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Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction.
Frontiers in cell and developmental biology, Vol. 9, 737159
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Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, Rutz D, Blair L, Buchner J, Sattler M (2021)
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.
Science advances, Issue 51, Vol. 7, eabl7295
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Olguín-Contreras LF, Mendler AN, Popowicz G, Hu B, Noessner E (2021)
Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy.
Frontiers in immunology, Vol. 12, 750478
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MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells.
PLoS genetics, Issue 12, Vol. 17, e1009951
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Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V (2021)
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Nature immunology, Issue 12, Vol. 22, 1563-1576
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Mühlhofer M, Peters C, Kriehuber T, Kreuzeder M, Kazman P, Rodina N, Reif B, Haslbeck M, Weinkauf S, Buchner J (2021)
Phosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble.
Nature communications, Issue 1, Vol. 12, 6697
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Fottner M, Weyh M, Gaussmann S, Schwarz D, Sattler M, Lang K (2021)
A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes.
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Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite.
Environmental health perspectives, Issue 10, Vol. 129, 109001
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Tošner Z, Brandl MJ, Blahut J, Glaser SJ, Reif B (2021)
Maximizing efficiency of dipolar recoupling in solid-state NMR using optimal control sequences.
Science advances, Issue 42, Vol. 7, eabj5913
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Zhang X, Schuhmachers P, Mourão A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck SM, Hammerschmidt W, Küppers R, Kuster B, Raab M, Strebhardt K, Sattler M, Münz C, Kempkes B (2021)
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.
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Fino R, Lenhart D, Kalel VC, Softley CA, Napolitano V, Byrne R, Schliebs W, Dawidowski M, Erdmann R, Sattler M, Schneider G, Plettenburg O, Popowicz GM (2021)
Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents.
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Sperl LE, Rührnößl F, Schiller A, Haslbeck M, Hagn F (2021)
High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.
The EMBO journal, Issue 20, Vol. 40, e107159
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Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P (2021)
Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold.
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Fukumura K, Yoshimoto R, Sperotto L, Kang HS, Hirose T, Inoue K, Sattler M, Mayeda A (2021)
SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.
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Reyes Romero A, Lunev S, Popowicz GM, Calderone V, Gentili M, Sattler M, Plewka J, Taube M, Kozak M, Holak TA, Dömling ASS, Groves MR (2021)
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
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Reif B, Ashbrook SE, Emsley L, Hong M (2021)
Solid-state NMR spectroscopy.
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Protease resistance of ex vivo amyloid fibrils implies the proteolytic selection of disease-associated fibril morphologies.
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de Souza Degenhardt MF, Vitale PAM, Abiko LA, Zacharias M, Sattler M, Oliveira CLP, Salinas RK (2021)
Molecular insights on CALX-CBD12 interdomain dynamics from MD simulations, RDCs, and SAXS.
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Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite.
Environmental health perspectives, Issue 7, Vol. 129, 79001
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Zak KM, Bostock MJ, Waligorska I, Thøgersen IB, Enghild JJ, Popowicz GM, Grudnik P, Potempa J, Ksiazek M (2021)
Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia.
Journal of enzyme inhibition and medicinal chemistry, Issue 1, Vol. 36, 1267-1281
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Lian X, Xia Z, Li X, Karpov P, Jin H, Tetko IV, Xia J, Wu S (2021)
Anti-MRSA drug discovery by ligand-based virtual screening and biological evaluation.
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Sperl LE, Hagn F (2021)
NMR Structural and Biophysical Analysis of the Disease-Linked Inner Mitochondrial Membrane Protein MPV17.
Journal of molecular biology, Issue 15, Vol. 433, 167098
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Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mourão A, Klepac K, Bühler L, Alfaro AJ, Kaczmarek I, Linford A, Bosma M, Shilkova O, Ritvos O, Nakamura N, Hirose S, Lassi M, Teperino R, Machado J, Scheideler M, Dietrich A, Geerlof A, Feuchtinger A, Blutke A, Fischer K, Müller TD, Kessler K, Schöneberg T, Thor D, Hornemann S, Kruse M, Nawroth P, Pivovarova-Ramich O, Pfeiffer AFH, Sattler M, Blüher M, Herzig S (2021)
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Nature communications, Issue 1, Vol. 12, 2999
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Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U (2021)
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
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Liu N, Gujrati V, Malekzadeh-Najafabadi J, Werner JPF, Klemm U, Tang L, Chen Z, Prakash J, Huang Y, Stiel A, Mettenleiter G, Aichler M, Blutke A, Walch A, Kleigrewe K, Razansky D, Sattler M, Ntziachristos V (2021)
Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors.
Photoacoustics, Vol. 22, 100263
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Gaussmann S, Gopalswamy M, Eberhardt M, Reuter M, Zou P, Schliebs W, Erdmann R, Sattler M (2021)
Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14.
Frontiers in cell and developmental biology, Vol. 9, 651449
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Mansouri K, Karmaus AL, Fitzpatrick J, Patlewicz G, Pradeep P, Alberga D, Alepee N, Allen TEH, Allen D, Alves VM, Andrade CH, Auernhammer TR, Ballabio D, Bell S, Benfenati E, Bhattacharya S, Bastos JV, Boyd S, Brown JB, Capuzzi SJ, Chushak Y, Ciallella H, Clark AM, Consonni V, Daga PR, Ekins S, Farag S, Fedorov M, Fourches D, Gadaleta D, Gao F, Gearhart JM, Goh G, Goodman JM, Grisoni F, Grulke CM, Hartung T, Hirn M, Karpov P, Korotcov A, Lavado GJ, Lawless M, Li X, Luechtefeld T, Lunghini F, Mangiatordi GF, Marcou G, Marsh D, Martin T, Mauri A, Muratov EN, Myatt GJ, Nguyen DT, Nicolotti O, Note R, Pande P, Parks AK, Peryea T, Polash AH, Rallo R, Roncaglioni A, Rowlands C, Ruiz P, Russo DP, Sayed A, Sayre R, Sheils T, Siegel C, Silva AC, Simeonov A, Sosnin S, Southall N, Strickland J, Tang Y, Teppen B, Tetko IV, Thomas D, Tkachenko V, Todeschini R, Toma C, Tripodi I, Trisciuzzi D, Tropsha A, Varnek A, Vukovic K, Wang Z, Wang L, Waters KM, Wedlake AJ, Wijeyesakere SJ, Wilson D, Xiao Z, Yang H, Zahoranszky-Kohalmi G, Zakharov AV, Zhang FF, Zhang Z, Zhao T, Zhu H, Zorn KM, Casey W, Kleinstreuer NC (2021)
CATMoS: Collaborative Acute Toxicity Modeling Suite.
Environmental health perspectives, Issue 4, Vol. 129, 47013
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Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A (2021)
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Journal of medicinal chemistry, Issue 8, Vol. 64, 4623-4661
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Munshaw S, Bruche S, Redpath AN, Jones A, Patel J, Dubé KN, Lee R, Hester SS, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon KM, Smart N (2021)
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
The Journal of clinical investigation, Issue 10, Vol. 131, e127884
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Molitor L, Bacher S, Burczyk S, Niessing D (2021)
The Molecular Function of PURA and Its Implications in Neurological Diseases.
Frontiers in genetics, Vol. 12, 638217
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Liu N, O'Connor P, Gujrati V, Gorpas D, Glasl S, Blutke A, Walch A, Kleigrewe K, Sattler M, Plettenburg O, Ntziachristos V (2021)
Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.
Advanced healthcare materials, Issue 9, Vol. 10, e2002115
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Li G, Chen TW, Nickel AC, Muhammad S, Steiger HJ, Tzaridis T, Hänggi D, Zeidler R, Zhang W, Kahlert UD (2021)
Carbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor Cells.
OncoTargets and therapy, Vol. 14, 1707-1718
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Naarmann-de Vries IS, Senatore R, Moritz B, Marx G, Urlaub H, Niessing D, Ostareck DH, Ostareck-Lederer A (2021)
Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis.
Nucleic acids research, Issue 6, Vol. 49, 3507-3523
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Alderson TR, Adriaenssens E, Asselbergh B, Pritišanac I, Van Lent J, Gastall HY, Wälti MA, Louis JM, Timmerman V, Baldwin AJ, Lp Benesch J (2021)
A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.
The EMBO journal, Issue 8, Vol. 40, e103811
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Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML, Wagner G (2021)
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nature structural & molecular biology, Issue 3, Vol. 28, 258-267
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Schuch LA, Forstner M, Rapp CK, Li Y, Smith DEC, Mendes MI, Delhommel F, Sattler M, Emiralioğlu N, Taskiran EZ, Orhan D, Kiper N, Rohlfs M, Jeske T, Hastreiter M, Gerstlauer M, Torrent-Vernetta A, Moreno-Galdó A, Kammer B, Brasch F, Reu-Hofer S, Griese M (2021)
FARS1-related disorders caused by bi-allelic mutations in cytosolic phenylalanyl-tRNA synthetase genes: Look beyond the lungs!
Clinical genetics, Issue 6, Vol. 99, 789-801
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Kleinstreuer NC, Tetko IV, Tong W (2021)
Introduction to Special Issue: Computational Toxicology.
Chemical research in toxicology, Issue 2, Vol. 34, 171-175
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Biebl MM, Lopez A, Rehn A, Freiburger L, Lawatscheck J, Blank B, Sattler M, Buchner J (2021)
Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.
Nature communications, Issue 1, Vol. 12, 828
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Alderson TR, Kay LE (2021)
NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function.
Cell, Issue 3, Vol. 184, 577-595
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Wu L, Huang R, Tetko IV, Xia Z, Xu J, Tong W (2021)
Trade-off Predictivity and Explainability for Machine-Learning Powered Predictive Toxicology: An in-Depth Investigation with Tox21 Data Sets.
Chemical research in toxicology, Issue 2, Vol. 34, 541-549
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Reuter M, Kooshapur H, Suda JG, Gaussmann S, Neuhaus A, Brühl L, Bharti P, Jung M, Schliebs W, Sattler M, Erdmann R (2021)
Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
Journal of molecular biology, Issue 5, Vol. 433, 166765
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Semenyuta IV, Trush MM, Kovalishyn VV, Rogalsky SP, Hodyna DM, Karpov P, Xia Z, Tetko IV, Metelytsia LO (2021)
Structure-Activity Relationship Modeling and Experimental Validation of the Imidazolium and Pyridinium Based Ionic Liquids as Potential Antibacterials of MDR Acinetobacter Baumannii and Staphylococcus Aureus.
International journal of molecular sciences, Issue 2, Vol. 22
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Savitskiy S, Wachtel R, Pourjafar-Dehkordi D, Kang HS, Trauschke V, Lamb DC, Sattler M, Zacharias M, Itzen A (2021)
Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation.
iScience, Issue 1, Vol. 24, 101940
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Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA (2021)
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Nature chemical biology, Issue 3, