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Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper-IgE Syndrome Likely by Impaired STAT3-Dimer Formation.
European journal of immunology, Issue 7, Vol. 55, e70015
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Sturla SJ, Dai J, Nomura DK, Wang Y, Juárez-Moreno K, Tetko IV, Gupta K (2025)
Introducing the Inaugural Early Career Board for Chemical Research in Toxicology.
Chemical research in toxicology, Issue 8, Vol. 38, 1283
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Pérez-Ràfols A, Pérez-Ropero G, Cerofolini L, Sperotto L, Roca-Martínez J, Higuera-Rodríguez RA, Russomanno P, Kaiser W, Vranken W, Danielson UH, Provenzani A, Martelli T, Sattler M, Buijs J, Fragai M (2025)
Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications.
Nucleic acids research, Issue 15, Vol. 53
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Tetko IV, Clevert DA (2025)
Advanced machine learning for innovative drug discovery.
Journal of cheminformatics, Issue 1, Vol. 17, 122
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Eytcheson SA, Tetko IV (2025)
Which Modern AI Methods Provide Accurate Predictions of Toxicological End Points? Analysis of Tox24 Challenge Results.
Chemical research in toxicology
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Roncaglioni A, Kovarich S, Mansouri K, Tetko IV (2025)
Advancing Human and Environmental Safety Science Using In Silico Methods.
Chemical research in toxicology, Issue 8, Vol. 38, 1281-1282
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Singh I, Onogi Y, Menezes F, Khasanova D, Kang L, Wang C, Ruiz-Trave J, Sharma S, Khalil A, Reichenbach VK, Shi Y, Flatley A, Yan X, Israel A, Dragano NRV, Aguilar-Pimentel JA, Hoffmann A, Ghosh A, Noé F, Wolfrum C, Cucuruz S, König AC, Burtscher I, Hauck SM, Lickert H, Hofmann SM, Feederle R, Schriever SC, Hernandez-Bautista R, Sancar G, Cebrian-Serrano A, Tetko I, Fuchs H, Gailus-Durner V, Blüher M, Hrabě de Angelis M, Ussar S (2025)
NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.
The EMBO journal
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Nowacki M, Menezes F, Pykacz E, Popiołek M, Napolitano V, Krishna CK, Kalel VC, Erdmann R, Fröhlich T, Plettenburg O, Sattler M, Popowicz GM, Dawidowski M (2025)
Quantum mechanics-driven structure-activity relationship study of PEX5-PEX14 protein-protein interaction inhibitors based on a dibenzo[b,e]azepin-6(6H)-one scaffold.
European journal of medicinal chemistry, Vol. 298, 117979
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Zhang F, Dorn T, Gnutti B, Anikster Y, Kuebler S, Ahrens-Nicklas R, Gosselin R, Rahman S, Durst R, Zanuttigh E, Güra MA, Poch CM, Meier AB, Laugwitz KL, Schüller HJ, Messias AC, Sibon OC, Finazzi D, Rippert A, Li D, Truxal K, Nandi D, Lampert BC, Yeo M, Gardham A, Nissan B, Horowitz Cederboim S, Moretti A, Iuso A (2025)
Pantethine ameliorates dilated cardiomyopathy features in PPCS deficiency disorder in patients and cell line models.
Communications medicine, Issue 1, Vol. 5, 323
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Waas D, Juraschitz M, Chen YA, Waltenberger H, Hammerschmidt W, Zeidler R, Molinaro S, Gärtner K (2025)
Development of Broadly Applicable Reference EVs Expressing Horseradish Peroxidase.
Journal of extracellular vesicles, Issue 8, Vol. 14, e70115
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Dürauer S, Kang HS, Wiebeler C, Machida Y, Schnapka DS, Yaneva D, Renz C, Götz MJ, Weickert P, Major AC, Rahmanto AS, Gutenthaler-Tietze SM, Daumann LJ, Beli P, Ulrich HD, Sattler M, Machida YJ, Schwierz N, Stingele J (2025)
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability.
Nature communications, Issue 1, Vol. 16, 5422
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Hipp C, Mussgnug S, Choudhary P, Kang HS, Asami S, Sastre J, Donau C, Böttcher R, Gemmecker G, Boekhoven J, Förstemann K, Sattler M (2025)
Molecular mechanisms of biomolecular condensate formation in Drosophila melanogaster siRNA biogenesis.
Nucleic acids research, Issue 14, Vol. 53
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Sahoo BR, Watanabe-Nakayama T, Suladze S, Anantharamaiah GM, Reif B, Ramamoorthy A (2025)
Bifunctional nanodisc platforms for studies on self-assembly and amyloid fibrillation.
