Kogut-Günthel MM, Zara Z, Nicoli A, Steuer A, Lopez-Balastegui M, Selent J, Karanth S, Koehler M, Ciancetta A, Abiko LA, Hagn F, Di Pizio A (2024)
The path to the G protein-coupled receptor structural landscape: Major milestones and future directions.
British journal of pharmacology
DOI: 10.1111/bph.17314, PubMed: 39209310

Leitl KD, Sperl LE, Hagn F (2024)
Preferred inhibition of pro-apoptotic Bak by BclxL via a two-step mechanism.
Cell reports, Issue 8, Vol. 43, 114526
DOI: 10.1016/j.celrep.2024.114526, PubMed: 39046879

Daniilidis M, Sperl LE, Müller BS, Babl A, Hagn F (2024)
Efficient Segmental Isotope Labeling of Integral Membrane Proteins for High-Resolution NMR Studies.
Journal of the American Chemical Society, Issue 22, Vol. 146, 15403-15410
DOI: 10.1021/jacs.4c03294, PubMed: 38787792

Günsel U, Klöpfer K, Häusler E, Hitzenberger M, Bölter B, Sperl LE, Zacharias M, Soll J, Hagn F (2023)
Structural basis of metabolite transport by the chloroplast outer envelope channel OEP21.
Nature structural & molecular biology, Issue 6, Vol. 30, 761-769
DOI: 10.1038/s41594-023-00984-y, PubMed: 37156968

Mohamadi M, Goricanec D, Wagner G, Hagn F (2023)
NMR sample optimization and backbone assignment of a stabilized neurotensin receptor.
Journal of structural biology, Issue 2, Vol. 215, 107970
DOI: 10.1016/j.jsb.2023.107970, PubMed: 37142193

Daniilidis M, Brandl MJ, Hagn F (2022)
The Advanced Properties of Circularized MSP Nanodiscs Facilitate High-resolution NMR Studies of Membrane Proteins.
Journal of molecular biology, Issue 24, Vol. 434, 167861
DOI: 10.1016/j.jmb.2022.167861, PubMed: 36273602

Opdensteinen P, Sperl LE, Mohamadi M, Kündgen-Redding N, Hagn F, Buyel JF (2022)
The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labelling for NMR spectroscopy.
Plant biotechnology journal, Issue 10, Vol. 20, 1928-1939
DOI: 10.1111/pbi.13873, PubMed: 35702941

Schuhmann P, Engstler C, Klöpfer K, Gügel IL, Abbadi A, Dreyer F, Leckband G, Bölter B, Hagn F, Soll J, Carrie C (2022)
Two wrongs make a right: heat stress reversion of a male-sterile Brassica napus line.
Journal of experimental botany, Issue 11, Vol. 73, 3531-3551
DOI: 10.1093/jxb/erac082, PubMed: 35226731

Günsel U, Hagn F (2022)
Lipid Nanodiscs for High-Resolution NMR Studies of Membrane Proteins.
Chemical reviews, Issue 10, Vol. 122, 9395-9421
DOI: 10.1021/acs.chemrev.1c00702, PubMed: 34665588

Sperl LE, Rührnößl F, Schiller A, Haslbeck M, Hagn F (2021)
High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.
The EMBO journal, Issue 20, Vol. 40, e107159
DOI: 10.15252/embj.2020107159, PubMed: 34523144

Sperl LE, Hagn F (2021)
NMR Structural and Biophysical Analysis of the Disease-Linked Inner Mitochondrial Membrane Protein MPV17.
Journal of molecular biology, Issue 15, Vol. 433, 167098
DOI: 10.1016/j.jmb.2021.167098, PubMed: 34116124

Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML, Wagner G (2021)
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nature structural & molecular biology, Issue 3, Vol. 28, 258-267
DOI: 10.1038/s41594-020-00554-6, PubMed: 33633398

Goba I, Goricanec D, Schum D, Hillenbrand M, Plückthun A, Hagn F (2021)
Probing the Conformation States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling.
Chembiochem : a European journal of chemical biology, Issue 1, Vol. 22, 139-146
DOI: 10.1002/cbic.202000541, PubMed: 32881260

Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C, Hagn F (2020)
γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.
The EMBO journal, Issue 20, Vol. 39, e104247
DOI: 10.15252/embj.2019104247, PubMed: 32830336

Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Kläger S, Küster B, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perocchi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D (2020)
Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
Journal of hepatology, Issue 6, Vol. 73, 1347-1359
DOI: 10.1016/j.jhep.2020.06.026, PubMed: 32598967

Häusler E, Fredriksson K, Goba I, Peters C, Raltchev K, Sperl L, Steiner A, Weinkauf S, Hagn F (2020)
Quantifying the insertion of membrane proteins into lipid bilayer nanodiscs using a fusion protein strategy.
Biochimica et biophysica acta. Biomembranes, Issue 4, Vol. 1862, 183190
DOI: 10.1016/j.bbamem.2020.183190, PubMed: 31935366

