Banasik M, Napolitano V, Blat A, Abdulkarim K, Plewka J, Czaplewski C, Gieldon A, Kozak M, Wladyka B, Popowicz G, Dubin G (2024) Structural dynamics of the TPR domain of the peroxisomal cargo receptor Pex5 in Trypanosoma. International journal of biological macromolecules, 135510 DOI: 10.1016/j.ijbiomac.2024.135510, PubMed: 39304044 |
Lis K, Plewka J, Menezes F, Bielecka E, Chykunova Y, Pustelny K, Niebling S, Garcia AS, Garcia-Alai M, Popowicz GM, Nowak JS, Czarna A, Kantyka T, Pyrc K (2024) Corrigendum to "SARS-CoV-2 Mpro oligomerization as a potential target for therapy" [Int. J. Biol. Macromol. 267 (Part 1) (May 2024) 131392]. International journal of biological macromolecules, Issue Pt 1, Vol. 276, 133473 DOI: 10.1016/j.ijbiomac.2024.133473, PubMed: 39024924 |
Siebenmorgen T, Menezes F, Benassou S, Merdivan E, Didi K, Mourão ASD, Kitel R, Liò P, Kesselheim S, Piraud M, Theis FJ, Sattler M, Popowicz GM (2024) MISATO: machine learning dataset of protein-ligand complexes for structure-based drug discovery. Nature computational science, Issue 5, Vol. 4, 367-378 DOI: 10.1038/s43588-024-00627-2, PubMed: 38730184 |
Gaussmann S, Peschel R, Ott J, Zak KM, Sastre J, Delhommel F, Popowicz GM, Boekhoven J, Schliebs W, Erdmann R, Sattler M (2024) Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif. Nature communications, Issue 1, Vol. 15, 3317 DOI: 10.1038/s41467-024-47605-w, PubMed: 38632234 |
Lis K, Plewka J, Menezes F, Bielecka E, Chykunova Y, Pustelny K, Niebling S, Garcia AS, Garcia-Alai M, Popowicz GM, Czarna A, Kantyka T, Pyrc K (2024) SARS-CoV-2 Mpro oligomerization as a potential target for therapy. International journal of biological macromolecules, Issue Pt 1, Vol. 267, 131392 DOI: 10.1016/j.ijbiomac.2024.131392, PubMed: 38582483 |
Matsuda A, Plewka J, Rawski M, Mourão A, Zajko W, Siebenmorgen T, Kresik L, Lis K, Jones AN, Pachota M, Karim A, Hartman K, Nirwal S, Sonani R, Chykunova Y, Minia I, Mak P, Landthaler M, Nowotny M, Dubin G, Sattler M, Suder P, Popowicz GM, Pyrć K, Czarna A (2024) Despite the odds: formation of the SARS-CoV-2 methylation complex. Nucleic acids research, Issue 11, Vol. 52, 6441-6458 DOI: 10.1093/nar/gkae165, PubMed: 38499483 |
Giehler F, Ostertag MS, Sommermann T, Weidl D, Sterz KR, Kutz H, Moosmann A, Feller SM, Geerlof A, Biesinger B, Popowicz GM, Kirchmair J, Kieser A (2024) Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex. Nature communications, Issue 1, Vol. 15, 414 DOI: 10.1038/s41467-023-44455-w, PubMed: 38195569 |
Kitel R, Surmiak E, Borggräfe J, Kalinowska-Tluscik J, Golik P, Czub M, Uzar W, Musielak B, Madej M, Popowicz GM, Dubin G, Holak TA (2023) Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction. Journal of medicinal chemistry, Issue 23, Vol. 66, 15715-15727 DOI: 10.1021/acs.jmedchem.3c00877, PubMed: 38039505 |
Pustelny K, Grygier P, Barzowska A, Pucelik B, Matsuda A, Mrowiec K, Slugocka E, Popowicz GM, Dubin G, Czarna A (2023) Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics. Scientific reports, Issue 1, Vol. 13, 18114 DOI: 10.1038/s41598-023-44810-3, PubMed: 37872245 |
Menezes F, Popowicz GM (2023) When catchers meet - a computational study on the dimerization of the Buckycatcher. Physical chemistry chemical physics : PCCP, Issue 35, Vol. 25, 24031-24041 DOI: 10.1039/d3cp02903d, PubMed: 37646477 |
Troisi R, Napolitano V, Rossitto E, Osman W, Nagano M, Wakui K, Popowicz GM, Yoshimoto K, Sica F (2023) Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide. Nucleic acids research, Issue 16, Vol. 51, 8880-8890 DOI: 10.1093/nar/gkad634, PubMed: 37503836 |
