A, Reicher A, Casteels T, Bock C, Winter GE, Hannich JT, Sattler M, Kubicek S (2023) Pharmacological perturbation of the phase-separating protein SMNDC1. Nature communications, Issue 1, Vol. 14, 4504 DOI: 10.1038/s41467-023-40124-0, PubMed: 37587144 |
Ebersberger S, Hipp C, Mulorz MM, Buchbender A, Hubrich D, Kang HS, Martínez-Lumbreras S, Kristofori P, Sutandy FXR, Llacsahuanga Allcca L, Schönfeld J, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K, Sattler M, König J (2023) FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns. Molecular cell, Issue 15, Vol. 83, 2653-2672.e15 DOI: 10.1016/j.molcel.2023.07.002, PubMed: 37506698 |
Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M (2023) Structural basis for specific RNA recognition by the alternative splicing factor RBM5. Nature communications, Issue 1, Vol. 14, 4233 DOI: 10.1038/s41467-023-39961-w, PubMed: 37454201 |
Marciniak M, Mróz P, Napolitano V, Kalel VC, Fino R, Pykacz E, Schliebs W, Plettenburg O, Erdmann R, Sattler M, Popowicz GM, Dawidowski M (2023) Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template. European journal of medicinal chemistry, Vol. 258, 115587 DOI: 10.1016/j.ejmech.2023.115587, PubMed: 37406382 |
Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M (2023) Phase separation of FSP1 promotes ferroptosis. Nature, Issue 7969, Vol. 619, 371-377 DOI: 10.1038/s41586-023-06255-6, PubMed: 37380771 |
Calonaci N, Bernetti M, Jones A, Sattler M, Bussi G (2023) Molecular Dynamics Simulations with Grand-Canonical Reweighting Suggest Cooperativity Effects in RNA Structure Probing Experiments. Journal of chemical theory and computation, Issue 12, Vol. 19, 3672-3685 DOI: 10.1021/acs.jctc.3c00084, PubMed: 37288967 |
Svilenov HL, Delhommel F, Siebenmorgen T, Rührnößl F, Popowicz GM, Reiter A, Sattler M, Brockmeyer C, Buchner J (2023) Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2. Communications biology, Issue 1, Vol. 6, 386 DOI: 10.1038/s42003-023-04762-w, PubMed: 37031320 |
Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T (2023) Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins. Nature methods, Issue 4, Vol. 20, 523-535 DOI: 10.1038/s41592-023-01807-0, PubMed: 36973549 |
Weller M, Sattler M, Rant U (2023) Development of an aptamer-based screening for identification and characterization of novel RNA therapeutics using switchSENSE® technology. Biophysical journal, Issue 3S1, Vol. 122, 357a DOI: 10.1016/j.bpj.2022.11.1974, PubMed: 36783808 |
Roca-Martínez J, Dhondge H, Sattler M, Vranken WF (2023) Deciphering the RRM-RNA recognition code: A computational analysis. PLoS computational biology, Issue 1, Vol. 19, e1010859 DOI: 10.1371/journal.pcbi.1010859, PubMed: 36689472 |
Zanuttigh E, Derderian K, Güra MA, Geerlof A, Di Meo I, Cavestro C, Hempfling S, Ortiz-Collazos S, Mauthe M, Kmieć T, Cammarota E, Panzeri MC, Klopstock T, Sattler M, Winkelmann J, Messias AC, Iuso A (2023) Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro. Pharmaceutics, Issue 1, Vol. 15 DOI: 10.3390/pharmaceutics15010267, PubMed: 36678896 |
Delhommel F, Martínez-Lumbreras S, Sattler M (2023) Combining NMR, SAXS and SANS to characterize the structure and dynamics of protein complexes. Methods in enzymology, Vol. 678, 263-297 DOI: 10.1016/bs.mie.2022.09.020, PubMed: 36641211 |
Keil P, Wulf A, Kachariya N, Reuscher S, Hühn K, Silbern I, Altmüller J, Keller M, Stehle R, Zarnack K, Sattler M, Urlaub H, Sträßer K (2023) Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA. Nucleic acids research, Issue 2, Vol. 51, 831-851 DOI: 10.1093/nar/gkac1206, PubMed: 36583366 |
Chora AF, Pedroso D, Kyriakou E, Pejanovic N, Colaço H, Gozzelino R, Barros A, Willmann K, Velho T, Moita CF, Santos I, Pereira P, Carvalho S, Martins FB, Ferreira JA, de Almeida SF, Benes V, Anrather J, Weis S, Soares MP, Geerlof A, Neefjes J, Sattler M, Messias AC, Neves-Costa A, Moita LF (2022) DNA damage independent inhibition of NF-κB transcription by anthracyclines. eLife, Vol. 11 DOI: 10.7554/eLife.77443, PubMed: 36476511 |
Gopalswamy M, Zheng C, Gaussmann S, Kooshapur H, Hambruch E, Schliebs W, Erdmann R, Antes I, Sattler M (2023) Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14. Biological chemistry, Issue 2-3, Vol. 404, 179-194 DOI: 10.1515/hsz-2022-0177, PubMed: 36437542 |
Narayanan D, Tran KT, Pallesen JS, Solbak SMØ, Qin Y, Mukminova E, Luchini M, Vasilyeva KO, González Chichón D, Goutsiou G, Poulsen C, Haapanen N, Popowicz GM, Sattler M, Olagnier D, Gajhede M, Bach A (2022) Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. Journal of medicinal chemistry, Issue 21, Vol. 65, 14481-14526 DOI: 10.1021/acs.jmedchem.2c00830, PubMed: 36263945 |
Napolitano V, Mróz P, Marciniak M, Kalel VC, Softley CA, Janna Olmos JD, Tippler BG, Schorpp K, Rioton S, Fröhlich T, Plettenburg O, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dawidowski M, Dubin G (2022) Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma. European journal of medicinal chemistry, Vol. 243, 114778 DOI: 10.1016/j.ejmech.2022.114778, PubMed: 36194937 |
Napolitano V, Softley CA, Blat A, Kalel VC, Schorpp K, Siebenmorgen T, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dubin G (2022) Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma. Scientific reports, Issue 1, Vol. 12, 14705 DOI: 10.1038/s41598-022-18841-1, PubMed: 36038611 |
Jones AN, Graß C, Meininger I, Geerlof A, Klostermann M, Zarnack K, Krappmann D, Sattler M (2022) Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1. Science advances, Issue 31, Vol. 8, eabp9153 DOI: 10.1126/sciadv.abp9153, PubMed: 35921415 |
Nguyen A, Gemmecker G, Softley CA, Movsisyan LD, Pfaffeneder T, Heine A, Reuter K, Diederich F, Sattler M, Klebe G (2022) 19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase. ACS chemical biology, Issue 7, Vol. 17, 1745-1755 DOI: 10.1021/acschembio.2c00080, PubMed: 35763700 |
Jones AN, Walbrun A, Falleroni F, Rief M, Sattler M (2022) Conformational Effects of a Cancer-Linked Mutation in Pri-miR-30c RNA. Journal of molecular biology, Issue 18, Vol. 434, 167705 DOI: 10.1016/j.jmb.2022.167705, PubMed: 35760371 |
Jones AN, Mourão A, Czarna A, Matsuda A, Fino R, Pyrc K, Sattler M, Popowicz GM (2022) Characterization of SARS-CoV-2 replication complex elongation and proofreading activity. Scientific reports, Issue 1, Vol. 12, 9593 DOI: 10.1038/s41598-022-13380-1, PubMed: 35688849 |
Jussupow A, Lopez A, Baumgart M, Mader SL, Sattler M, Kaila VRI (2022) Extended conformational states dominate the Hsp90 chaperone dynamics. The Journal of biological chemistry, Issue 7, Vol. 298, 102101 DOI: 10.1016/j.jbc.2022.102101, PubMed: 35667441 |
Jones AN, Tikhaia E, Mourão A, Sattler M (2022) Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1. Nucleic acids research, Issue 4, Vol. 50, 2350-2362 DOI: 10.1093/nar/gkac080, PubMed: 35166835 |
Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, Kampmann M, Lamb DC, Rosenzweig R, Sattler M, Buchner J (2022) NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Molecular cell, Issue 3, Vol. 82, 555-569.e7 DOI: 10.1016/j.molcel.2021.12.031, PubMed: 35063133 |
Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hölscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Slysz K, Szczepanski A, Greve-Isdahl Mohn K, Blomberg B, Sattler M, Hadian K, Popowicz GM, Pyrc K (2022) Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell chemical biology, Issue 5, Vol. 29, 774-784.e8 DOI: 10.1016/j.chembiol.2021.11.006, PubMed: 35021060 |
Li M, Gaussmann S, Tippler B, Ott J, Popowicz GM, Schliebs W, Sattler M, Erdmann R, Kalel VC (2021) Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction. Frontiers in cell and developmental biology, Vol. 9, 737159 DOI: 10.3389/fcell.2021.737159, PubMed: 34988071 |
Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, Rutz D, Blair L, Buchner J, Sattler M (2021) Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network. Science advances, Issue 51, Vol. 7, eabl7295 DOI: 10.1126/sciadv.abl7295, PubMed: 34919431 |
Bernaudat F, Gustems M, Günther J, Oliva MF, Buschle A, Göbel C, Pagniez P, Lupo J, Signor L, Müller CW, Morand P, Sattler M, Hammerschmidt W, Petosa C (2022) Structural basis of DNA methylation-dependent site selectivity of the Epstein-Barr virus lytic switch protein ZEBRA/Zta/BZLF1. Nucleic acids research, Issue 1, Vol. 50, 490-511 DOI: 10.1093/nar/gkab1183, PubMed: 34893887 |
Heumüller AW, Jones AN, Mourão A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly-Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jaé N, Sattler M, Dimmeler S (2022) Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses. Circulation research, Issue 1, Vol. 130, 67-79 DOI: 10.1161/CIRCRESAHA.121.320029, PubMed: 34789007 |
Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, Sattler M, Prabu JR, Sidhu SS, Schulman BA (2022) Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. Journal of molecular biology, Issue 2, Vol. 434, 167347 DOI: 10.1016/j.jmb.2021.167347, PubMed: 34767800 |
Fottner M, Weyh M, Gaussmann S, Schwarz D, Sattler M, Lang K (2021) A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes. Nature communications, Issue 1, Vol. 12, 6515 DOI: 10.1038/s41467-021-26812-9, PubMed: 34764289 |
