Chin Sang C, Moore G, Tereshchenko M, Zhang H, Nosella ML, Dasovich M, Alderson TR, Leung AKL, Finkelstein IJ, Forman-Kay JD, Lee HO (2024)
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation.
EMBO reports
DOI: 10.1038/s44319-024-00285-5, PubMed: 39496836 |
Sang CC, Moore G, Tereshchenko M, Nosella ML, Zhang H, Alderson TR, Dasovich M, Leung A, Finkelstein IJ, Forman-Kay JD, Lee HO (2024)
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation.
bioRxiv : the preprint server for biology
DOI: 10.1101/2024.01.20.575817, PubMed: 38328070 |
Sever AIM, Alderson TR, Rennella E, Aramini JM, Liu ZH, Harkness RW, Kay LE (2023)
Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR.
Proceedings of the National Academy of Sciences of the United States of America, Issue 51, Vol. 120, e2310944120
DOI: 10.1073/pnas.2310944120, PubMed: 38085782 |
Alderson TR, Pritišanac I, Kolarić Đ, Moses AM, Forman-Kay JD (2023)
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2.
Proceedings of the National Academy of Sciences of the United States of America, Issue 44, Vol. 120, e2304302120
DOI: 10.1073/pnas.2304302120, PubMed: 37878721 |
Spreitzer E, Alderson TR, Bourgeois B, Eggenreich L, Habacher H, Brahmersdorfer G, Pritišanac I, Sánchez-Murcia PA, Madl T (2022)
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions.
Current research in structural biology, Vol. 4, 118-133
DOI: 10.1016/j.crstbi.2022.04.001, PubMed: 35573459 |
Alderson TR, Adriaenssens E, Asselbergh B, Pritišanac I, Van Lent J, Gastall HY, Wälti MA, Louis JM, Timmerman V, Baldwin AJ, Lp Benesch J (2021)
A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.
The EMBO journal, Issue 8, Vol. 40, e103811
DOI: 10.15252/embj.2019103811, PubMed: 33644875 |
Alderson TR, Kay LE (2021)
NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function.
Cell, Issue 3, Vol. 184, 577-595
DOI: 10.1016/j.cell.2020.12.034, PubMed: 33545034 |
Pritišanac I, Alderson TR, Güntert P (2020)
Automated assignment of methyl NMR spectra from large proteins.
Progress in nuclear magnetic resonance spectroscopy, Vol. 118-119, 54-73
DOI: 10.1016/j.pnmrs.2020.04.001, PubMed: 32883449 |
Ramanujam V, Alderson TR, Pritišanac I, Ying J, Bax A (2020)
Protein structural changes characterized by high-pressure, pulsed field gradient diffusion NMR spectroscopy.
Journal of magnetic resonance (San Diego, Calif. : 1997), Vol. 312, 106701
DOI: 10.1016/j.jmr.2020.106701, PubMed: 32113145 |
Alderson TR, Ying J, Bax A, Benesch JLP, Baldwin AJ (2020)
Conditional Disorder in Small Heat-shock Proteins.
Journal of molecular biology, Issue 9, Vol. 432, 3033-3049
DOI: 10.1016/j.jmb.2020.02.003, PubMed: 32081587 |
Alderson TR, Kay LE (2020)
Unveiling invisible protein states with NMR spectroscopy.
Current opinion in structural biology, Vol. 60, 39-49
DOI: 10.1016/j.sbi.2019.10.008, PubMed: 31835059 |
Pritišanac I, Würz JM, Alderson TR, Güntert P (2019)
Automatic structure-based NMR methyl resonance assignment in large proteins.
Nature communications, Issue 1, Vol. 10, 4922
DOI: 10.1038/s41467-019-12837-8, PubMed: 31664028 |
Collier MP, Alderson TR, de Villiers CP, Nicholls D, Gastall HY, Allison TM, Degiacomi MT, Jiang H, Mlynek G, Fürst DO, van der Ven PFM, Djinovic-Carugo K, Baldwin AJ, Watkins H, Gehmlich K, Benesch JLP (2019)
HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C.