Marciniak M, Mróz P, Napolitano V, Kalel VC, Fino R, Pykacz E, Schliebs W, Plettenburg O, Erdmann R, Sattler M, Popowicz GM, Dawidowski M (2023) Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template. European journal of medicinal chemistry, Vol. 258, 115587 DOI: 10.1016/j.ejmech.2023.115587, PubMed: 37406382 |
Svilenov HL, Delhommel F, Siebenmorgen T, Rührnößl F, Popowicz GM, Reiter A, Sattler M, Brockmeyer C, Buchner J (2023) Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2. Communications biology, Issue 1, Vol. 6, 386 DOI: 10.1038/s42003-023-04762-w, PubMed: 37031320 |
Menezes F, Popowicz GM (2023) A Buckycatcher in Solution-A Computational Perspective. Molecules (Basel, Switzerland), Issue 6, Vol. 28 DOI: 10.3390/molecules28062841, PubMed: 36985812 |
Grygier P, Pustelny K, Nowak J, Golik P, Popowicz GM, Plettenburg O, Dubin G, Menezes F, Czarna A (2023) Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective. Journal of medicinal chemistry, Issue 6, Vol. 66, 4009-4024 DOI: 10.1021/acs.jmedchem.2c01887, PubMed: 36883902 |
Narayanan D, Tran KT, Pallesen JS, Solbak SMØ, Qin Y, Mukminova E, Luchini M, Vasilyeva KO, González Chichón D, Goutsiou G, Poulsen C, Haapanen N, Popowicz GM, Sattler M, Olagnier D, Gajhede M, Bach A (2022) Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. Journal of medicinal chemistry, Issue 21, Vol. 65, 14481-14526 DOI: 10.1021/acs.jmedchem.2c00830, PubMed: 36263945 |
Napolitano V, Mróz P, Marciniak M, Kalel VC, Softley CA, Janna Olmos JD, Tippler BG, Schorpp K, Rioton S, Fröhlich T, Plettenburg O, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dawidowski M, Dubin G (2022) Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma. European journal of medicinal chemistry, Vol. 243, 114778 DOI: 10.1016/j.ejmech.2022.114778, PubMed: 36194937 |
Kitel R, Rodríguez I, Del Corte X, Atmaj J, Żarnik M, Surmiak E, Muszak D, Magiera-Mularz K, Popowicz GM, Holak TA, Musielak B (2022) Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments. ACS chemical biology, Issue 9, Vol. 17, 2655-2663 DOI: 10.1021/acschembio.2c00583, PubMed: 36073782 |
Napolitano V, Softley CA, Blat A, Kalel VC, Schorpp K, Siebenmorgen T, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dubin G (2022) Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma. Scientific reports, Issue 1, Vol. 12, 14705 DOI: 10.1038/s41598-022-18841-1, PubMed: 36038611 |
Menezes F, Popowicz GM (2022) ULYSSES: An Efficient and Easy to Use Semiempirical Library for C+. Journal of chemical information and modeling, Issue 16, Vol. 62, 3685-3694 DOI: 10.1021/acs.jcim.2c00757, PubMed: 35930308 |
Menezes F, Popowicz GM (2022) Acid Rain and Flue Gas: Quantum Chemical Hydrolysis of NO2. Chemphyschem : a European journal of chemical physics and physical chemistry, Issue 21, Vol. 23, e202200395 DOI: 10.1002/cphc.202200395, PubMed: 35875889 |
Menezes F, Popowicz GM (2022) How to Catch the Ball: Fullerene Binding to the Corannulene Pincer. Molecules (Basel, Switzerland), Issue 12, Vol. 27 DOI: 10.3390/molecules27123838, PubMed: 35744963 |
Jones AN, Mourão A, Czarna A, Matsuda A, Fino R, Pyrc K, Sattler M, Popowicz GM (2022) Characterization of SARS-CoV-2 replication complex elongation and proofreading activity. Scientific reports, Issue 1, Vol. 12, 9593 DOI: 10.1038/s41598-022-13380-1, PubMed: 35688849 |
Czarna A, Plewka J, Kresik L, Matsuda A, Karim A, Robinson C, O'Byrne S, Cunningham F, Georgiou I, Wilk P, Pachota M, Popowicz G, Wyatt PG, Dubin G, Pyrć K (2022) Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity. Structure (London, England : 1993), Issue 8, Vol. 30, 1050-1054.e2 DOI: 10.1016/j.str.2022.04.014, PubMed: 35609600 |