Chemical communications (Cambridge, England), Issue 66, Vol. 61, 12349-12352
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Bérouti M, Wagner M, Greulich W, Piseddu I, Gärtig J, Hansbauer L, Müller-Hermes C, Heiss M, Pichler A, Tölke AJ, Witte G, Hopfner KP, Anz D, Sattler M, Carell T, Hornung V (2025)
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement.
Cell, Issue 18, Vol. 188, 4880-4895.e15
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Gaber T, Monecke T, Grabowski J, Simon B, Williams T, Roman V, Chao J, Hennig J, Ephrussi A, Niessing D, Heber S (2025)
A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C in the oskar mRNA transport complex.
Cell reports, Issue 7, Vol. 44, 115906
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Müller-Hermes C, Piomponi V, Hilber S, Asami S, Kreutz C, Bussi G, Sattler M (2025)
Unique conformational dynamics and protein recognition of A-to-I hyper-edited dsRNA.
Nucleic acids research, Issue 12, Vol. 53
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Walla B, Dietrich AM, Brames E, Bischoff D, Fritzsche S, Castiglione K, Janowski R, Niessing D, Weuster-Botz D (2025)
Application of a Rational Crystal Contact Engineering Strategy on a Poly(ethylene terephthalate)-Degrading Cutinase.
Bioengineering (Basel, Switzerland), Issue 6, Vol. 12
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Wilhelm A, Flynn C, Hammer E, Roessler J, Haller B, Napieralski R, Leuthner M, Tosheska S, Knoops K, Mathew A, Ciarimboli G, Kranich J, Flaskamp L, King S, Gevensleben H, Emslander Q, Pastucha A, Reisbeck M, Rief L, Bronger H, Dreyer T, Bausch AR, Pichlmair A, Brocker T, Zeidler R, Hammerschmidt W, Piedavent-Salomom M, López-Iglesias C, Schricker G, Haydn O, Kiechle M, Grill S, Heeren R, Knolle PA, Wilhelm O, Höchst B (2025)
Two-dimensional analysis of plasma-derived extracellular vesicles to determine the HER2 status in breast cancer patients.
Breast cancer research : BCR, Issue 1, Vol. 27, 107
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Rawal S, Kolarić Ð, Bohn S, Kolb D, Pavkov-Keller T, Pritišanac I, Madl T, Desfosses A, Alderson TR (2025)
A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD.
bioRxiv : the preprint server for biology
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Du Y, Lv X, Siebenmorgen T, Popowicz G, Feng C, Ma Y, Wang Y (2025)
Enhancing Catalytic Activity of a Baeyer-Villiger monooxygenase from Oceanicola granulosus: Simultaneous Engineering of the Distal Site and Active Site.
Journal of agricultural and food chemistry, Issue 23, Vol. 73, 14453-14466
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Wang Z, Cao G, Collier MP, Qiu X, Broadway-Stringer S, Šaman D, Ng JZY, Sen N, Azad AJ, Hooper C, Zimmermann J, McDonough MA, Brem J, Rabe P, Song H, Alderson TR, Schofield CJ, Bolla JR, Djinovic-Carugo K, Fürst DO, Warscheid B, Degiacomi MT, Allison TM, Hochberg GKA, Robinson CV, Gehmlich K, Benesch JLP (2025)
Filamin C dimerisation is regulated by HSPB7.
Nature communications, Issue 1, Vol. 16, 4090
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Walla B, Maslakova A, Bischoff D, Janowski R, Niessing D, Weuster-Botz D (2025)
Rational Introduction of Electrostatic Interactions at Crystal Contacts to Enhance Protein Crystallization of an Ene Reductase.
Biomolecules, Issue 4, Vol. 15
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Zhou J, Ridderbeek K, Zou P, Naden AB, Gaussmann S, Song F, Falter-Braun P, Kay ER, Sattler M, Cui J (2025)
Modular Nanoparticle Platform for Solution-Phase Optical Sensing of Protein-Protein Interactions.
ACS applied optical materials, Issue 3, Vol. 3, 676-688
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Shekhar A, Di Lucrezia R, Jerye K, Korotkov VS, Harmrolfs K, Rox K, Weich HA, Ghai I, Delhommel F, Becher I, Degenhart C, Fansa E, Unger A, Habenberger P, Klebl B, Lukat P, Schmelz S, Henke S, Borgert S, Lang JC, Sasse F, Diestel R, Richter C, Schneider-Daum N, Hinkelmann B, Niemz J, Lehr CM, Jänsch L, Huehn J, Alm R, Savitski M, Welte T, Hesterkamp T, Sattler M, Winterhalter M, Blankenfeldt W, Medina E, Bilitewski U, Dinkel K, Brönstrup M (2025)
Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections.
Cell host & microbe, Issue 4, Vol. 33, 560-572.e21
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Krüger FP, Östman J, Mervin L, Tetko IV, Engkvist O (2025)
Publishing neural networks in drug discovery might compromise training data privacy.
Journal of cheminformatics, Issue 1, Vol. 17, 38
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Kaeuferle T, Zwermann M, Stoll N, Ferrada-Ernst P, Jablonowski L, Zeidler R, Willier S, Stenger D, Yassin A, Stripecke R, Feuchtinger T (2025)
All-in-one CRISPR/Cas-engineered glucocorticoid-receptor knock-out EBV-gp350-CAR knock-in T cells are potent and resistant to dexamethasone.
Experimental hematology & oncology, Issue 1, Vol. 14, 40
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Mousa N, Varbanov HP, Kaipanchery V, Gabano E, Ravera M, Toropov AA, Charochkina L, Menezes F, Godin G, Tetko IV (2025)
Online OCHEM multi-task model for solubility and lipophilicity prediction of platinum complexes.
Journal of inorganic biochemistry, Vol. 269, 112890
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Oberheide A, van den Oetelaar MCM, Scheele JJA, Borggräfe J, Engelen SFH, Sattler M, Ottmann C, Cossar PJ, Brunsveld L (2025)
Site-specific molecular glues for the 14-3-3/Tau pS214 protein-protein interaction via reversible covalent imine tethering.
RSC medicinal chemistry, Issue 5, Vol. 16, 2190-2201
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Torren-Peraire P, Verhoeven J, Herman D, Ceulemans H, Tetko IV, Wegner JK (2025)
Improving route development using convergent retrosynthesis planning.
Journal of cheminformatics, Issue 1, Vol. 17, 26
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Hartog PBR, Westerlund AM, Tetko IV, Genheden S (2025)
Investigations into the Efficiency of Computer-Aided Synthesis Planning.
Journal of chemical information and modeling, Issue 4, Vol. 65, 1771-1781
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Lenzen B, Rösch F, Legen J, Ruwe H, Kachariya N, Sattler M, Small I, Schmitz-Linneweber C (2025)
The chloroplast RNA-binding protein CP29A supports rbcL expression during cold acclimation.
Proceedings of the National Academy of Sciences of the United States of America, Issue 5, Vol. 122, e2403969122
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Luo J, Molbay M, Chen Y, Horvath I, Kadletz K, Kick B, Zhao S, Al-Maskari R, Singh I, Ali M, Bhatia HS, Minde DP, Negwer M, Hoeher L, Calandra GM, Groschup B, Su J, Kimna C, Rong Z, Galensowske N, Todorov MI, Jeridi D, Ohn TL, Roth S, Simats A, Singh V, Khalin I, Pan C, Arús BA, Bruns OT, Zeidler R, Liesz A, Protzer U, Plesnila N, Ussar S, Hellal F, Paetzold J, Elsner M, Dietz H, Erturk A (2025)
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.
Nature biotechnology
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Van Herck J, Gil MV, Jablonka KM, Abrudan A, Anker AS, Asgari M, Blaiszik B, Buffo A, Choudhury L, Corminboeuf C, Daglar H, Elahi AM, Foster IT, Garcia S, Garvin M, Godin G, Good LL, Gu J, Xiao Hu N, Jin X, Junkers T, Keskin S, Knowles TPJ, Laplaza R, Lessona M, Majumdar S, Mashhadimoslem H, McIntosh RD, Moosavi SM, Mouriño B, Nerli F, Pevida C, Poudineh N, Rajabi-Kochi M, Saar KL, Hooriabad Saboor F, Sagharichiha M, Schmidt KJ, Shi J, Simone E, Svatunek D, Taddei M, Tetko I, Tolnai D, Vahdatifar S, Whitmer J, Wieland DCF, Willumeit-Römer R, Züttel A, Smit B (2025)
Assessment of fine-tuned large language models for real-world chemistry and material science applications.
Chemical science, Issue 2, Vol. 16, 670-684
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Han Z, Xia Z, Xia J, Tetko IV, Wu S (2025)
The state-of-the-art machine learning model for plasma protein binding prediction: Computational modeling with OCHEM and experimental validation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 204, 106946
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Kogut-Günthel MM, Zara Z, Nicoli A, Steuer A, Lopez-Balastegui M, Selent J, Karanth S, Koehler M, Ciancetta A, Abiko LA, Hagn F, Di Pizio A (2025)
The path to the G protein-coupled receptor structural landscape: Major milestones and future directions.
British journal of pharmacology, Issue 14, Vol. 182, 3225-3248
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