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Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation.
Nucleic acids research
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Chin Sang C, Moore G, Tereshchenko M, Zhang H, Nosella ML, Dasovich M, Alderson TR, Leung AKL, Finkelstein IJ, Forman-Kay JD, Lee HO (2024)
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation.
EMBO reports
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Han Z, Xia Z, Xia J, Tetko IV, Wu S (2024)
The state-of-the-art machine learning model for Plasma Protein Binding Prediction: computational modeling with OCHEM and experimental validation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 106946
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Santovito D, Henderson JM, Bidzhekov K, Triantafyllidou V, Jansen Y, Chen Z, Farina FM, Diagel A, Aslani M, Blanchet X, Schunkert H, Megens RTA, Döring Y, Sattler M, Weber C (2024)
Mex3a Protects Against Atherosclerosis: Evidence From Mice and Humans.
Circulation, Issue 15, Vol. 150, 1213-1216
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Kellner M, Hörmann J, Fackler S, Hu Y, Zhou T, Lu L, Ilik I, Aktas T, Feederle R, Hauck SM, Gires O, Gärtner K, Li L, Zeidler R (2024)
The Nuclear Speckles Protein SRRM2 Is Exposed on the Surface of Cancer Cells.
Cells, Issue 18, Vol. 13
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Banasik M, Napolitano V, Blat A, Abdulkarim K, Plewka J, Czaplewski C, Gieldon A, Kozak M, Wladyka B, Popowicz G, Dubin G (2024)
Structural dynamics of the TPR domain of the peroxisomal cargo receptor Pex5 in Trypanosoma.
International journal of biological macromolecules, Issue Pt 4, Vol. 280, 135510
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Freisem D, Rodriguez-Alfonso AA, Lawrenz J, Zhou Z, Monecke T, Preising N, Endres S, Wiese S, Ständker L, Kuan SL, Thal DR, Weil T, Niessing D, Barth H, Kirchhoff F, Harms M, Münch J, Sparrer KMJ (2024)
A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1.
Cellular and molecular life sciences : CMLS, Issue 1, Vol. 81, 409
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Bussi G, Bonomi M, Gkeka P, Sattler M, Al-Hashimi HM, Auffinger P, Duca M, Foricher Y, Incarnato D, Jones AN, Kirmizialtin S, Krepl M, Orozco M, Palermo G, Pasquali S, Salmon L, Schwalbe H, Westhof E, Zacharias M (2024)
RNA dynamics from experimental and computational approaches.
Structure (London, England : 1993), Issue 9, Vol. 32, 1281-1287
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Kogut-Günthel MM, Zara Z, Nicoli A, Steuer A, Lopez-Balastegui M, Selent J, Karanth S, Koehler M, Ciancetta A, Abiko LA, Hagn F, Di Pizio A (2024)
The path to the G protein-coupled receptor structural landscape: Major milestones and future directions.
British journal of pharmacology
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Martínez-Lumbreras S, Morguet C, Sattler M (2024)
Dynamic interactions drive early spliceosome assembly.
Current opinion in structural biology, Vol. 88, 102907
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Hildebrand MS, Braden RO, Lauretta ML, Kaspi A, Leventer RJ, Anderson M, Goel H, Bahlo M, Scheffer IE, Amor DJ, Janowski R, Niessing D, Morgan AT (2024)
Inherited PURA Pathogenic Variant Associated With a Mild Neurodevelopmental Disorder.
Neurology. Genetics, Issue 5, Vol. 10, e200181
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Rodina N, Sarkar R, Tsakalos D, Suladze S, Niu Z, Reif B (2024)
Manual and automatic assignment of two different Aβ40 amyloid fibril polymorphs using MAS solid-state NMR spectroscopy.
Biomolecular NMR assignments, Issue 2, Vol. 18, 201-212
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Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V (2024)
Correction to "The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression".
Nature communications, Issue 1, Vol. 15, 6632
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Preferred inhibition of pro-apoptotic Bak by BclxL via a two-step mechanism.
Cell reports, Issue 8, Vol. 43, 114526
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Lis K, Plewka J, Menezes F, Bielecka E, Chykunova Y, Pustelny K, Niebling S, Garcia AS, Garcia-Alai M, Popowicz GM, Nowak JS, Czarna A, Kantyka T, Pyrc K (2024)
Corrigendum to "SARS-CoV-2 Mpro oligomerization as a potential target for therapy" [Int. J. Biol. Macromol. 267 (Part 1) (May 2024) 131392].
International journal of biological macromolecules, Issue Pt 1, Vol. 276, 133473
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Modulation of Alzheimer's Disease Aβ40 Fibril Polymorphism by the Small Heat Shock Protein αB-Crystallin.
Journal of the American Chemical Society, Issue 28, Vol. 146, 19077-19087
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Light-Induced Transformation of Virus-Like Particles on TiO2.
ACS applied materials & interfaces, Issue 28, Vol. 16, 37275-37287
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Zinc and pH modulate the ability of insulin to inhibit aggregation of islet amyloid polypeptide.
Communications biology, Issue 1, Vol. 7, 776
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Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy.
Journal of controlled release : official journal of the Controlled Release Society, Vol. 372, 522-530
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Aggregation Mechanisms and Molecular Structures of Amyloid-β in Alzheimer's Disease.
Chemistry (Weinheim an der Bergstrasse, Germany), Issue 48, Vol. 30, e202400277
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Atomic resolution structure of full-length human insulin fibrils.
Proceedings of the National Academy of Sciences of the United States of America, Issue 23, Vol. 121, e2401458121
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Efficient Segmental Isotope Labeling of Integral Membrane Proteins for High-Resolution NMR Studies.