Popowicz GM, Pyrc K, Hadian K (2022) Vaccination versus SARS-CoV-2 Omicron: three vaccine doses win the battle. Signal transduction and targeted therapy, Issue 1, Vol. 7, 140 DOI: 10.1038/s41392-022-01000-3, PubMed: 35477929 |
Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, Kampmann M, Lamb DC, Rosenzweig R, Sattler M, Buchner J (2022) NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Molecular cell, Issue 3, Vol. 82, 555-569.e7 DOI: 10.1016/j.molcel.2021.12.031, PubMed: 35063133 |
Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hölscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Slysz K, Szczepanski A, Greve-Isdahl Mohn K, Blomberg B, Sattler M, Hadian K, Popowicz GM, Pyrc K (2022) Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell chemical biology, Issue 5, Vol. 29, 774-784.e8 DOI: 10.1016/j.chembiol.2021.11.006, PubMed: 35021060 |
Li M, Gaussmann S, Tippler B, Ott J, Popowicz GM, Schliebs W, Sattler M, Erdmann R, Kalel VC (2021) Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction. Frontiers in cell and developmental biology, Vol. 9, 737159 DOI: 10.3389/fcell.2021.737159, PubMed: 34988071 |
Olguín-Contreras LF, Mendler AN, Popowicz G, Hu B, Noessner E (2021) Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy. Frontiers in immunology, Vol. 12, 750478 DOI: 10.3389/fimmu.2021.750478, PubMed: 34912334 |
Borchard S, Raschke S, Zak KM, Eberhagen C, Einer C, Weber E, Müller SM, Michalke B, Lichtmannegger J, Wieser A, Rieder T, Popowicz GM, Adamski J, Klingenspor M, Coles AH, Viana R, Vendelbo MH, Sandahl TD, Schwerdtle T, Plitz T, Zischka H (2022) Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage. Life science alliance, Issue 3, Vol. 5 DOI: 10.26508/lsa.202101164, PubMed: 34857647 |
Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, Sattler M, Prabu JR, Sidhu SS, Schulman BA (2022) Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. Journal of molecular biology, Issue 2, Vol. 434, 167347 DOI: 10.1016/j.jmb.2021.167347, PubMed: 34767800 |
Fino R, Lenhart D, Kalel VC, Softley CA, Napolitano V, Byrne R, Schliebs W, Dawidowski M, Erdmann R, Sattler M, Schneider G, Plettenburg O, Popowicz GM (2021) Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents. Journal of chemical information and modeling, Issue 10, Vol. 61, 5256-5268 DOI: 10.1021/acs.jcim.1c00472, PubMed: 34597510 |
Reyes Romero A, Lunev S, Popowicz GM, Calderone V, Gentili M, Sattler M, Plewka J, Taube M, Kozak M, Holak TA, Dömling ASS, Groves MR (2021) A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity. Communications biology, Issue 1, Vol. 4, 949 DOI: 10.1038/s42003-021-02442-1, PubMed: 34376783 |
Zak KM, Bostock MJ, Waligorska I, Thøgersen IB, Enghild JJ, Popowicz GM, Grudnik P, Potempa J, Ksiazek M (2021) Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia. Journal of enzyme inhibition and medicinal chemistry, Issue 1, Vol. 36, 1267-1281 DOI: 10.1080/14756366.2021.1937619, PubMed: 34210221 |
Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A (2021) Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds. Journal of medicinal chemistry, Issue 8, Vol. 64, 4623-4661 DOI: 10.1021/acs.jmedchem.0c02094, PubMed: 33818106 |
Kolonko M, Bystranowska D, Taube M, Kozak M, Bostock M, Popowicz G, Ożyhar A, Greb-Markiewicz B (2020) The intrinsically disordered region of GCE protein adopts a more fixed structure by interacting with the LBD of the nuclear receptor FTZ-F1. Cell communication and signaling : CCS, Issue 1, Vol. 18, 180 DOI: 10.1186/s12964-020-00662-2, PubMed: 33153474 |
Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM (2020) Correction for Softley et al., "Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase". Antimicrobial agents and chemotherapy, Issue 7, Vol. 64 DOI: 10.1128/AAC.01077-20, PubMed: 32576598 |
Softley CA, Bostock MJ, Popowicz GM, Sattler M (2020) Paramagnetic NMR in drug discovery. Journal of biomolecular NMR, Issue 6-7, Vol. 74, 287-309 DOI: 10.1007/s10858-020-00322-0, PubMed: 32524233 |
Encarnação JC, Napolitano V, Opassi G, Danielson UH, Dubin G, Popowicz GM, Munier-Lehmann H, Buijs J, Andersson K, Björkelund H (2020) A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells. FEBS letters, Issue 15, Vol. 594, 2406-2420 DOI: 10.1002/1873-3468.13847, PubMed: 32473599 |
Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM (2020) Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase. Antimicrobial agents and chemotherapy, Issue 6, Vol. 64, e00123-20 DOI: 10.1128/AAC.00123-20, PubMed: 32205343 |
Ratkova EL, Dawidowski M, Napolitano V, Dubin G, Fino R, Ostertag MS, Sattler M, Popowicz G, Tetko IV (2020) Water envelope has a critical impact on the design of protein-protein interaction inhibitors. Chemical communications (Cambridge, England), Issue 31, Vol. 56, 4360-4363 DOI: 10.1039/c9cc07714f, PubMed: 32195483 |
Dawidowski M, Król M, Szulczyk B, Chodkowski A, Podsadni P, Konopelski P, Ufnal M, Szuberski P, Wróbel MZ, Zhang Y, El Harchi A, Hancox JC, Jarkovska D, Mistrova E, Sviglerova J, Štengl M, Popowicz GM, Turło J (2020) Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide. Bioorganic chemistry, Vol. 98, 103717 DOI: 10.1016/j.bioorg.2020.103717, PubMed: 32171994 |
Denis M, Softley C, Giuntini S, Gentili M, Ravera E, Parigi G, Fragai M, Popowicz G, Sattler M, Luchinat C, Cerofolini L, Nativi C (2020) The Photocatalyzed Thiol-ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins. Chemphyschem : a European journal of chemical physics and physical chemistry, Issue 9, Vol. 21, 863-869 DOI: 10.1002/cphc.202000071, PubMed: 32092218 |
Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM (2020) Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity. Journal of medicinal chemistry, Issue 2, Vol. 63, 847-879 DOI: 10.1021/acs.jmedchem.9b01876, PubMed: 31860309 |
Xia Z, Karpov P, Popowicz G, Tetko IV (2020) Focused Library Generator: case of Mdmx inhibitors. Journal of computer-aided molecular design, Issue 7, Vol. 34, 769-782 DOI: 10.1007/s10822-019-00242-8, PubMed: 31677002 |
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M (2019) FSP1 is a glutathione-independent ferroptosis suppressor. Nature, Issue 7784, Vol. 575, 693-698 DOI: 10.1038/s41586-019-1707-0, PubMed: 31634899 |
Zak KM, Kalińska M, Wątor E, Kuśka K, Krutyhołowa R, Dubin G, Popowicz GM, Grudnik P (2019) Crystal Structure of Kluyveromyces lactis Glucokinase (KlGlk1). International journal of molecular sciences, Issue 19, Vol. 20 DOI: 10.3390/ijms20194821, PubMed: 31569356 |
Ostertag MS, Hutwelker W, Plettenburg O, Sattler M, Popowicz GM (2019) Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants. Journal of molecular biology, Issue 11, Vol. 431, 2213-2221 DOI: 10.1016/j.jmb.2019.04.017, PubMed: 31026449 |
Huang W, Lan D, Popowicz GM, Zak KM, Zhao Z, Yuan H, Yang B, Wang Y (2019) Structure and characterization of Aspergillus fumigatus lipase B with a unique, oversized regulatory subdomain. The FEBS journal, Issue 12, Vol. 286, 2366-2380 DOI: 10.1111/febs.14814, PubMed: 30908847 |
Kalel VC, Mäser P, Sattler M, Erdmann R, Popowicz GM (2018) Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development. Current opinion in microbiology, Vol. 46, 116-122 DOI: 10.1016/j.mib.2018.11.003, PubMed: 30481613 |