Klöpfer K, Hagn F (2019)
Beyond detergent micelles: The advantages and applications of non-micellar and lipid-based membrane mimetics for solution-state NMR.
Progress in nuclear magnetic resonance spectroscopy, Vol. 114-115, 271-283
DOI: 10.1016/j.pnmrs.2019.08.001, PubMed: 31779883

Hassan L, Lin L, Sorek H, Sperl LE, Goudoulas T, Hagn F, Germann N, Tian C, Benz JP (2019)
Crosstalk of Cellulose and Mannan Perception Pathways Leads to Inhibition of Cellulase Production in Several Filamentous Fungi.
mBio, Issue 4, Vol. 10
DOI: 10.1128/mBio.00277-19, PubMed: 31266859

Zeng B, Mou TC, Doukov TI, Steiner A, Yu W, Papasergi-Scott M, Tall GG, Hagn F, Sprang SR (2019)
Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A.
Structure (London, England : 1993), Issue 7, Vol. 27, 1137-1147.e5
DOI: 10.1016/j.str.2019.04.013, PubMed: 31155309

Goricanec D, Hagn F (2019)
NMR backbone and methyl resonance assignments of an inhibitory G-alpha subunit in complex with GDP.
Biomolecular NMR assignments, Issue 1, Vol. 13, 131-137
DOI: 10.1007/s12104-018-9865-9, PubMed: 30539422

Reif MM, Fischer M, Fredriksson K, Hagn F, Zacharias M (2019)
The N-Terminal Segment of the Voltage-Dependent Anion Channel: A Possible Membrane-Bound Intermediate in Pore Unbinding.
Journal of molecular biology, Issue 2, Vol. 431, 223-243
DOI: 10.1016/j.jmb.2018.09.015, PubMed: 30339869

Miehling J, Goricanec D, Hagn F (2018)
A Split-Intein-Based Method for the Efficient Production of Circularized Nanodiscs for Structural Studies of Membrane Proteins.
Chembiochem : a European journal of chemical biology, Issue 18, Vol. 19, 1927-1933
DOI: 10.1002/cbic.201800345, PubMed: 29947468

Raltchev K, Pipercevic J, Hagn F (2018)
Production and Structural Analysis of Membrane-Anchored Proteins in Phospholipid Nanodiscs.
Chemistry (Weinheim an der Bergstrasse, Germany), Issue 21, Vol. 24, 5493-5499
DOI: 10.1002/chem.201800812, PubMed: 29457664

Hagn F, Nasr ML, Wagner G (2018)
Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR.
Nature protocols, Issue 1, Vol. 13, 79-98
DOI: 10.1038/nprot.2017.094, PubMed: 29215632

Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B, Ramamoorthy A (2017)
Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate.
eLife, Vol. 6
DOI: 10.7554/eLife.31226, PubMed: 29148426

Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G (2017)
Covalently circularized nanodiscs for studying membrane proteins and viral entry.
Nature methods, Issue 1, Vol. 14, 49-52
DOI: 10.1038/nmeth.4079, PubMed: 27869813

Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G, Hagn F (2016)
Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding.
Proceedings of the National Academy of Sciences of the United States of America, Issue 26, Vol. 113, E3629-38
DOI: 10.1073/pnas.1604125113, PubMed: 27298341

Enthart A, Klein C, Dehner A, Coles M, Gemmecker G, Kessler H, Hagn F (2016)
Solution structure and binding specificity of the p63 DNA binding domain.
Scientific reports, Vol. 6, 26707
DOI: 10.1038/srep26707, PubMed: 27225672

Milbradt AG, Arthanari H, Takeuchi K, Boeszoermenyi A, Hagn F, Wagner G (2015)
Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY.
Journal of biomolecular NMR, Issue 3, Vol. 62, 291-301
DOI: 10.1007/s10858-015-9944-5, PubMed: 25957757

Hagn F, Wagner G (2015)
Structure refinement and membrane positioning of selectively labeled OmpX in phospholipid nanodiscs.
Journal of biomolecular NMR, Issue 3-4, Vol. 61, 249-60
DOI: 10.1007/s10858-014-9883-6, PubMed: 25430058

Linser R, Gelev V, Hagn F, Arthanari H, Hyberts SG, Wagner G (2014)
Selective methyl labeling of eukaryotic membrane proteins using cell-free expression.
Journal of the American Chemical Society, Issue 32, Vol. 136, 11308-10
DOI: 10.1021/ja504791j, PubMed: 24937763

Etzkorn M, Raschle T, Hagn F, Gelev V, Rice AJ, Walz T, Wagner G (2013)
Cell-free expressed bacteriorhodopsin in different soluble membrane mimetics: biophysical properties and NMR accessibility.
Structure (London, England : 1993), Issue 3, Vol. 21, 394-401
DOI: 10.1016/j.str.2013.01.005, PubMed: 23415558