Ghosh D, Koch U, Hadian K, Sattler M, Tetko IV (2022) Highly Accurate Filters to Flag Frequent Hitters in AlphaScreen Assays by Suggesting their Mechanism. Molecular informatics, Issue 3, Vol. 41, e2100151 DOI: 10.1002/minf.202100151, PubMed: 34676998 |
Zhang X, Schuhmachers P, Mourão A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck SM, Hammerschmidt W, Küppers R, Kuster B, Raab M, Strebhardt K, Sattler M, Münz C, Kempkes B (2021) PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice. EMBO reports, Issue 12, Vol. 22, e53007 DOI: 10.15252/embr.202153007, PubMed: 34605140 |
Fino R, Lenhart D, Kalel VC, Softley CA, Napolitano V, Byrne R, Schliebs W, Dawidowski M, Erdmann R, Sattler M, Schneider G, Plettenburg O, Popowicz GM (2021) Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents. Journal of chemical information and modeling, Issue 10, Vol. 61, 5256-5268 DOI: 10.1021/acs.jcim.1c00472, PubMed: 34597510 |
Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P (2021) Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold. International journal of pharmaceutics, Vol. 607, 121043 DOI: 10.1016/j.ijpharm.2021.121043, PubMed: 34450223 |
Fukumura K, Yoshimoto R, Sperotto L, Kang HS, Hirose T, Inoue K, Sattler M, Mayeda A (2021) SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns. Nature communications, Issue 1, Vol. 12, 4910 DOI: 10.1038/s41467-021-24879-y, PubMed: 34389706 |
Reyes Romero A, Lunev S, Popowicz GM, Calderone V, Gentili M, Sattler M, Plewka J, Taube M, Kozak M, Holak TA, Dömling ASS, Groves MR (2021) A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity. Communications biology, Issue 1, Vol. 4, 949 DOI: 10.1038/s42003-021-02442-1, PubMed: 34376783 |
de Souza Degenhardt MF, Vitale PAM, Abiko LA, Zacharias M, Sattler M, Oliveira CLP, Salinas RK (2021) Molecular insights on CALX-CBD12 interdomain dynamics from MD simulations, RDCs, and SAXS. Biophysical journal, Issue 17, Vol. 120, 3664-3675 DOI: 10.1016/j.bpj.2021.07.022, PubMed: 34310942 |
Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mourão A, Klepac K, Bühler L, Alfaro AJ, Kaczmarek I, Linford A, Bosma M, Shilkova O, Ritvos O, Nakamura N, Hirose S, Lassi M, Teperino R, Machado J, Scheideler M, Dietrich A, Geerlof A, Feuchtinger A, Blutke A, Fischer K, Müller TD, Kessler K, Schöneberg T, Thor D, Hornemann S, Kruse M, Nawroth P, Pivovarova-Ramich O, Pfeiffer AFH, Sattler M, Blüher M, Herzig S (2021) Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nature communications, Issue 1, Vol. 12, 2999 DOI: 10.1038/s41467-021-22579-1, PubMed: 34016966 |
Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U (2021) Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20. EMBO reports, Issue 6, Vol. 22, e49568 DOI: 10.15252/embr.201949568, PubMed: 33969602 |
Liu N, Gujrati V, Malekzadeh-Najafabadi J, Werner JPF, Klemm U, Tang L, Chen Z, Prakash J, Huang Y, Stiel A, Mettenleiter G, Aichler M, Blutke A, Walch A, Kleigrewe K, Razansky D, Sattler M, Ntziachristos V (2021) Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors. Photoacoustics, Vol. 22, 100263 DOI: 10.1016/j.pacs.2021.100263, PubMed: 33948433 |
Gaussmann S, Gopalswamy M, Eberhardt M, Reuter M, Zou P, Schliebs W, Erdmann R, Sattler M (2021) Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14. Frontiers in cell and developmental biology, Vol. 9, 651449 DOI: 10.3389/fcell.2021.651449, PubMed: 33937250 |
Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A (2021) Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds. Journal of medicinal chemistry, Issue 8, Vol. 64, 4623-4661 DOI: 10.1021/acs.jmedchem.0c02094, PubMed: 33818106 |
Munshaw S, Bruche S, Redpath AN, Jones A, Patel J, Dubé KN, Lee R, Hester SS, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon KM, Smart N (2021) Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling. The Journal of clinical investigation, Issue 10, Vol. 131, e127884 DOI: 10.1172/JCI127884, PubMed: 33784254 |
Liu N, O'Connor P, Gujrati V, Gorpas D, Glasl S, Blutke A, Walch A, Kleigrewe K, Sattler M, Plettenburg O, Ntziachristos V (2021) Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy. Advanced healthcare materials, Issue 9, Vol. 10, e2002115 DOI: 10.1002/adhm.202002115, PubMed: 33738974 |
Schuch LA, Forstner M, Rapp CK, Li Y, Smith DEC, Mendes MI, Delhommel F, Sattler M, Emiralioğlu N, Taskiran EZ, Orhan D, Kiper N, Rohlfs M, Jeske T, Hastreiter M, Gerstlauer M, Torrent-Vernetta A, Moreno-Galdó A, Kammer B, Brasch F, Reu-Hofer S, Griese M (2021) FARS1-related disorders caused by bi-allelic mutations in cytosolic phenylalanyl-tRNA synthetase genes: Look beyond the lungs! Clinical genetics, Issue 6, Vol. 99, 789-801 DOI: 10.1111/cge.13943, PubMed: 33598926 |
Calonaci N, Jones A, Cuturello F, Sattler M, Bussi G (2020) Machine learning a model for RNA structure prediction. NAR genomics and bioinformatics, Issue 4, Vol. 2, lqaa090 DOI: 10.1093/nargab/lqaa090, PubMed: 33575634 |
Biebl MM, Lopez A, Rehn A, Freiburger L, Lawatscheck J, Blank B, Sattler M, Buchner J (2021) Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle. Nature communications, Issue 1, Vol. 12, 828 DOI: 10.1038/s41467-021-21063-0, PubMed: 33547294 |
Kang HS, Sattler M (2018) Capturing dynamic conformational shifts in protein-ligand recognition using integrative structural biology in solution. Emerging topics in life sciences, Issue 1, Vol. 2, 107-119 DOI: 10.1042/ETLS20170090, PubMed: 33525784 |
Reuter M, Kooshapur H, Suda JG, Gaussmann S, Neuhaus A, Brühl L, Bharti P, Jung M, Schliebs W, Sattler M, Erdmann R (2021) Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility. Journal of molecular biology, Issue 5, Vol. 433, 166765 DOI: 10.1016/j.jmb.2020.166765, PubMed: 33484719 |
Savitskiy S, Wachtel R, Pourjafar-Dehkordi D, Kang HS, Trauschke V, Lamb DC, Sattler M, Zacharias M, Itzen A (2021) Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation. iScience, Issue 1, Vol. 24, 101940 DOI: 10.1016/j.isci.2020.101940, PubMed: 33426511 |
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA (2021) Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature chemical biology, Issue 3, Vol. 17, 272-279 DOI: 10.1038/s41589-020-00696-0, PubMed: 33288957 |
Jagtap PKA, Kubelka T, Soni K, Will CL, Garg D, Sippel C, Kapp TG, Potukuchi HK, Schorpp K, Hadian K, Kessler H, Lührmann R, Hausch F, Bach T, Sattler M (2020) Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly. Nature communications, Issue 1, Vol. 11, 5621 DOI: 10.1038/s41467-020-19514-1, PubMed: 33159082 |
López A, Elimelech AR, Klimm K, Sattler M (2021) The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90. Chembiochem : a European journal of chemical biology, Issue 6, Vol. 22, 1084-1092 DOI: 10.1002/cbic.202000699, PubMed: 33147371 |
Donau C, Späth F, Sosson M, Kriebisch BAK, Schnitter F, Tena-Solsona M, Kang HS, Salibi E, Sattler M, Mutschler H, Boekhoven J (2020) Active coacervate droplets as a model for membraneless organelles and protocells. Nature communications, Issue 1, Vol. 11, 5167 DOI: 10.1038/s41467-020-18815-9, PubMed: 33056997 |
Jussupow A, Messias AC, Stehle R, Geerlof A, Solbak SMØ, Paissoni C, Bach A, Sattler M, Camilloni C (2020) The dynamics of linear polyubiquitin. Science advances, Issue 42, Vol. 6 DOI: 10.1126/sciadv.abc3786, PubMed: 33055165 |
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, Hundelshausen PV, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020) Autophagy unleashes noncanonical microRNA functions. Autophagy, Issue 12, Vol. 16, 2294-2296 DOI: 10.1080/15548627.2020.1830523, PubMed: 33054575 |
Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P (2021) Albumin-binding domain extends half-life of glucagon-like peptide-1. European journal of pharmacology, Vol. 890, 173650 DOI: 10.1016/j.ejphar.2020.173650, PubMed: 33049303 |
Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J (2020) DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease. Molecular cell, Issue 1, Vol. 80, 102-113.e6 DOI: 10.1016/j.molcel.2020.08.003, PubMed: 32853547 |
Delhommel F, Sattler M (2020) When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats. Structure (London, England : 1993), Issue 7, Vol. 28, 730-732 DOI: 10.1016/j.str.2020.06.005, PubMed: 32640252 |
Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM (2020) Correction for Softley et al., "Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase". Antimicrobial agents and chemotherapy, Issue 7, Vol. 64 DOI: 10.1128/AAC.01077-20, PubMed: 32576598 |
Softley CA, Bostock MJ, Popowicz GM, Sattler M (2020) Paramagnetic NMR in drug discovery. Journal of biomolecular NMR, Issue 6-7, Vol. 74, 287-309 DOI: 10.1007/s10858-020-00322-0, PubMed: 32524233 |
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020) Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Science translational medicine, Issue 546, Vol. 12 DOI: 10.1126/scitranslmed.aaz2294, PubMed: 32493793 |
Soni K, Martínez-Lumbreras S, Sattler M (2020) Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5. Journal of molecular biology, Issue 14, Vol. 432, 4127-4138 DOI: 10.1016/j.jmb.2020.05.012, PubMed: 32450081 |