Ostertag MS, Messias AC, Sattler M, Popowicz GM (2019) The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation. Structure (London, England : 1993), Issue 2, Vol. 27, 327-334.e3 DOI: 10.1016/j.str.2018.10.005, PubMed: 30449689 |
Pabis M, Popowicz GM, Stehle R, Fernández-Ramos D, Asami S, Warner L, García-Mauriño SM, Schlundt A, Martínez-Chantar ML, Díaz-Moreno I, Sattler M (2019) HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs. Nucleic acids research, Issue 2, Vol. 47, 1011-1029 DOI: 10.1093/nar/gky1138, PubMed: 30418581 |
Pustuła M, Czub M, Łabuzek B, Surmiak E, Tomala M, Twarda-Clapa A, Guzik K, Popowicz GM, Holak TA (2019) NMR fragment-based screening for development of the CD44-binding small molecules. Bioorganic chemistry, Vol. 82, 284-289 DOI: 10.1016/j.bioorg.2018.10.043, PubMed: 30396062 |
Brenke JK, Popowicz GM, Schorpp K, Rothenaigner I, Roesner M, Meininger I, Kalinski C, Ringelstetter L, R'kyek O, Jürjens G, Vincendeau M, Plettenburg O, Sattler M, Krappmann D, Hadian K (2018) Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity. The Journal of biological chemistry, Issue 34, Vol. 293, 13191-13203 DOI: 10.1074/jbc.RA118.002649, PubMed: 29950522 |
Tomala MD, Magiera-Mularz K, Kubica K, Krzanik S, Zieba B, Musielak B, Pustula M, Popowicz GM, Sattler M, Dubin G, Skalniak L, Holak TA (2018) Identification of small-molecule inhibitors of USP2a. European journal of medicinal chemistry, Vol. 150, 261-267 DOI: 10.1016/j.ejmech.2018.03.009, PubMed: 29529503 |
Kalel VC, Emmanouilidis L, Dawidowski M, Schliebs W, Sattler M, Popowicz GM, Erdmann R (2017) Inhibitors of glycosomal protein import provide new leads against trypanosomiasis. Microbial cell (Graz, Austria), Issue 7, Vol. 4, 229-232 DOI: 10.15698/mic2017.07.581, PubMed: 28706938 |
Zhou P, Lan D, Popowicz GM, Wang X, Yang B, Wang Y (2017) Enhancing H2O2 resistance of an esterase from Pyrobaculum calidifontis by structure-guided engineering of the substrate binding site. Applied microbiology and biotechnology, Issue 14, Vol. 101, 5689-5697 DOI: 10.1007/s00253-017-8299-0, PubMed: 28516207 |
Corvino A, Severino B, Fiorino F, Frecentese F, Magli E, Perissutti E, Santagada V, Bucci M, Cirino G, Kelly G, Servillo L, Popowicz G, Pastore A, Caliendo G (2016) Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Scientific reports, Vol. 6, 34398 DOI: 10.1038/srep34398, PubMed: 27708394 |
Bolz C, Bach NC, Meyer H, Müller G, Dawidowski M, Popowicz G, Sieber SA, Skerra A, Gerhard M (2017) Comparison of enzymatic properties and small molecule inhibition of γ-glutamyltranspeptidases from pathogenic and commensal bacteria. Biological chemistry, Issue 3, Vol. 398, 341-357 DOI: 10.1515/hsz-2016-0198, PubMed: 27636829 |
Guo S, Popowicz GM, Li D, Yuan D, Wang Y (2016) Lid mobility in lipase SMG1 validated using a thiol/disulfide redox potential probe. FEBS open bio, Issue 5, Vol. 6, 477-83 DOI: 10.1002/2211-5463.12059, PubMed: 27419053 |
Golestanian S, Sharifi A, Popowicz GM, Azizian H, Foroumadi A, Szwagierczak A, Holak TA, Amanlou M (2016) Discovery of novel dual inhibitors against Mdm2 and Mdmx proteins by in silico approaches and binding assay. Life sciences, Vol. 145, 240-6 DOI: 10.1016/j.lfs.2015.12.047, PubMed: 26746660 |
Lan D, Wang Q, Popowicz GM, Yang B, Tang Q, Wang Y (2015) The Role of Residues 103, 104, and 278 in the Activity of SMG1 Lipase from Malassezia globosa: A Site-Directed Mutagenesis Study. Journal of microbiology and biotechnology, Issue 11, Vol. 25, 1827-34 DOI: 10.4014/jmb.1506.06079, PubMed: 26239010 |