Hagn F, Etzkorn M, Raschle T, Wagner G (2013)
Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins.
Journal of the American Chemical Society, Issue 5, Vol. 135, 1919-25
DOI: 10.1021/ja310901f, PubMed: 23294159

Demmer O, Frank AO, Hagn F, Schottelius M, Marinelli L, Cosconati S, Brack-Werner R, Kremb S, Wester HJ, Kessler H (2012)
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity.
Angewandte Chemie (International ed. in English), Issue 32, Vol. 51, 8110-3
DOI: 10.1002/anie.201202090, PubMed: 22760863

Hagn F (2012)
A structural view on spider silk proteins and their role in fiber assembly.
Journal of peptide science : an official publication of the European Peptide Society, Issue 6, Vol. 18, 357-65
DOI: 10.1002/psc.2417, PubMed: 22570231

Schmid AB, Lagleder S, Gräwert MA, Röhl A, Hagn F, Wandinger SK, Cox MB, Demmer O, Richter K, Groll M, Kessler H, Buchner J (2012)
The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
The EMBO journal, Issue 6, Vol. 31, 1506-17
DOI: 10.1038/emboj.2011.472, PubMed: 22227520

Hagn F, Lagleder S, Retzlaff M, Rohrberg J, Demmer O, Richter K, Buchner J, Kessler H (2011)
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
Nature structural & molecular biology, Issue 10, Vol. 18, 1086-93
DOI: 10.1038/nsmb.2114, PubMed: 21892170

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR (2011)
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
Circulation research, Issue 7, Vol. 109, 758-69
DOI: 10.1161/CIRCRESAHA.111.245787, PubMed: 21799151

Hagn F, Thamm C, Scheibel T, Kessler H (2011)
pH-dependent dimerization and salt-dependent stabilization of the N-terminal domain of spider dragline silk--implications for fiber formation.
Angewandte Chemie (International ed. in English), Issue 1, Vol. 50, 310-3
DOI: 10.1002/anie.201003795, PubMed: 21064058

Welker S, Rudolph B, Frenzel E, Hagn F, Liebisch G, Schmitz G, Scheuring J, Kerth A, Blume A, Weinkauf S, Haslbeck M, Kessler H, Buchner J (2010)
Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function.
Molecular cell, Issue 4, Vol. 39, 507-20
DOI: 10.1016/j.molcel.2010.08.001, PubMed: 20797624

Hagn F, Eisoldt L, Hardy JG, Vendrely C, Coles M, Scheibel T, Kessler H (2010)
A conserved spider silk domain acts as a molecular switch that controls fibre assembly.
Nature, Issue 7295, Vol. 465, 239-42
DOI: 10.1038/nature08936, PubMed: 20463741

Retzlaff M, Hagn F, Mitschke L, Hessling M, Gugel F, Kessler H, Richter K, Buchner J (2010)
Asymmetric activation of the hsp90 dimer by its cochaperone aha1.
Molecular cell, Issue 3, Vol. 37, 344-54
DOI: 10.1016/j.molcel.2010.01.006, PubMed: 20159554

Hagn F, Klein C, Demmer O, Marchenko N, Vaseva A, Moll UM, Kessler H (2010)
BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain.
The Journal of biological chemistry, Issue 5, Vol. 285, 3439-50
DOI: 10.1074/jbc.M109.065391, PubMed: 19955567

Spichty M, Taly A, Hagn F, Kessler H, Barluenga S, Winssinger N, Karplus M (2009)
The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts.
Biophysical chemistry, Issue 3, Vol. 143, 111-23
DOI: 10.1016/j.bpc.2009.04.003, PubMed: 19482409

Feige MJ, Hagn F, Esser J, Kessler H, Buchner J (2007)
Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain.
Journal of molecular biology, Issue 4, Vol. 365, 1232-44
DOI: 10.1016/j.jmb.2006.10.049, PubMed: 17112539

Richter K, Moser S, Hagn F, Friedrich R, Hainzl O, Heller M, Schlee S, Kessler H, Reinstein J, Buchner J (2006)
Intrinsic inhibition of the Hsp90 ATPase activity.
The Journal of biological chemistry, Issue 16, Vol. 281, 11301-11
DOI: 10.1074/jbc.M510142200, PubMed: 16461354

Scholz C, Eckert B, Hagn F, Schaarschmidt P, Balbach J, Schmid FX (2006)
SlyD proteins from different species exhibit high prolyl isomerase and chaperone activities.
Biochemistry, Issue 1, Vol. 45, 20-33
DOI: 10.1021/bi051922n, PubMed: 16388577

Andersson A, Almqvist J, Hagn F, Mäler L (2004)
Diffusion and dynamics of penetratin in different membrane mimicking media.
Biochimica et biophysica acta, Issue 1, Vol. 1661, 18-25
DOI: 10.1016/j.bbamem.2003.11.014, PubMed: 14967471