Su W, Tan H, Janowski R, Zhang W, Wang P, Zhang J, Zhai H, Li J, Niessing D, Sattler M, Zou P (2020) Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics. Molecular pharmaceutics, Issue 5, Vol. 17, 1663-1673 DOI: 10.1021/acs.molpharmaceut.0c00098, PubMed: 32243177 |
Vieweg S, Mulholland K, Bräuning B, Kachariya N, Lai YC, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK (2020) PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72. The Biochemical journal, Issue 9, Vol. 477, 1651-1668 DOI: 10.1042/BCJ20190664, PubMed: 32227113 |
Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM (2020) Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase. Antimicrobial agents and chemotherapy, Issue 6, Vol. 64, e00123-20 DOI: 10.1128/AAC.00123-20, PubMed: 32205343 |
Delhommel F, Gabel F, Sattler M (2020) Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes. Journal of molecular biology, Issue 9, Vol. 432, 2890-2912 DOI: 10.1016/j.jmb.2020.03.014, PubMed: 32199983 |
Ratkova EL, Dawidowski M, Napolitano V, Dubin G, Fino R, Ostertag MS, Sattler M, Popowicz G, Tetko IV (2020) Water envelope has a critical impact on the design of protein-protein interaction inhibitors. Chemical communications (Cambridge, England), Issue 31, Vol. 56, 4360-4363 DOI: 10.1039/c9cc07714f, PubMed: 32195483 |
Kang HS, Sánchez-Rico C, Ebersberger S, Sutandy FXR, Busch A, Welte T, Stehle R, Hipp C, Schulz L, Buchbender A, Zarnack K, König J, Sattler M (2020) An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2. Proceedings of the National Academy of Sciences of the United States of America, Issue 13, Vol. 117, 7140-7149 DOI: 10.1073/pnas.1913483117, PubMed: 32188783 |
Mader SL, Lopez A, Lawatscheck J, Luo Q, Rutz DA, Gamiz-Hernandez AP, Sattler M, Buchner J, Kaila VRI (2020) Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90. Nature communications, Issue 1, Vol. 11, 1410 DOI: 10.1038/s41467-020-15050-0, PubMed: 32179743 |
De Angelis M, Schriever SC, Kyriakou E, Sattler M, Messias AC, Schramm KW, Pfluger PT (2020) Detection and quantification of the anti-obesity drug celastrol in murine liver and brain. Neurochemistry international, Vol. 136, 104713 DOI: 10.1016/j.neuint.2020.104713, PubMed: 32151623 |
Barthelmes K, Ramcke E, Kang HS, Sattler M, Itzen A (2020) Conformational control of small GTPases by AMPylation. Proceedings of the National Academy of Sciences of the United States of America, Issue 11, Vol. 117, 5772-5781 DOI: 10.1073/pnas.1917549117, PubMed: 32123090 |
Denis M, Softley C, Giuntini S, Gentili M, Ravera E, Parigi G, Fragai M, Popowicz G, Sattler M, Luchinat C, Cerofolini L, Nativi C (2020) The Photocatalyzed Thiol-ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins. Chemphyschem : a European journal of chemical physics and physical chemistry, Issue 9, Vol. 21, 863-869 DOI: 10.1002/cphc.202000071, PubMed: 32092218 |
Göttlicher M, Sattler M, Brönstrup M (2020) New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC). ChemMedChem, Issue 5, Vol. 15, 468-470 DOI: 10.1002/cmdc.202000019, PubMed: 32080972 |
Solbak SMØ, Zang J, Narayanan D, Høj LJ, Bucciarelli S, Softley C, Meier S, Langkilde AE, Gotfredsen CH, Sattler M, Bach A (2020) Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. Journal of medicinal chemistry, Issue 3, Vol. 63, 1156-1177 DOI: 10.1021/acs.jmedchem.9b01492, PubMed: 31922756 |
Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B (2020) Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action. Angewandte Chemie (International ed. in English), Issue 14, Vol. 59, 5771-5781 DOI: 10.1002/anie.201914559, PubMed: 31863711 |
Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM (2020) Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity. Journal of medicinal chemistry, Issue 2, Vol. 63, 847-879 DOI: 10.1021/acs.jmedchem.9b01876, PubMed: 31860309 |
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M (2019) FSP1 is a glutathione-independent ferroptosis suppressor. Nature, Issue 7784, Vol. 575, 693-698 DOI: 10.1038/s41586-019-1707-0, PubMed: 31634899 |
Jagtap PKA, Asami S, Sippel C, Kaila VRI, Hausch F, Sattler M (2019) Corrigendum: Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States. Angewandte Chemie (International ed. in English), Issue 39, Vol. 58, 13619 DOI: 10.1002/anie.201908888, PubMed: 31549791 |
Meier S, Bohnacker S, Klose CJ, Lopez A, Choe CA, Schmid PWN, Bloemeke N, Rührnößl F, Haslbeck M, Bieren JE, Sattler M, Huang PS, Feige MJ (2019) The molecular basis of chaperone-mediated interleukin 23 assembly control. Nature communications, Issue 1, Vol. 10, 4121 DOI: 10.1038/s41467-019-12006-x, PubMed: 31511508 |
Girstmair H, Tippel F, Lopez A, Tych K, Stein F, Haberkant P, Schmid PWN, Helm D, Rief M, Sattler M, Buchner J (2019) The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range. Nature communications, Issue 1, Vol. 10, 3626 DOI: 10.1038/s41467-019-11518-w, PubMed: 31399574 |
Kalel VC, Li M, Gaussmann S, Delhommel F, Schäfer AB, Tippler B, Jung M, Maier R, Oeljeklaus S, Schliebs W, Warscheid B, Sattler M, Erdmann R (2019) Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites. Biochimica et biophysica acta. Molecular cell research, Issue 12, Vol. 1866, 118520 DOI: 10.1016/j.bbamcr.2019.07.015, PubMed: 31369765 |
Lingaraju M, Johnsen D, Schlundt A, Langer LM, Basquin J, Sattler M, Heick Jensen T, Falk S, Conti E (2019) The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nature communications, Issue 1, Vol. 10, 3393 DOI: 10.1038/s41467-019-11339-x, PubMed: 31358741 |
Jones AN, Sattler M (2019) Challenges and perspectives for structural biology of lncRNAs-the example of the Xist lncRNA A-repeats. Journal of molecular cell biology, Issue 10, Vol. 11, 845-859 DOI: 10.1093/jmcb/mjz086, PubMed: 31336384 |
Kinting S, Li Y, Forstner M, Delhommel F, Sattler M, Griese M (2019) Potentiation of ABCA3 lipid transport function by ivacaftor and genistein. Journal of cellular and molecular medicine, Issue 8, Vol. 23, 5225-5234 DOI: 10.1111/jcmm.14397, PubMed: 31210424 |
von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E (2019) Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. The Journal of experimental medicine, Issue 7, Vol. 216, 1700-1723 DOI: 10.1084/jem.20181762, PubMed: 31126966 |
Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A (2019) Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3. Nature communications, Issue 1, Vol. 10, 2266 DOI: 10.1038/s41467-019-09769-8, PubMed: 31118463 |
Jagtap PKA, Asami S, Sippel C, Kaila VRI, Hausch F, Sattler M (2019) Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States. Angewandte Chemie (International ed. in English), Issue 28, Vol. 58, 9429-9433 DOI: 10.1002/anie.201902994, PubMed: 31100184 |
Tripsianes K, Schütz U, Emmanouilidis L, Gemmecker G, Sattler M (2019) Selective isotope labeling for NMR structure determination of proteins in complex with unlabeled ligands. Journal of biomolecular NMR, Issue 3-4, Vol. 73, 183-189 DOI: 10.1007/s10858-019-00241-9, PubMed: 31041647 |
Ostertag MS, Hutwelker W, Plettenburg O, Sattler M, Popowicz GM (2019) Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants. Journal of molecular biology, Issue 11, Vol. 431, 2213-2221 DOI: 10.1016/j.jmb.2019.04.017, PubMed: 31026449 |
Heber S, Gáspár I, Tants JN, Günther J, Moya SMF, Janowski R, Ephrussi A, Sattler M, Niessing D (2019) Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains. Nature communications, Issue 1, Vol. 10, 1659 DOI: 10.1038/s41467-019-09655-3, PubMed: 30971701 |
Pabis M, Corsini L, Vincendeau M, Tripsianes K, Gibson TJ, Brack-Werner R, Sattler M (2019) Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors. Nucleic acids research, Issue 9, Vol. 47, 4859-4871 DOI: 10.1093/nar/gkz185, PubMed: 30892606 |
Schopf FH, Huber EM, Dodt C, Lopez A, Biebl MM, Rutz DA, Mühlhofer M, Richter G, Madl T, Sattler M, Groll M, Buchner J (2019) The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2. Molecular cell, Issue 1, Vol. 74, 73-87.e8 DOI: 10.1016/j.molcel.2019.02.011, PubMed: 30876805 |
Tan H, Su W, Zhang W, Wang P, Sattler M, Zou P (2018) Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins. Current pharmaceutical design, Issue 41, Vol. 24, 4932-4946 DOI: 10.2174/1381612825666190206105232, PubMed: 30727869 |
Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT (2019) Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465. Diabetes, Issue 3, Vol. 68, 676 DOI: 10.2337/db19-er03a, PubMed: 30635274 |
Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J (2019) Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. The EMBO journal, Issue 2, Vol. 38, e99876 DOI: 10.15252/embj.201899876, PubMed: 30530478 |
Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC (2018) Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus. Journal of medicinal chemistry, Issue 24, Vol. 61, 11144-11157 DOI: 10.1021/acs.jmedchem.8b01224, PubMed: 30525586 |
Kalel VC, Mäser P, Sattler M, Erdmann R, Popowicz GM (2018) Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development. Current opinion in microbiology, Vol. 46, 116-122 DOI: 10.1016/j.mib.2018.11.003, PubMed: 30481613 |
Ostertag MS, Messias AC, Sattler M, Popowicz GM (2019) The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation. Structure (London, England : 1993), Issue 2, Vol. 27, 327-334.e3 DOI: 10.1016/j.str.2018.10.005, PubMed: 30449689 |