Haslbeck V, Drazic A, Eckl JM, Alte F, Helmuth M, Popowicz G, Schmidt W, Braun F, Weiwad M, Fischer G, Gemmecker G, Sattler M, Striggow F, Groll M, Richter K (2015) Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism. Bioscience reports, Issue 3, Vol. 35 DOI: 10.1042/BSR20150042, PubMed: 26182372 |
Lan D, Popowicz GM, Pavlidis IV, Zhou P, Bornscheuer UT, Wang Y (2015) Conversion of a Mono- and Diacylglycerol Lipase into a Triacylglycerol Lipase by Protein Engineering. Chembiochem : a European journal of chemical biology, Issue 10, Vol. 16, 1431-4 DOI: 10.1002/cbic.201500163, PubMed: 25955297 |
Wang X, Tang Q, Popowicz GM, Yang B, Wang Y (2015) A mechanistic study into the epoxidation of carboxylic acid and alkene in a mono, di-acylglycerol lipase. Biochemical and biophysical research communications, Issue 2, Vol. 460, 392-6 DOI: 10.1016/j.bbrc.2015.03.044, PubMed: 25783054 |
Hennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M (2014) Structural basis for the assembly of the Sxl-Unr translation regulatory complex. Nature, Issue 7526, Vol. 515, 287-90 DOI: 10.1038/nature13693, PubMed: 25209665 |
Ammon T, Mishra SK, Kowalska K, Popowicz GM, Holak TA, Jentsch S (2014) The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells. Journal of molecular cell biology, Issue 4, Vol. 6, 312-23 DOI: 10.1093/jmcb/mju026, PubMed: 24872507 |
Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G (2014) Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation. The Journal of biological chemistry, Issue 22, Vol. 289, 15544-53 DOI: 10.1074/jbc.M113.507616, PubMed: 24713703 |
Khoury K, Popowicz GM, Holak TA, Dömling A (2011) The p53-MDM2/MDMX axis - A chemotype perspective. MedChemComm, Vol. 2, 246-260 DOI: 10.1039/C0MD00248H, PubMed: 24466404 |
Huang Y, Wolf S, Beck B, Köhler LM, Khoury K, Popowicz GM, Goda SK, Subklewe M, Twarda A, Holak TA, Dömling A (2014) Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS chemical biology, Issue 3, Vol. 9, 802-11 DOI: 10.1021/cb400728e, PubMed: 24405416 |
Burchacka E, Zdzalik M, Niemczyk JS, Pustelny K, Popowicz G, Wladyka B, Dubin A, Potempa J, Sienczyk M, Dubin G, Oleksyszyn J (2014) Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus. Protein science : a publication of the Protein Society, Issue 2, Vol. 23, 179-89 DOI: 10.1002/pro.2403, PubMed: 24375505 |
Bista M, Wolf S, Khoury K, Kowalska K, Huang Y, Wrona E, Arciniega M, Popowicz GM, Holak TA, Dömling A (2013) Transient protein states in designing inhibitors of the MDM2-p53 interaction. Structure (London, England : 1993), Issue 12, Vol. 21, 2143-51 DOI: 10.1016/j.str.2013.09.006, PubMed: 24207125 |
Baek S, Kang NJ, Popowicz GM, Arciniega M, Jung SK, Byun S, Song NR, Heo YS, Kim BY, Lee HJ, Holak TA, Augustin M, Bode AM, Huber R, Dong Z, Lee KW (2013) Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. Journal of molecular biology, Issue 2, Vol. 425, 411-23 DOI: 10.1016/j.jmb.2012.10.019, PubMed: 23142567 |
Koes D, Khoury K, Huang Y, Wang W, Bista M, Popowicz GM, Wolf S, Holak TA, Dömling A, Camacho CJ (2012) Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. PloS one, Issue 3, Vol. 7, e32839 DOI: 10.1371/journal.pone.0032839, PubMed: 22427896 |
Baek S, Kutchukian PS, Verdine GL, Huber R, Holak TA, Lee KW, Popowicz GM (2012) Structure of the stapled p53 peptide bound to Mdm2. Journal of the American Chemical Society, Issue 1, Vol. 134, 103-6 DOI: 10.1021/ja2090367, PubMed: 22148351 |
Huang Y, Wolf S, Koes D, Popowicz GM, Camacho CJ, Holak TA, Dömling A (2012) Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists. ChemMedChem, Issue 1, Vol. 7, 49-52 DOI: 10.1002/cmdc.201100428, PubMed: 21954050 |