Journal of the American Chemical Society, Issue 22, Vol. 146, 15403-15410
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Tetko IV (2024)
Tox24 Challenge.
Chemical research in toxicology, Issue 6, Vol. 37, 825-826
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MISATO: machine learning dataset of protein-ligand complexes for structure-based drug discovery.
Nature computational science, Issue 5, Vol. 4, 367-378
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Suladze S, Sustay Martinez C, Rodriguez Camargo DC, Engler J, Rodina N, Sarkar R, Zacharias M, Reif B (2024)
Structural Insights into Seeding Mechanisms of hIAPP Fibril Formation.
Journal of the American Chemical Society, Issue 20, Vol. 146, 13783-13796
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Legen J, Lenzen B, Kachariya N, Feltgen S, Gao Y, Mergenthal S, Weber W, Klotzsch E, Zoschke R, Sattler M, Schmitz-Linneweber C (2024)
A prion-like domain is required for phase separation and chloroplast RNA processing during cold acclimation in Arabidopsis.
The Plant cell, Issue 8, Vol. 36, 2851-2872
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Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M (2024)
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs.
Nature communications, Issue 1, Vol. 15, 3888
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PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association.
eLife, Vol. 13
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Gaussmann S, Peschel R, Ott J, Zak KM, Sastre J, Delhommel F, Popowicz GM, Boekhoven J, Schliebs W, Erdmann R, Sattler M (2024)
Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif.
Nature communications, Issue 1, Vol. 15, 3317
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Chen YL, Jones AN, Crawford A, Sattler M, Ettinger A, Torres-Padilla ME (2024)
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.
The Journal of cell biology, Issue 7, Vol. 223
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Lis K, Plewka J, Menezes F, Bielecka E, Chykunova Y, Pustelny K, Niebling S, Garcia AS, Garcia-Alai M, Popowicz GM, Czarna A, Kantyka T, Pyrc K (2024)
SARS-CoV-2 Mpro oligomerization as a potential target for therapy.
International journal of biological macromolecules, Issue Pt 1, Vol. 267, 131392
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Hartog PBR, Krüger F, Genheden S, Tetko IV (2024)
Using test-time augmentation to investigate explainable AI: inconsistencies between method, model and human intuition.
Journal of cheminformatics, Issue 1, Vol. 16, 39
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Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor AJ, Couchet M, Ribicic S, Wabitsch M, Messias AC, Iuso A, Müller TD, Rydén M, Mejhert N, Krahmer N (2024)
A spatiotemporal proteomic map of human adipogenesis.
Nature metabolism, Issue 5, Vol. 6, 861-879
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Matsuda A, Plewka J, Rawski M, Mourão A, Zajko W, Siebenmorgen T, Kresik L, Lis K, Jones AN, Pachota M, Karim A, Hartman K, Nirwal S, Sonani R, Chykunova Y, Minia I, Mak P, Landthaler M, Nowotny M, Dubin G, Sattler M, Suder P, Popowicz GM, Pyrć K, Czarna A (2024)
Despite the odds: formation of the SARS-CoV-2 methylation complex.
Nucleic acids research, Issue 11, Vol. 52, 6441-6458
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Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V (2024)
The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
Nature communications, Issue 1, Vol. 15, 2194
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Sturla S, Dai J, Kraegeloh A, Normura D, Tetko I, Wang Y, Serrano J (2024)
Invitation to Apply or Nominate for Membership in the Early Career Board of Chemical Research in Toxicology.
Chemical research in toxicology, Issue 2, Vol. 37, 127-128
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Sang CC, Moore G, Tereshchenko M, Nosella ML, Zhang H, Alderson TR, Dasovich M, Leung A, Finkelstein IJ, Forman-Kay JD, Lee HO (2024)
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation.
bioRxiv : the preprint server for biology
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Hunklinger A, Hartog P, Šícho M, Godin G, Tetko IV (2024)
The openOCHEM consensus model is the best-performing open-source predictive model in the First EUOS/SLAS joint compound solubility challenge.
SLAS discovery : advancing life sciences R & D, Issue 2, Vol. 29, 100144
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Roca-Martínez J, Kang HS, Sattler M, Vranken W (2024)
Analysis of the inter-domain orientation of tandem RRM domains with diverse linkers: connecting experimental with AlphaFold2 predicted models.
NAR genomics and bioinformatics, Issue 1, Vol. 6, lqae002
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Witzenberger M, Janowski R, Niessing D (2024)
Crystal structure of the RNA-recognition motif of Drosophila melanogaster tRNA (uracil-5-)-methyltransferase homolog A.
Acta crystallographica. Section F, Structural biology communications, Issue Pt 2, Vol. 80, 36-42
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Giehler F, Ostertag MS, Sommermann T, Weidl D, Sterz KR, Kutz H, Moosmann A, Feller SM, Geerlof A, Biesinger B, Popowicz GM, Kirchmair J, Kieser A (2024)
Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.
Nature communications, Issue 1, Vol. 15, 414
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Lewinski M, Steffen A, Kachariya N, Elgner M, Schmal C, Messini N, Köster T, Reichel M, Sattler M, Zarnack K, Staiger D (2024)
Arabidopsis thaliana GLYCINE RICH RNA-BINDING PROTEIN 7 interaction with its iCLIP target LHCB1.1 correlates with changes in RNA stability and circadian oscillation.
The Plant journal : for cell and molecular biology, Issue 1, Vol. 118, 203-224
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Voinarovska V, Kabeshov M, Dudenko D, Genheden S, Tetko IV (2024)
When Yield Prediction Does Not Yield Prediction: An Overview of the Current Challenges.
Journal of chemical information and modeling, Issue 1, Vol. 64, 42-56
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