Pabis M, Popowicz GM, Stehle R, Fernández-Ramos D, Asami S, Warner L, García-Mauriño SM, Schlundt A, Martínez-Chantar ML, Díaz-Moreno I, Sattler M (2019) HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs. Nucleic acids research, Issue 2, Vol. 47, 1011-1029 DOI: 10.1093/nar/gky1138, PubMed: 30418581 |
Harrison L, Schriever SC, Feuchtinger A, Kyriakou E, Baumann P, Pfuhlmann K, Messias AC, Walch A, Tschöp MH, Pfluger PT (2019) Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice. International journal of obesity (2005), Issue 6, Vol. 43, 1305-1318 DOI: 10.1038/s41366-018-0221-z, PubMed: 30283080 |
Essig K, Kronbeck N, Guimaraes JC, Lohs C, Schlundt A, Hoffmann A, Behrens G, Brenner S, Kowalska J, Lopez-Rodriguez C, Jemielity J, Holtmann H, Reiche K, Hackermüller J, Sattler M, Zavolan M, Heissmeyer V (2018) Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation. Nature communications, Issue 1, Vol. 9, 3810 DOI: 10.1038/s41467-018-06184-3, PubMed: 30232334 |
Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT (2018) Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes, Issue 11, Vol. 67, 2456-2465 DOI: 10.2337/db18-0146, PubMed: 30158241 |
Brenke JK, Popowicz GM, Schorpp K, Rothenaigner I, Roesner M, Meininger I, Kalinski C, Ringelstetter L, R'kyek O, Jürjens G, Vincendeau M, Plettenburg O, Sattler M, Krappmann D, Hadian K (2018) Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity. The Journal of biological chemistry, Issue 34, Vol. 293, 13191-13203 DOI: 10.1074/jbc.RA118.002649, PubMed: 29950522 |
Kooshapur H, Choudhury NR, Simon B, Mühlbauer M, Jussupow A, Fernandez N, Jones AN, Dallmann A, Gabel F, Camilloni C, Michlewski G, Caceres JF, Sattler M (2018) Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1. Nature communications, Issue 1, Vol. 9, 2479 DOI: 10.1038/s41467-018-04871-9, PubMed: 29946118 |
Iuso A, Wiersma M, Schüller HJ, Pode-Shakked B, Marek-Yagel D, Grigat M, Schwarzmayr T, Berutti R, Alhaddad B, Kanon B, Grzeschik NA, Okun JG, Perles Z, Salem Y, Barel O, Vardi A, Rubinshtein M, Tirosh T, Dubnov-Raz G, Messias AC, Terrile C, Barshack I, Volkov A, Avivi C, Eyal E, Mastantuono E, Kumbar M, Abudi S, Braunisch M, Strom TM, Meitinger T, Hoffmann GF, Prokisch H, Haack TB, Brundel BJJM, Haas D, Sibon OCM, Anikster Y (2018) Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. American journal of human genetics, Issue 6, Vol. 102, 1018-1030 DOI: 10.1016/j.ajhg.2018.03.022, PubMed: 29754768 |
Ghosh D, Koch U, Hadian K, Sattler M, Tetko IV (2018) Luciferase Advisor: High-Accuracy Model To Flag False Positive Hits in Luciferase HTS Assays. Journal of chemical information and modeling, Issue 5, Vol. 58, 933-942 DOI: 10.1021/acs.jcim.7b00574, PubMed: 29667823 |
Rutz DA, Luo Q, Freiburger L, Madl T, Kaila VRI, Sattler M, Buchner J (2018) A switch point in the molecular chaperone Hsp90 responding to client interaction. Nature communications, Issue 1, Vol. 9, 1472 DOI: 10.1038/s41467-018-03946-x, PubMed: 29662162 |
Sutandy FXR, Ebersberger S, Huang L, Busch A, Bach M, Kang HS, Fallmann J, Maticzka D, Backofen R, Stadler PF, Zarnack K, Sattler M, Legewie S, König J (2018) In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors. Genome research, Issue 5, Vol. 28, 699-713 DOI: 10.1101/gr.229757.117, PubMed: 29643205 |
Tomala MD, Magiera-Mularz K, Kubica K, Krzanik S, Zieba B, Musielak B, Pustula M, Popowicz GM, Sattler M, Dubin G, Skalniak L, Holak TA (2018) Identification of small-molecule inhibitors of USP2a. European journal of medicinal chemistry, Vol. 150, 261-267 DOI: 10.1016/j.ejmech.2018.03.009, PubMed: 29529503 |
Asami S, Kallies W, Günther JC, Stavropoulou M, Glaser SJ, Sattler M (2018) Ultrashort Broadband Cooperative Pulses for Multidimensional Biomolecular NMR Experiments. Angewandte Chemie (International ed. in English), Issue 44, Vol. 57, 14498-14502 DOI: 10.1002/anie.201800220, PubMed: 29508496 |
Colaluca IN, Basile A, Freiburger L, D'Uva V, Disalvatore D, Vecchi M, Confalonieri S, Tosoni D, Cecatiello V, Malabarba MG, Yang CJ, Kainosho M, Sattler M, Mapelli M, Pece S, Di Fiore PP (2018) A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer. The Journal of cell biology, Issue 2, Vol. 217, 745-762 DOI: 10.1083/jcb.201709092, PubMed: 29269425 |
Tants JN, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, Juen M, Hartlmüller C, Böttcher R, Kunzelmann S, Lange O, Kreutz C, Förstemann K, Sattler M (2017) Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic acids research, Issue 21, Vol. 45, 12536-12550 DOI: 10.1093/nar/gkx886, PubMed: 29040648 |
Supekar S, Papageorgiou AC, Gemmecker G, Peltzer R, Johansson MP, Tripsianes K, Sattler M, Kaila VRI (2018) Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain. Angewandte Chemie (International ed. in English), Issue 2, Vol. 57, 486-490 DOI: 10.1002/anie.201708233, PubMed: 28980372 |
Falk S, Tants JN, Basquin J, Thoms M, Hurt E, Sattler M, Conti E (2017) Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53. RNA (New York, N.Y.), Issue 12, Vol. 23, 1780-1787 DOI: 10.1261/rna.062901.117, PubMed: 28883156 |
Stiegler SC, Rübbelke M, Korotkov VS, Weiwad M, John C, Fischer G, Sieber SA, Sattler M, Buchner J (2017) A chemical compound inhibiting the Aha1-Hsp90 chaperone complex. The Journal of biological chemistry, Issue 41, Vol. 292, 17073-17083 DOI: 10.1074/jbc.M117.797829, PubMed: 28851842 |
Tan H, Su W, Wang P, Zhang W, Sattler M, Zou P (2017) Expression and purification of a difficult sarcomeric protein: Telethonin. Protein expression and purification, Vol. 140, 74-80 DOI: 10.1016/j.pep.2017.08.007, PubMed: 28811266 |
Sánchez-Rico C, Voith von Voithenberg L, Warner L, Lamb DC, Sattler M (2017) Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany), Issue 57, Vol. 23, 14267-14277 DOI: 10.1002/chem.201702423, PubMed: 28799205 |
Hartlmüller C, Günther JC, Wolter AC, Wöhnert J, Sattler M, Madl T (2017) RNA structure refinement using NMR solvent accessibility data. Scientific reports, Issue 1, Vol. 7, 5393 DOI: 10.1038/s41598-017-05821-z, PubMed: 28710477 |
Kalel VC, Emmanouilidis L, Dawidowski M, Schliebs W, Sattler M, Popowicz GM, Erdmann R (2017) Inhibitors of glycosomal protein import provide new leads against trypanosomiasis. Microbial cell (Graz, Austria), Issue 7, Vol. 4, 229-232 DOI: 10.15698/mic2017.07.581, PubMed: 28706938 |
Sonntag M, Jagtap PKA, Simon B, Appavou MS, Geerlof A, Stehle R, Gabel F, Hennig J, Sattler M (2017) Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins. Angewandte Chemie (International ed. in English), Issue 32, Vol. 56, 9322-9325 DOI: 10.1002/anie.201702904, PubMed: 28636238 |
Schlundt A, Buchner S, Janowski R, Heydenreich T, Heermann R, Lassak J, Geerlof A, Stehle R, Niessing D, Jung K, Sattler M (2017) Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator. Scientific reports, Issue 1, Vol. 7, 1051 DOI: 10.1038/s41598-017-01031-9, PubMed: 28432336 |
Schlundt A, Tants JN, Sattler M (2017) Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition. Methods (San Diego, Calif.), Vol. 118-119, 119-136 DOI: 10.1016/j.ymeth.2017.03.015, PubMed: 28315749 |
Emmanouilidis L, Schütz U, Tripsianes K, Madl T, Radke J, Rucktäschel R, Wilmanns M, Schliebs W, Erdmann R, Sattler M (2017) Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19. Nature communications, Vol. 8, 14635 DOI: 10.1038/ncomms14635, PubMed: 28281558 |
Edelmann FT, Schlundt A, Heym RG, Jenner A, Niedner-Boblenz A, Syed MI, Paillart JC, Stehle R, Janowski R, Sattler M, Jansen RP, Niessing D (2017) Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex. Nature structural & molecular biology, Issue 2, Vol. 24, 152-161 DOI: 10.1038/nsmb.3351, PubMed: 28092367 |
Mourão A, Bonnal S, Soni K, Warner L, Bordonné R, Valcárcel J, Sattler M (2016) Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation. eLife, Vol. 5 DOI: 10.7554/eLife.14707, PubMed: 27894420 |
Voith von Voithenberg L, Sánchez-Rico C, Kang HS, Madl T, Zanier K, Barth A, Warner LR, Sattler M, Lamb DC (2016) Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift. Proceedings of the National Academy of Sciences of the United States of America, Issue 46, Vol. 113, E7169-E7175 DOI: 10.1073/pnas.1605873113, PubMed: 27799531 |
Jagtap PK, Garg D, Kapp TG, Will CL, Demmer O, Lührmann R, Kessler H, Sattler M (2016) Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing. Journal of medicinal chemistry, Issue 22, Vol. 59, 10190-10197 DOI: 10.1021/acs.jmedchem.6b01118, PubMed: 27753493 |
Zierer BK, Rübbelke M, Tippel F, Madl T, Schopf FH, Rutz DA, Richter K, Sattler M, Buchner J (2016) Importance of cycle timing for the function of the molecular chaperone Hsp90. Nature structural & molecular biology, Issue 11, Vol. 23, 1020-1028 DOI: 10.1038/nsmb.3305, PubMed: 27723736 |
Subramaniam S, Erler A, Fu J, Kranz A, Tang J, Gopalswamy M, Ramakrishnan S, Keller A, Grundmeier G, Müller D, Sattler M, Stewart AF (2016) DNA annealing by Redβ is insufficient for homologous recombination and the additional requirements involve intra- and inter-molecular interactions. Scientific reports, Vol. 6, 34525 DOI: 10.1038/srep34525, PubMed: 27708411 |