Mishra SK, Ammon T, Popowicz GM, Krajewski M, Nagel RJ, Ares Jr M, Holak TA, Jentsch S (2011) Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature, Issue 7350, Vol. 474, 173-8 DOI: 10.1038/nature10143, PubMed: 21614000 |
Popowicz GM, Dömling A, Holak TA (2011) The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. Angewandte Chemie (International ed. in English), Issue 12, Vol. 50, 2680-8 DOI: 10.1002/anie.201003863, PubMed: 21341346 |
Czarna A, Beck B, Srivastava S, Popowicz GM, Wolf S, Huang Y, Bista M, Holak TA, Dömling A (2010) Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. Angewandte Chemie (International ed. in English), Issue 31, Vol. 49, 5352-6 DOI: 10.1002/anie.201001343, PubMed: 20575124 |
Ducka AM, Joel P, Popowicz GM, Trybus KM, Schleicher M, Noegel AA, Huber R, Holak TA, Sitar T (2010) Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proceedings of the National Academy of Sciences of the United States of America, Issue 26, Vol. 107, 11757-62 DOI: 10.1073/pnas.1005347107, PubMed: 20538977 |
Popowicz GM, Czarna A, Wolf S, Wang K, Wang W, Dömling A, Holak TA (2010) Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell cycle (Georgetown, Tex.), Issue 6, Vol. 9, 1104-11 DOI: 10.4161/cc.9.6.10956, PubMed: 20237429 |
Szwagierczak A, Antonenka U, Popowicz GM, Sitar T, Holak TA, Rakin A (2009) Structures of the arm-type binding domains of HPI and HAI7 integrases. The Journal of biological chemistry, Issue 46, Vol. 284, 31664-71 DOI: 10.1074/jbc.M109.059261, PubMed: 19737930 |
Czarna A, Popowicz GM, Pecak A, Wolf S, Dubin G, Holak TA (2009) High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell cycle (Georgetown, Tex.), Issue 8, Vol. 8, 1176-84 DOI: 10.4161/cc.8.8.8185, PubMed: 19305137 |
Stec-Niemczyk J, Pustelny K, Kisielewska M, Bista M, Boulware KT, Stennicke HR, Thogersen IB, Daugherty PS, Enghild JJ, Baczynski K, Popowicz GM, Dubin A, Potempa J, Dubin G (2009) Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus. The Biochemical journal, Issue 3, Vol. 419, 555-64 DOI: 10.1042/BJ20081351, PubMed: 19175361 |
Zuckerman V, Lenos K, Popowicz GM, Silberman I, Grossman T, Marine JC, Holak TA, Jochemsen AG, Haupt Y (2009) c-Abl phosphorylates Hdmx and regulates its interaction with p53. The Journal of biological chemistry, Issue 6, Vol. 284, 4031-9 DOI: 10.1074/jbc.M809211200, PubMed: 19075013 |
Rothweiler U, Czarna A, Weber L, Popowicz GM, Brongel K, Kowalska K, Orth M, Stemmann O, Holak TA (2008) NMR screening for lead compounds using tryptophan-mutated proteins. Journal of medicinal chemistry, Issue 16, Vol. 51, 5035-42 DOI: 10.1021/jm8002813, PubMed: 18680271 |
Popowicz GM, Czarna A, Holak TA (2008) Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell cycle (Georgetown, Tex.), Issue 15, Vol. 7, 2441-3 DOI: 10.4161/cc.6365, PubMed: 18677113 |
Dubin G, Stec-Niemczyk J, Kisielewska M, Pustelny K, Popowicz GM, Bista M, Kantyka T, Boulware KT, Stennicke HR, Czarna A, Phopaisarn M, Daugherty PS, Thøgersen IB, Enghild JJ, Thornberry N, Dubin A, Potempa J (2008) Enzymatic activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln. Journal of molecular biology, Issue 2, Vol. 379, 343-56 DOI: 10.1016/j.jmb.2008.03.059, PubMed: 18448121 |
Popowicz GM, Czarna A, Rothweiler U, Szwagierczak A, Krajewski M, Weber L, Holak TA (2007) Molecular basis for the inhibition of p53 by Mdmx. Cell cycle (Georgetown, Tex.), Issue 19, Vol. 6, 2386-92 DOI: 10.4161/cc.6.19.4740, PubMed: 17938582 |
Singh M, Popowicz GM, Krajewski M, Holak TA (2007) Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex. Chembiochem : a European journal of chemical biology, Issue 11, Vol. 8, 1308-16 DOI: 10.1002/cbic.200600562, PubMed: 17582821 |