Science advances, Issue 5, Vol. 5, eaav8421
DOI: 10.1126/sciadv.aav8421, PubMed: 31131323 |
Alderson TR, Roche J, Gastall HY, Dias DM, Pritišanac I, Ying J, Bax A, Benesch JLP, Baldwin AJ (2019)
Local unfolding of the HSP27 monomer regulates chaperone activity.
Nature communications, Issue 1, Vol. 10, 1068
DOI: 10.1038/s41467-019-08557-8, PubMed: 30842409 |
Charlier C, Courtney JM, Alderson TR, Anfinrud P, Bax A (2018)
Monitoring 15N Chemical Shifts During Protein Folding by Pressure-Jump NMR.
Journal of the American Chemical Society, Issue 26, Vol. 140, 8096-8099
DOI: 10.1021/jacs.8b04833, PubMed: 29923716 |
Charlier C, Alderson TR, Courtney JM, Ying J, Anfinrud P, Bax A (2018)
Study of protein folding under native conditions by rapidly switching the hydrostatic pressure inside an NMR sample cell.
Proceedings of the National Academy of Sciences of the United States of America, Issue 18, Vol. 115, E4169-E4178
DOI: 10.1073/pnas.1803642115, PubMed: 29666248 |
Alderson TR, Lee JH, Charlier C, Ying J, Bax A (2018)
Propensity for cis-Proline Formation in Unfolded Proteins.
Chembiochem : a European journal of chemical biology, Issue 1, Vol. 19, 37-42
DOI: 10.1002/cbic.201700548, PubMed: 29064600 |
Alderson TR, Charlier C, Torchia DA, Anfinrud P, Bax A (2017)
Monitoring Hydrogen Exchange During Protein Folding by Fast Pressure Jump NMR Spectroscopy.
Journal of the American Chemical Society, Issue 32, Vol. 139, 11036-11039
DOI: 10.1021/jacs.7b06676, PubMed: 28766333 |
Pritišanac I, Degiacomi MT, Alderson TR, Carneiro MG, Ab E, Siegal G, Baldwin AJ (2017)
Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory.
Journal of the American Chemical Society, Issue 28, Vol. 139, 9523-9533
DOI: 10.1021/jacs.6b11358, PubMed: 28691806 |
Alderson TR, Benesch JLP, Baldwin AJ (2017)
Proline isomerization in the C-terminal region of HSP27.
Cell stress & chaperones, Issue 4, Vol. 22, 639-651
DOI: 10.1007/s12192-017-0791-z, PubMed: 28547731 |
Alderson TR, Bax A (2016)
Parkinson's disease: Disorder in the court.
Nature, Issue 7588, Vol. 530, 38-9
DOI: 10.1038/nature16871, PubMed: 26808901 |
Kim JH, Bothe JR, Alderson TR, Markley JL (2015)
Tangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies.
Biochimica et biophysica acta, Issue 6, Vol. 1853, 1416-28
DOI: 10.1016/j.bbamcr.2014.11.020, PubMed: 25450980 |
Alderson TR, Kim JH, Cai K, Frederick RO, Tonelli M, Markley JL (2014)
The specialized Hsp70 (HscA) interdomain linker binds to its nucleotide-binding domain and stimulates ATP hydrolysis in both cis and trans configurations.
Biochemistry, Issue 46, Vol. 53, 7148-59
DOI: 10.1021/bi5010552, PubMed: 25372495 |
Kim JH, Alderson TR, Frederick RO, Markley JL (2014)
Nucleotide-dependent interactions within a specialized Hsp70/Hsp40 complex involved in Fe-S cluster biogenesis.
Journal of the American Chemical Society, Issue 33, Vol. 136, 11586-9
DOI: 10.1021/ja5055252, PubMed: 25080945 |
Alderson TR, Markley JL (2013)
Biophysical characterization of α-synuclein and its controversial structure.
Intrinsically disordered proteins, Issue 1, Vol. 1, 18-39
DOI: 10.4161/idp.26255, PubMed: 24634806 |