Delaforge E, Milles S, Huang JR, Bouvier D, Jensen MR, Sattler M, Hart DJ, Blackledge M (2016) Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions. Frontiers in molecular biosciences, Vol. 3, 54 DOI: 10.3389/fmolb.2016.00054, PubMed: 27679800 |
Dallmann A, Beribisky AV, Gnerlich F, Rübbelke M, Schiesser S, Carell T, Sattler M (2016) Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex. Chemistry (Weinheim an der Bergstrasse, Germany), Issue 43, Vol. 22, 15350-15359 DOI: 10.1002/chem.201602784, PubMed: 27608298 |
Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A, Gloeckner CJ (2016) Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts. Proceedings of the National Academy of Sciences of the United States of America, Issue 30, Vol. 113, E4357-66 DOI: 10.1073/pnas.1523708113, PubMed: 27357661 |
Zheng X, Ramani A, Soni K, Gottardo M, Zheng S, Ming Gooi L, Li W, Feng S, Mariappan A, Wason A, Widlund P, Pozniakovsky A, Poser I, Deng H, Ou G, Riparbelli M, Giuliano C, Hyman AA, Sattler M, Gopalakrishnan J, Li H (2016) Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length. Nature communications, Vol. 7, 11874 DOI: 10.1038/ncomms11874, PubMed: 27306797 |
Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M (2016) Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40. Nature communications, Vol. 7, 11032 DOI: 10.1038/ncomms11032, PubMed: 27010430 |
Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H (2016) Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation. Scientific reports, Vol. 6, 22540 DOI: 10.1038/srep22540, PubMed: 26931153 |
Jung B, Padula D, Burtscher I, Landerer C, Lutter D, Theis F, Messias AC, Geerlof A, Sattler M, Kremmer E, Boldt K, Ueffing M, Lickert H (2016) Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. PloS one, Issue 2, Vol. 11, e0149477 DOI: 10.1371/journal.pone.0149477, PubMed: 26901434 |
Schlundt A, Niessing D, Heissmeyer V, Sattler M (2016) RNA recognition by Roquin in posttranscriptional gene regulation. Wiley interdisciplinary reviews. RNA, Issue 4, Vol. 7, 455-69 DOI: 10.1002/wrna.1333, PubMed: 26844532 |
Carlon A, Ravera E, Hennig J, Parigi G, Sattler M, Luchinat C (2016) Improved Accuracy from Joint X-ray and NMR Refinement of a Protein-RNA Complex Structure. Journal of the American Chemical Society, Issue 5, Vol. 138, 1601-10 DOI: 10.1021/jacs.5b11598, PubMed: 26761154 |
Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang HS, Dalgliesh C, Meyer NH, Liu Y, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C (2016) Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68. Nature communications, Vol. 7, 10355 DOI: 10.1038/ncomms10355, PubMed: 26758068 |
Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D (2016) Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Scientific reports, Vol. 6, 18934 DOI: 10.1038/srep18934, PubMed: 26740240 |
Horn A, Hennig J, Ahmed YL, Stier G, Wild K, Sattler M, Sinning I (2015) Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction. Nature communications, Vol. 6, 8875 DOI: 10.1038/ncomms9875, PubMed: 26568381 |
Eckl JM, Scherr MJ, Freiburger L, Daake MA, Sattler M, Richter K (2015) Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites. The Journal of biological chemistry, Issue 52, Vol. 290, 30843-54 DOI: 10.1074/jbc.M115.693150, PubMed: 26511315 |
Emmanouilidis L, Gopalswamy M, Passon DM, Wilmanns M, Sattler M (2016) Structural biology of the import pathways of peroxisomal matrix proteins. Biochimica et biophysica acta, Issue 5, Vol. 1863, 804-13 DOI: 10.1016/j.bbamcr.2015.09.034, PubMed: 26450166 |
Giannopoulou EA, Emmanouilidis L, Sattler M, Dodt G, Wilmanns M (2016) Towards the molecular mechanism of the integration of peroxisomal membrane proteins. Biochimica et biophysica acta, Issue 5, Vol. 1863, 863-9 DOI: 10.1016/j.bbamcr.2015.09.031, PubMed: 26434995 |
Freiburger L, Sonntag M, Hennig J, Li J, Zou P, Sattler M (2015) Efficient segmental isotope labeling of multi-domain proteins using Sortase A. Journal of biomolecular NMR, Issue 1, Vol. 63, 1-8 DOI: 10.1007/s10858-015-9981-0, PubMed: 26319988 |
Xu T, Brandmaier S, Messias AC, Herder C, Draisma HH, Demirkan A, Yu Z, Ried JS, Haller T, Heier M, Campillos M, Fobo G, Stark R, Holzapfel C, Adam J, Chi S, Rotter M, Panni T, Quante AS, He Y, Prehn C, Roemisch-Margl W, Kastenmüller G, Willemsen G, Pool R, Kasa K, van Dijk KW, Hankemeier T, Meisinger C, Thorand B, Ruepp A, Hrabé de Angelis M, Li Y, Wichmann HE, Stratmann B, Strauch K, Metspalu A, Gieger C, Suhre K, Adamski J, Illig T, Rathmann W, Roden M, Peters A, van Duijn CM, Boomsma DI, Meitinger T, Wang-Sattler R (2015) Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes. Diabetes care, Issue 10, Vol. 38, 1858-67 DOI: 10.2337/dc15-0658, PubMed: 26251408 |
Haslbeck V, Drazic A, Eckl JM, Alte F, Helmuth M, Popowicz G, Schmidt W, Braun F, Weiwad M, Fischer G, Gemmecker G, Sattler M, Striggow F, Groll M, Richter K (2015) Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism. Bioscience reports, Issue 3, Vol. 35 DOI: 10.1042/BSR20150042, PubMed: 26182372 |
Meyer NH, Mayerhofer H, Tripsianes K, Blindow S, Barths D, Mewes A, Weimar T, Köhli T, Bade S, Madl T, Frey A, Haas H, Mueller-Dieckmann J, Sattler M, Schramm G (2015) A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation. The Journal of biological chemistry, Issue 36, Vol. 290, 22111-26 DOI: 10.1074/jbc.M115.675066, PubMed: 26163514 |
Hennig J, Warner LR, Simon B, Geerlof A, Mackereth CD, Sattler M (2015) Structural Analysis of Protein-RNA Complexes in Solution Using NMR Paramagnetic Relaxation Enhancements. Methods in enzymology, Vol. 558, 333-362 DOI: 10.1016/bs.mie.2015.02.006, PubMed: 26068746 |
Hennig J, Sattler M (2015) Deciphering the protein-RNA recognition code: combining large-scale quantitative methods with structural biology. BioEssays : news and reviews in molecular, cellular and developmental biology, Issue 8, Vol. 37, 899-908 DOI: 10.1002/bies.201500033, PubMed: 26059946 |
Friberg A, Thumann S, Hennig J, Zou P, Nössner E, Ling PD, Sattler M, Kempkes B (2015) The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation. PLoS pathogens, Issue 5, Vol. 11, e1004910 DOI: 10.1371/journal.ppat.1004910, PubMed: 26024477 |
Buchner S, Schlundt A, Lassak J, Sattler M, Jung K (2015) Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli. Journal of molecular biology, Issue 15, Vol. 427, 2548-2561 DOI: 10.1016/j.jmb.2015.05.001, PubMed: 25979249 |
Anosova I, Melnik S, Tripsianes K, Kateb F, Grummt I, Sattler M (2015) A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes. Nucleic acids research, Issue 10, Vol. 43, 5208-20 DOI: 10.1093/nar/gkv365, PubMed: 25916849 |
Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A (2015) Structural Characterization of LRRK2 Inhibitors. Journal of medicinal chemistry, Issue 9, Vol. 58, 3751-6 DOI: 10.1021/jm5018779, PubMed: 25897865 |
Sattler M (2015) Dynamic RNA world. RNA (New York, N.Y.), Issue 4, Vol. 21, 727-8 DOI: 10.1261/rna.050971.115, PubMed: 25780211 |
Riebold M, Kozany C, Freiburger L, Sattler M, Buchfelder M, Hausch F, Stalla GK, Paez-Pereda M (2015) A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease. Nature medicine, Issue 3, Vol. 21, 276-80 DOI: 10.1038/nm.3776, PubMed: 25665180 |
Dallmann A, Sattler M (2014) Detection of hydrogen bonds in dynamic regions of RNA by NMR spectroscopy. Current protocols in nucleic acid chemistry, Vol. 59, 7.22.1-19 DOI: 10.1002/0471142700.nc0722s59, PubMed: 25501594 |
Hennig J, Gebauer F, Sattler M (2014) Breaking the protein-RNA recognition code. Cell cycle (Georgetown, Tex.), Issue 23, Vol. 13, 3619-20 DOI: 10.4161/15384101.2014.986625, PubMed: 25486095 |
Holzmeister C, Gaupels F, Geerlof A, Sarioglu H, Sattler M, Durner J, Lindermayr C (2015) Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration. Journal of experimental botany, Issue 3, Vol. 66, 989-99 DOI: 10.1093/jxb/eru458, PubMed: 25428993 |
Zierer BK, Weiwad M, Rübbelke M, Freiburger L, Fischer G, Lorenz OR, Sattler M, Richter K, Buchner J (2014) Artificial accelerators of the molecular chaperone Hsp90 facilitate rate-limiting conformational transitions. Angewandte Chemie (International ed. in English), Issue 45, Vol. 53, 12257-62 DOI: 10.1002/anie.201406578, PubMed: 25244159 |
Hennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M (2014) Structural basis for the assembly of the Sxl-Unr translation regulatory complex. Nature, Issue 7526, Vol. 515, 287-90 DOI: 10.1038/nature13693, PubMed: 25209665 |
Tripsianes K, Friberg A, Barrandon C, Brooks M, van Tilbeurgh H, Seraphin B, Sattler M (2014) A novel protein-protein interaction in the RES (REtention and Splicing) complex. The Journal of biological chemistry, Issue 41, Vol. 289, 28640-50 DOI: 10.1074/jbc.M114.592311, PubMed: 25160624 |
Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, Sattler M (2014) Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation. Nature structural & molecular biology, Issue 8, Vol. 21, 671-8 DOI: 10.1038/nsmb.2855, PubMed: 25026077 |
Göbl C, Madl T, Simon B, Sattler M (2014) NMR approaches for structural analysis of multidomain proteins and complexes in solution. Progress in nuclear magnetic resonance spectroscopy, Vol. 80, 26-63 DOI: 10.1016/j.pnmrs.2014.05.003, PubMed: 24924266 |
Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J (2014) The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proceedings of the National Academy of Sciences of the United States of America, Issue 22, Vol. 111, 8155-60 DOI: 10.1073/pnas.1321502111, PubMed: 24830426 |
Huang JR, Warner LR, Sanchez C, Gabel F, Madl T, Mackereth CD, Sattler M, Blackledge M (2014) Transient electrostatic interactions dominate the conformational equilibrium sampled by multidomain splicing factor U2AF65: a combined NMR and SAXS study. Journal of the American Chemical Society, Issue 19, Vol. 136, 7068-76 DOI: 10.1021/ja502030n, PubMed: 24734879 |
Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmüller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, Gloeckner CJ (2014) Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain. Molecular and cellular biology, Issue 12, Vol. 34, 2147-61 DOI: 10.1128/MCB.00914-13, PubMed: 24687852 |
Hennig J, Sattler M (2014) The dynamic duo: combining NMR and small angle scattering in structural biology. Protein science : a publication of the Protein Society, Issue 6, Vol. 23, 669-82 DOI: 10.1002/pro.2467, PubMed: 24687405 |
Wang I, Hennig J, Jagtap PK, Sonntag M, Valcárcel J, Sattler M (2014) Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1. Nucleic acids research, Issue 9, Vol. 42, 5949-66 DOI: 10.1093/nar/gku193, PubMed: 24682828 |
Schilling F, Warner LR, Gershenzon NI, Skinner TE, Sattler M, Glaser SJ (2014) Next-generation heteronuclear decoupling for high-field biomolecular NMR spectroscopy. Angewandte Chemie (International ed. in English), Issue 17, Vol. 53, 4475-9 DOI: 10.1002/anie.201400178, PubMed: 24623579 |
Lorenz OR, Freiburger L, Rutz DA, Krause M, Zierer BK, Alvira S, Cuéllar J, Valpuesta JM, Madl T, Sattler M, Buchner J (2014) Modulation of the Hsp90 chaperone cycle by a stringent client protein. Molecular cell, Issue 6, Vol. 53, 941-53 DOI: 10.1016/j.molcel.2014.02.003, PubMed: 24613341 |
Tripsianes K, Chu NK, Friberg A, Sattler M, Becker CF (2014) Studying weak and dynamic interactions of posttranslationally modified proteins using expressed protein ligation. ACS chemical biology, Issue 2, Vol. 9, 347-52 DOI: 10.1021/cb400723j, PubMed: 24299430 |
Neuhaus A, Kooshapur H, Wolf J, Meyer NH, Madl T, Saidowsky J, Hambruch E, Lazam A, Jung M, Sattler M, Schliebs W, Erdmann R (2014) A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes. The Journal of biological chemistry, Issue 1, Vol. 289, 437-48 DOI: 10.1074/jbc.M113.499707, PubMed: 24235149 |
Kang C, Ye H, Chia J, Choi BH, Dhe-Paganon S, Simon B, Schütz U, Sattler M, Yoon HS (2013) Functional role of the flexible N-terminal extension of FKBP38 in catalysis. Scientific reports, Vol. 3, 2985 DOI: 10.1038/srep02985, PubMed: 24145868 |
Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G (2013) Structural features of Argonaute-GW182 protein interactions. Proceedings of the National Academy of Sciences of the United States of America, Issue 40, Vol. 110, E3770-9 DOI: 10.1073/pnas.1308510110, PubMed: 24043833 |
Zeitler B, Herrera Diaz A, Dangel A, Thellmann M, Meyer H, Sattler M, Lindermayr C (2013) De-novo design of antimicrobial peptides for plant protection. PloS one, Issue 8, Vol. 8, e71687 DOI: 10.1371/journal.pone.0071687, PubMed: 23951222 |
Dallmann A, Simon B, Duszczyk MM, Kooshapur H, Pardi A, Bermel W, Sattler M (2013) Efficient detection of hydrogen bonds in dynamic regions of RNA by sensitivity-optimized NMR pulse sequences. Angewandte Chemie (International ed. in English), Issue 40, Vol. 52, 10487-90 DOI: 10.1002/anie.201304391, PubMed: 23946052 |
Kadam RU, Garg D, Schwartz J, Visini R, Sattler M, Stocker A, Darbre T, Reymond JL (2013) CH-π "T-shape" interaction with histidine explains binding of aromatic galactosides to Pseudomonas aeruginosa lectin LecA. ACS chemical biology, Issue 9, Vol. 8, 1925-30 DOI: 10.1021/cb400303w, PubMed: 23869965 |
Müller R, Gräwert MA, Kern T, Madl T, Peschek J, Sattler M, Groll M, Buchner J (2013) High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation. Proceedings of the National Academy of Sciences of the United States of America, Issue 25, Vol. 110, 10183-8 DOI: 10.1073/pnas.1300547110, PubMed: 23733956 |
Gräber M, Hell M, Gröst C, Friberg A, Sperl B, Sattler M, Berg T (2013) Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells. Angewandte Chemie (International ed. in English), Issue 16, Vol. 52, 4487-91 DOI: 10.1002/anie.201208889, PubMed: 23512547 |
Hennig J, Wang I, Sonntag M, Gabel F, Sattler M (2013) Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex. Journal of biomolecular NMR, Issue 1, Vol. 56, 17-30 DOI: 10.1007/s10858-013-9719-9, PubMed: 23456097 |
Garg D, Beribisky AV, Ponterini G, Ligabue A, Marverti G, Martello A, Costi MP, Sattler M, Wade RC (2013) Translational repression of thymidylate synthase by targeting its mRNA. Nucleic acids research, Issue 7, Vol. 41, 4159-70 DOI: 10.1093/nar/gkt098, PubMed: 23423353 |
Kateb F, Perrin H, Tripsianes K, Zou P, Spadaccini R, Bottomley M, Franzmann TM, Buchner J, Ansieau S, Sattler M (2013) Structural and functional analysis of the DEAF-1 and BS69 MYND domains. PloS one, Issue 1, Vol. 8, e54715 DOI: 10.1371/journal.pone.0054715, PubMed: 23372760 |
Zeitler B, Bernhard A, Meyer H, Sattler M, Koop HU, Lindermayr C (2013) Production of a de-novo designed antimicrobial peptide in Nicotiana benthamiana. Plant molecular biology, Issue 3, Vol. 81, 259-72 DOI: 10.1007/s11103-012-9996-9, PubMed: 23242916 |
Zhang Y, Madl T, Bagdiul I, Kern T, Kang HS, Zou P, Mäusbacher N, Sieber SA, Krämer A, Sattler M (2013) Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. Nucleic acids research, Issue 2, Vol. 41, 1343-54 DOI: 10.1093/nar/gks1097, PubMed: 23175611 |
Wang-Sattler R, Yu Z, Herder C, Messias AC, Floegel A, He Y, Heim K, Campillos M, Holzapfel C, Thorand B, Grallert H, Xu T, Bader E, Huth C, Mittelstrass K, Döring A, Meisinger C, Gieger C, Prehn C, Roemisch-Margl W, Carstensen M, Xie L, Yamanaka-Okumura H, Xing G, Ceglarek U, Thiery J, Giani G, Lickert H, Lin X, Li Y, Boeing H, Joost HG, de Angelis MH, Rathmann W, Suhre K, Prokisch H, Peters A, Meitinger T, Roden M, Wichmann HE, Pischon T, Adamski J, Illig T (2012) Novel biomarkers for pre-diabetes identified by metabolomics. Molecular systems biology, Vol. 8, 615 DOI: 10.1038/msb.2012.43, PubMed: 23010998 |
Mathioudakis N, Palencia A, Kadlec J, Round A, Tripsianes K, Sattler M, Pillai RS, Cusack S (2012) The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors. RNA (New York, N.Y.), Issue 11, Vol. 18, 2056-72 DOI: 10.1261/rna.034181.112, PubMed: 22996915 |
Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S (2012) In support of the BMRB. Nature structural & molecular biology, Issue 9, Vol. 19, 854-60 DOI: 10.1038/nsmb.2371, PubMed: 22955930 |
Mackereth CD, Sattler M (2012) Dynamics in multi-domain protein recognition of RNA. Current opinion in structural biology, Issue 3, Vol. 22, 287-96 DOI: 10.1016/j.sbi.2012.03.013, PubMed: 22516180 |
Tavanez JP, Madl T, Kooshapur H, Sattler M, Valcárcel J (2012) hnRNP A1 proofreads 3' splice site recognition by U2AF. Molecular cell, Issue 3, Vol. 45, 314-29 DOI: 10.1016/j.molcel.2011.11.033, PubMed: 22325350 |
Holdermann I, Meyer NH, Round A, Wild K, Sattler M, Sinning I (2012) Chromodomains read the arginine code of post-translational targeting. Nature structural & molecular biology, Issue 2, Vol. 19, 260-3 DOI: 10.1038/nsmb.2196, PubMed: 22231402 |
Tripsianes K, Madl T, Machyna M, Fessas D, Englbrecht C, Fischer U, Neugebauer KM, Sattler M (2011) Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins. Nature structural & molecular biology, Issue 12, Vol. 18, 1414-20 DOI: 10.1038/nsmb.2185, PubMed: 22101937 |
Liokatis S, Edlich C, Soupsana K, Giannios I, Panagiotidou P, Tripsianes K, Sattler M, Georgatos SD, Politou AS (2012) Solution structure and molecular interactions of lamin B receptor Tudor domain. The Journal of biological chemistry, Issue 2, Vol. 287, 1032-42 DOI: 10.1074/jbc.M111.281303, PubMed: 22052904 |
Duszczyk MM, Wutz A, Rybin V, Sattler M (2011) The Xist RNA A-repeat comprises a novel AUCG tetraloop fold and a platform for multimerization. RNA (New York, N.Y.), Issue 11, Vol. 17, 1973-82 DOI: 10.1261/rna.2747411, PubMed: 21947263 |
Kadam RU, Bergmann M, Hurley M, Garg D, Cacciarini M, Swiderska MA, Nativi C, Sattler M, Smyth AR, Williams P, Cámara M, Stocker A, Darbre T, Reymond JL (2011) A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of Pseudomonas aeruginosa biofilms. Angewandte Chemie (International ed. in English), Issue 45, Vol. 50, 10631-5 DOI: 10.1002/anie.201104342, PubMed: 21919164 |
Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR (2011) Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circulation research, Issue 7, Vol. 109, 758-69 DOI: 10.1161/CIRCRESAHA.111.245787, PubMed: 21799151 |
Duszczyk MM, Sattler M (2012) ¹H, ¹³C, ¹⁵N and ³¹P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation. Biomolecular NMR assignments, Issue 1, Vol. 6, 75-7 DOI: 10.1007/s12104-011-9328-z, PubMed: 21779925 |
Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcárcel J, Sattler M (2011) Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF. Nature, Issue 7356, Vol. 475, 408-11 DOI: 10.1038/nature10171, PubMed: 21753750 |
Meyer NH, Schramm G, Sattler M (2011) 1H, 13C and 15N chemical shift assignments of IPSEΔNLS. Biomolecular NMR assignments, Issue 2, Vol. 5, 225-7 DOI: 10.1007/s12104-011-9305-6, PubMed: 21516468 |
Madl T, Güttler T, Görlich D, Sattler M (2011) Structural analysis of large protein complexes using solvent paramagnetic relaxation enhancements. Angewandte Chemie (International ed. in English), Issue 17, Vol. 50, 3993-7 DOI: 10.1002/anie.201007168, PubMed: 21442693 |
Vojnic E, Mourão A, Seizl M, Simon B, Wenzeck L, Larivière L, Baumli S, Baumgart K, Meisterernst M, Sattler M, Cramer P (2011) Structure and VP16 binding of the Mediator Med25 activator interaction domain. Nature structural & molecular biology, Issue 4, Vol. 18, 404-9 DOI: 10.1038/nsmb.1997, PubMed: 21378965 |
Madl T, Gabel F, Sattler M (2011) NMR and small-angle scattering-based structural analysis of protein complexes in solution. Journal of structural biology, Issue 3, Vol. 173, 472-82 DOI: 10.1016/j.jsb.2010.11.004, PubMed: 21074620 |
Güttler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, Ficner R, Sattler M, Görlich D (2010) NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nature structural & molecular biology, Issue 11, Vol. 17, 1367-76 DOI: 10.1038/nsmb.1931, PubMed: 20972448 |
Tripsianes K, Sattler M (2010) Repeat recognition. Structure (London, England : 1993), Issue 10, Vol. 18, 1228-9 DOI: 10.1016/j.str.2010.09.006, PubMed: 20947010 |
Bhushan S, Meyer H, Starosta AL, Becker T, Mielke T, Berninghausen O, Sattler M, Wilson DN, Beckmann R (2010) Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide. Molecular cell, Issue 1, Vol. 40, 138-46 DOI: 10.1016/j.molcel.2010.09.009, PubMed: 20932481 |
Friberg A, Oddone A, Klymenko T, Müller J, Sattler M (2010) Structure of an atypical Tudor domain in the Drosophila Polycomblike protein. Protein science : a publication of the Protein Society, Issue 10, Vol. 19, 1906-16 DOI: 10.1002/pro.476, PubMed: 20669242 |
Meyer NH, Tripsianes K, Vincendeau M, Madl T, Kateb F, Brack-Werner R, Sattler M (2010) Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain. The Journal of biological chemistry, Issue 37, Vol. 285, 28893-901 DOI: 10.1074/jbc.M110.126185, PubMed: 20610388 |
Madl T, Felli IC, Bertini I, Sattler M (2010) Structural analysis of protein interfaces from 13C direct-detected paramagnetic relaxation enhancements. Journal of the American Chemical Society, Issue 21, Vol. 132, 7285-7 DOI: 10.1021/ja1014508, PubMed: 20462243 |
Mourão A, Varrot A, Mackereth CD, Cusack S, Sattler M (2010) Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX. RNA (New York, N.Y.), Issue 6, Vol. 16, 1205-16 DOI: 10.1261/rna.2009910, PubMed: 20430857 |
Simon B, Madl T, Mackereth CD, Nilges M, Sattler M (2010) An efficient protocol for NMR-spectroscopy-based structure determination of protein complexes in solution. Angewandte Chemie (International ed. in English), Issue 11, Vol. 49, 1967-70 DOI: 10.1002/anie.200906147, PubMed: 20148424 |
Rumpf J, Simon B, Groemping Y, Sattler M (2008) 1H, 13C, and 15N chemical shift assignments for the Eps15-EH2-stonin 2 complex. Biomolecular NMR assignments, Issue 1, Vol. 2, 55-8 DOI: 10.1007/s12104-008-9083-y, PubMed: 19636924 |
Corsini L, Sattler M (2008) Backbone assignment of the UHM domain of Puf60 free and bound to five ligands. Biomolecular NMR assignments, Issue 2, Vol. 2, 211-4 DOI: 10.1007/s12104-008-9123-7, PubMed: 19636907 |
Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S (2009) Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. The EMBO journal, Issue 15, Vol. 28, 2293-306 DOI: 10.1038/emboj.2009.175, PubMed: 19556969 |
Madl T, Sattler M (2009) Adhesion dance with raver. Structure (London, England : 1993), Issue 6, Vol. 17, 781-3 DOI: 10.1016/j.str.2009.05.004, PubMed: 19523894 |
Friberg A, Corsini L, Mourão A, Sattler M (2009) Structure and ligand binding of the extended Tudor domain of D. melanogaster Tudor-SN. Journal of molecular biology, Issue 4, Vol. 387, 921-34 DOI: 10.1016/j.jmb.2009.02.018, PubMed: 19232356 |
Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M (2009) Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. The EMBO journal, Issue 6, Vol. 28, 745-54 DOI: 10.1038/emboj.2009.7, PubMed: 19197237 |
Duszczyk MM, Zanier K, Sattler M (2008) A NMR strategy to unambiguously distinguish nucleic acid hairpin and duplex conformations applied to a Xist RNA A-repeat. Nucleic acids research, Issue 22, Vol. 36, 7068-77 DOI: 10.1093/nar/gkn776, PubMed: 18987004 |
Bogomolovas J, Simon B, Sattler M, Stier G (2009) Screening of fusion partners for high yield expression and purification of bioactive viscotoxins. Protein expression and purification, Issue 1, Vol. 64, 16-23 DOI: 10.1016/j.pep.2008.10.003, PubMed: 18983922 |
Corsini L, Hothorn M, Stier G, Rybin V, Scheffzek K, Gibson TJ, Sattler M (2009) Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60. The Journal of biological chemistry, Issue 1, Vol. 284, 630-639 DOI: 10.1074/jbc.M805395200, PubMed: 18974054 |
Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K (2008) Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2. EMBO reports, Issue 11, Vol. 9, 1134-40 DOI: 10.1038/embor.2008.188, PubMed: 18833287 |
Corsini L, Hothorn M, Scheffzek K, Sattler M, Stier G (2008) Thioredoxin as a fusion tag for carrier-driven crystallization. Protein science : a publication of the Protein Society, Issue 12, Vol. 17, 2070-9 DOI: 10.1110/ps.037564.108, PubMed: 18780816 |
Spadaccini R, Perrin H, Bottomley MJ, Ansieau S, Sattler M (2008) Retraction notice to "Structure and functional analysis of the MYND domain" [J. Mol. Biol. (2006) 358, 498-508]. Journal of molecular biology, Issue 5, Vol. 376, 1523 DOI: 10.1016/j.jmb.2008.01.071, PubMed: 18286714 |
Rumpf J, Simon B, Jung N, Maritzen T, Haucke V, Sattler M, Groemping Y (2008) Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. The EMBO journal, Issue 3, Vol. 27, 558-69 DOI: 10.1038/sj.emboj.7601980, PubMed: 18200045 |
Black SL, Stanley WA, Filipp FV, Bhairo M, Verma A, Wichmann O, Sattler M, Wilmanns M, Schultz C (2008) Probing lipid- and drug-binding domains with fluorescent dyes. Bioorganic & medicinal chemistry, Issue 3, Vol. 16, 1162-73 DOI: 10.1016/j.bmc.2007.10.080, PubMed: 18024138 |
Corsini L, Bonnal S, Basquin J, Hothorn M, Scheffzek K, Valcárcel J, Sattler M (2007) U2AF-homology motif interactions are required for alternative splicing regulation by SPF45. Nature structural & molecular biology, Issue 7, Vol. 14, 620-9 DOI: 10.1038/nsmb1260, PubMed: 17589525 |
Filipp FV, Sattler M (2007) Conformational plasticity of the lipid transfer protein SCP2. Biochemistry, Issue 27, Vol. 46, 7980-91 DOI: 10.1021/bi6025616, PubMed: 17566986 |
Brumbaugh J, Schleifenbaum A, Stier G, Sattler M, Schultz C (2006) Single- and dual-parameter FRET kinase probes based on pleckstrin. Nature protocols, Issue 2, Vol. 1, 1044-55 DOI: 10.1038/nprot.2006.177, PubMed: 17406341 |
Corsini L, Sattler M (2007) Tudor hooks up with DNA repair. Nature structural & molecular biology, Issue 2, Vol. 14, 98-9 DOI: 10.1038/nsmb0207-98, PubMed: 17277801 |
Oddone A, Lorentzen E, Basquin J, Gasch A, Rybin V, Conti E, Sattler M (2007) Structural and biochemical characterization of the yeast exosome component Rrp40. EMBO reports, Issue 1, Vol. 8, 63-9 DOI: 10.1038/sj.embor.7400856, PubMed: 17159918 |
Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M (2006) Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p. Molecular cell, Issue 5, Vol. 24, 653-663 DOI: 10.1016/j.molcel.2006.10.024, PubMed: 17157249 |
Messias AC, Harnisch C, Ostareck-Lederer A, Sattler M, Ostareck DH (2006) The DICE-binding activity of KH domain 3 of hnRNP K is affected by c-Src-mediated tyrosine phosphorylation. Journal of molecular biology, Issue 3, Vol. 361, 470-81 DOI: 10.1016/j.jmb.2006.06.025, PubMed: 16854432 |
Soares LM, Zanier K, Mackereth C, Sattler M, Valcárcel J (2006) Intron removal requires proofreading of U2AF/3' splice site recognition by DEK. Science (New York, N.Y.), Issue 5782, Vol. 312, 1961-5 DOI: 10.1126/science.1128659, PubMed: 16809543 |
Lescrinier E, Nauwelaerts K, Zanier K, Poesen K, Sattler M, Herdewijn P (2006) The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes formation of a unique U-turn motif. Nucleic acids research, Issue 10, Vol. 34, 2878-86 DOI: 10.1093/nar/gkl081, PubMed: 16738127 |
Kang CB, Ye H, Vivekanandan S, Simon B, Sattler M, Yoon HS (2006) Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD). Journal of biomolecular NMR, Vol. 36 Suppl 1, 37 DOI: 10.1007/s10858-006-9001-5, PubMed: 16718587 |
Edlich C, Simon B, Sattler M, Muhle-Goll C (2006) New NMR assignment 1H, 13C, and 15N assignment of the second PH domain of human pleckstrin (234-350). Journal of biomolecular NMR, Vol. 36 Suppl 1, 21 DOI: 10.1007/s10858-005-6053-x, PubMed: 16642402 |
Pimienta G, Gabel F, Zanier K, Conti E, Sattler M (2006) Chemical shift backbone assignments of TAP-N, the 31 kDa cargo-binding region of the protein TAP. Journal of biomolecular NMR, Vol. 36 Suppl 1, 23 DOI: 10.1007/s10858-006-0002-1, PubMed: 16596343 |
Spadaccini R, Perrin H, Bottomley MJ, Ansieau S, Sattler M (2006) Structure and functional analysis of the MYND domain. Journal of molecular biology, Issue 2, Vol. 358, 498-508 DOI: 10.1016/j.jmb.2006.01.087, PubMed: 16527309 |
Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M, Musacchio A (2006) Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. The EMBO journal, Issue 6, Vol. 25, 1273-84 DOI: 10.1038/sj.emboj.7601033, PubMed: 16525508 |
Spadaccini R, Reidt U, Dybkov O, Will C, Frank R, Stier G, Corsini L, Wahl MC, Lührmann R, Sattler M (2006) Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing. RNA (New York, N.Y.), Issue 3, Vol. 12, 410-25 DOI: 10.1261/rna.2271406, PubMed: 16495236 |
Gabel F, Simon B, Sattler M (2006) A target function for quaternary structural refinement from small angle scattering and NMR orientational restraints. European biophysics journal : EBJ, Issue 4, Vol. 35, 313-27 DOI: 10.1007/s00249-005-0037-3, PubMed: 16416140 |
Brumbaugh J, Schleifenbaum A, Gasch A, Sattler M, Schultz C (2006) A dual parameter FRET probe for measuring PKC and PKA activity in living cells. Journal of the American Chemical Society, Issue 1, Vol. 128, 24-5 DOI: 10.1021/ja0562200, PubMed: 16390103 |
Vojnic E, Simon B, Strahl BD, Sattler M, Cramer P (2006) Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription. The Journal of biological chemistry, Issue 1, Vol. 281, 13-5 DOI: 10.1074/jbc.C500423200, PubMed: 16286474 |
Lingel A, Simon B, Izaurralde E, Sattler M (2005) The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO reports, Issue 12, Vol. 6, 1149-55 DOI: 10.1038/sj.embor.7400583, PubMed: 16270100 |
Wiesner S, Hantschel O, Mackereth CD, Superti-Furga G, Sattler M (2005) NMR Assignment Reveals an alpha-Helical Fold for the F-Actin Binding Domain of Human Bcr-Abl/c-Abl. Journal of biomolecular NMR, Issue 4, Vol. 32, 335 DOI: 10.1007/s10858-005-8868-x, PubMed: 16211486 |
Hantschel O, Wiesner S, Güttler T, Mackereth CD, Rix LL, Mikes Z, Dehne J, Görlich D, Sattler M, Superti-Furga G (2005) Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl. Molecular cell, Issue 4, Vol. 19, 461-73 DOI: 10.1016/j.molcel.2005.06.030, PubMed: 16109371 |
Mackereth CD, Simon B, Sattler M (2005) Extending the size of protein-RNA complexes studied by nuclear magnetic resonance spectroscopy. Chembiochem : a European journal of chemical biology, Issue 9, Vol. 6, 1578-84 DOI: 10.1002/cbic.200500106, PubMed: 16075426 |
Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S (2005) X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids. Structure (London, England : 1993), Issue 7, Vol. 13, 1055-67 DOI: 10.1016/j.str.2005.04.008, PubMed: 16004877 |
Markwick PR, Sprangers R, Sattler M (2005) Local structure and anisotropic backbone dynamics from cross-correlated NMR relaxation in proteins. Angewandte Chemie (International ed. in English), Issue 21, Vol. 44, 3232-7 DOI: 10.1002/anie.200462495, PubMed: 15844105 |
Lingel A, Sattler M (2005) Novel modes of protein-RNA recognition in the RNAi pathway. Current opinion in structural biology, Issue 1, Vol. 15, 107-15 DOI: 10.1016/j.sbi.2005.01.010, PubMed: 15718141 |
Edlich C, Stier G, Simon B, Sattler M, Muhle-Goll C (2005) Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin. Structure (London, England : 1993), Issue 2, Vol. 13, 277-86 DOI: 10.1016/j.str.2004.11.012, PubMed: 15698571 |
Bottomley MJ, Stier G, Pennacchini D, Legube G, Simon B, Akhtar A, Sattler M, Musco G (2005) NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease. The Journal of biological chemistry, Issue 12, Vol. 280, 11505-12 DOI: 10.1074/jbc.M413959200, PubMed: 15649886 |
Sattler MA, Mtasiwa D, Kiama M, Premji Z, Tanner M, Killeen GF, Lengeler C (2005) Habitat characterization and spatial distribution of Anopheles sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period. Malaria journal, Vol. 4, 4 DOI: 10.1186/1475-2875-4-4, PubMed: 15649333 |
Civera C, Simon B, Stier G, Sattler M, Macias MJ (2005) Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily. Proteins, Issue 2, Vol. 58, 354-66 DOI: 10.1002/prot.20320, PubMed: 15573383 |
Schleifenbaum A, Stier G, Gasch A, Sattler M, Schultz C (2004) Genetically encoded FRET probe for PKC activity based on pleckstrin. Journal of the American Chemical Society, Issue 38, Vol. 126, 11786-7 DOI: 10.1021/ja0460155, PubMed: 15382901 |
Markwick PR, Sattler M (2004) Site-specific variations of carbonyl chemical shift anisotropies in proteins. Journal of the American Chemical Society, Issue 37, Vol. 126, 11424-5 DOI: 10.1021/ja047859r, PubMed: 15366873 |
Peng C, Unger SW, Filipp FV, Sattler M, Szalma S (2004) Automated evaluation of chemical shift perturbation spectra: New approaches to quantitative analysis of receptor-ligand interaction NMR spectra. Journal of biomolecular NMR, Issue 4, Vol. 29, 491-504 DOI: 10.1023/B:JNMR.0000034351.37982.9e, PubMed: 15243180 |
Lingel A, Simon B, Izaurralde E, Sattler M (2004) NMR assignment of the Drosophila Argonaute2 PAZ domain. Journal of biomolecular NMR, Issue 3, Vol. 29, 421-2 DOI: 10.1023/B:JNMR.0000032513.15693.04, PubMed: 15213449 |
Lingel A, Simon B, Izaurralde E, Sattler M (2004) Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nature structural & molecular biology, Issue 6, Vol. 11, 576-7 DOI: 10.1038/nsmb777, PubMed: 15156196 |
Messias AC, Sattler M (2004) Structural basis of single-stranded RNA recognition. Accounts of chemical research, Issue 5, Vol. 37, 279-87 DOI: 10.1021/ar030034m, PubMed: 15147168 |
Simon B, Sattler M (2004) Speeding up biomolecular NMR spectroscopy. Angewandte Chemie (International ed. in English), Issue 7, Vol. 43, 782-6 DOI: 10.1002/anie.200301680, PubMed: 14767949 |
Amininasab M, Elmi MM, Endlich N, Endlich K, Parekh N, Naderi-Manesh H, Schaller J, Mostafavi H, Sattler M, Sarbolouki MN, Muhle-Goll C (2004) Functional and structural characterization of a novel member of the natriuretic family of peptides from the venom of Pseudocerastes persicus. FEBS letters, Issue 1-3, Vol. 557, 104-8 DOI: 10.1016/s0014-5793(03)01455-8, PubMed: 14741349 |
Lingel A, Simon B, Izaurralde E, Sattler M (2003) Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature, Issue 6965, Vol. 426, 465-9 DOI: 10.1038/nature02123, PubMed: 14615801 |
Selenko P, Gregorovic G, Sprangers R, Stier G, Rhani Z, Krämer A, Sattler M (2003) Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP. Molecular cell, Issue 4, Vol. 11, 965-76 DOI: 10.1016/s1097-2765(03)00115-1, PubMed: 12718882 |
Surdo PL, Bottomley MJ, Sattler M, Scheffzek K (2003) Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions. Molecular endocrinology (Baltimore, Md.), Issue 7, Vol. 17, 1283-95 DOI: 10.1210/me.2002-0409, PubMed: 12702733 |
Bottomley MJ, Sattler M (2003) 1H, 13C and 15N backbone resonance assignments of the SAND domains from glucocorticoid modulatory element binding proteins-1 and -2. Journal of biomolecular NMR, Issue 3, Vol. 25, 259-60 DOI: 10.1023/a:1022817817312, PubMed: 12652142 |
Sprangers R, Groves MR, Sinning I, Sattler M (2003) High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues. Journal of molecular biology, Issue 2, Vol. 327, 507-20 DOI: 10.1016/s0022-2836(03)00148-7, PubMed: 12628254 |
Selenko P, Sattler M (2003) Switching off the switch. Structure (London, England : 1993), Issue 2, Vol. 11, 131-2 DOI: 10.1016/s0969-2126(03)00012-1, PubMed: 12575930 |
Sprangers R, Selenko P, Sattler M, Sinning I, Groves MR (2003) Definition of domain boundaries and crystallization of the SMN Tudor domain. Acta crystallographica. Section D, Biological crystallography, Issue Pt 2, Vol. 59, 366-8 DOI: 10.1107/s0907444902021406, PubMed: 12554955 |
Markwick PR, Sprangers R, Sattler M (2003) Dynamic effects on j-couplings across hydrogen bonds in proteins. Journal of the American Chemical Society, Issue 3, Vol. 125, 644-5 DOI: 10.1021/ja028875w, PubMed: 12526659 |
Simon B, Sattler M (2002) De novo structure determination from residual dipolar couplings by NMR spectroscopy. Angewandte Chemie (International ed. in English), Issue 3, Vol. 41, 437-40 DOI: 10.1002/1521-3773(20020201)41:3<437::aid-anie437>3.0.co;2-3, PubMed: 12491371 |
Wiesner S, Stier G, Sattler M, Macias MJ (2002) Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40. Journal of molecular biology, Issue 4, Vol. 324, 807-22 DOI: 10.1016/s0022-2836(02)01145-2, PubMed: 12460579 |
Douangamath A, Filipp FV, Klein AT, Barnett P, Zou P, Voorn-Brouwer T, Vega MC, Mayans OM, Sattler M, Distel B, Wilmanns M (2002) Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain. Molecular cell, Issue 5, Vol. 10, 1007-17 DOI: 10.1016/s1097-2765(02)00749-9, PubMed: 12453410 |
Kellenberger E, Stier G, Sattler M (2002) Induced folding of the U2AF35 RRM upon binding to U2AF65. FEBS letters, Issue 1-3, Vol. 528, 171-6 DOI: 10.1016/s0014-5793(02)03294-5, PubMed: 12297299 |
Zanier K, Luyten I, Crombie C, Muller B, Schümperli D, Linge JP, Nilges M, Sattler M (2002) Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression. RNA (New York, N.Y.), Issue 1, Vol. 8, 29-46 DOI: 10.1017/s1355838202014061, PubMed: 11871659 |