Verdoodt B, Benzinger A, Popowicz GM, Holak TA, Hermeking H (2006) Characterization of 14-3-3sigma dimerization determinants: requirement of homodimerization for inhibition of cell proliferation. Cell cycle (Georgetown, Tex.), Issue 24, Vol. 5, 2920-6 DOI: 10.4161/cc.5.24.3571, PubMed: 17172876 |
Sitar T, Popowicz GM, Siwanowicz I, Huber R, Holak TA (2006) Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proceedings of the National Academy of Sciences of the United States of America, Issue 35, Vol. 103, 13028-33 DOI: 10.1073/pnas.0605652103, PubMed: 16924115 |
Popowicz GM, Schleicher M, Noegel AA, Holak TA (2006) Filamins: promiscuous organizers of the cytoskeleton. Trends in biochemical sciences, Issue 7, Vol. 31, 411-9 DOI: 10.1016/j.tibs.2006.05.006, PubMed: 16781869 |
Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA (2006) Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. Journal of molecular biology, Issue 4, Vol. 359, 863-75 DOI: 10.1016/j.jmb.2006.03.070, PubMed: 16690081 |
Popowicz GM, Dubin G, Stec-Niemczyk J, Czarny A, Dubin A, Potempa J, Holak TA (2006) Functional and structural characterization of Spl proteases from Staphylococcus aureus. Journal of molecular biology, Issue 1, Vol. 358, 270-9 DOI: 10.1016/j.jmb.2006.01.098, PubMed: 16516230 |
Arolas JL, Popowicz GM, Bronsoms S, Aviles FX, Huber R, Holak TA, Ventura S (2005) Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond. Journal of molecular biology, Issue 4, Vol. 352, 961-75 DOI: 10.1016/j.jmb.2005.07.065, PubMed: 16126224 |
Arolas JL, D'Silva L, Popowicz GM, Aviles FX, Holak TA, Ventura S (2005) NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor. Structure (London, England : 1993), Issue 8, Vol. 13, 1193-202 DOI: 10.1016/j.str.2005.05.008, PubMed: 16084391 |
Arolas JL, Popowicz GM, Lorenzo J, Sommerhoff CP, Huber R, Aviles FX, Holak TA (2005) The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode. Journal of molecular biology, Issue 3, Vol. 350, 489-98 DOI: 10.1016/j.jmb.2005.05.015, PubMed: 15961103 |
Benzinger A, Popowicz GM, Joy JK, Majumdar S, Holak TA, Hermeking H (2005) The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell research, Issue 4, Vol. 15, 219-27 DOI: 10.1038/sj.cr.7290290, PubMed: 15857576 |
Siwanowicz I, Popowicz GM, Wisniewska M, Huber R, Kuenkele KP, Lang K, Engh RA, Holak TA (2005) Structural basis for the regulation of insulin-like growth factors by IGF binding proteins. Structure (London, England : 1993), Issue 1, Vol. 13, 155-67 DOI: 10.1016/j.str.2004.11.009, PubMed: 15642270 |
Popowicz GM, Müller R, Noegel AA, Schleicher M, Huber R, Holak TA (2004) Molecular structure of the rod domain of dictyostelium filamin. Journal of molecular biology, Issue 5, Vol. 342, 1637-46 DOI: 10.1016/j.jmb.2004.08.017, PubMed: 15364587 |
Mavoungou C, Israel L, Rehm T, Ksiazek D, Krajewski M, Popowicz G, Noegel AA, Schleicher M, Holak TA (2004) NMR structural characterization of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum. Journal of biomolecular NMR, Issue 1, Vol. 29, 73-84 DOI: 10.1023/B:JNMR.0000019513.86120.98, PubMed: 15017141 |
Dubin G, Popowicz G, Krajewski M, Potempa J, Dubin A, Holak TA (2004) 1H, 15N and 13C NMR resonance assignments of staphostatin A, a specific Staphylococcus aureus cysteine proteinase inhibitor. Journal of biomolecular NMR, Issue 3, Vol. 28, 295-6 DOI: 10.1023/B:JNMR.0000013681.37659.24, PubMed: 14752262 |
Dubin G, Krajewski M, Popowicz G, Stec-Niemczyk J, Bochtler M, Potempa J, Dubin A, Holak TA (2003) A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus. Biochemistry, Issue 46, Vol. 42, 13449-56 DOI: 10.1021/bi035310j, PubMed: 14621990 |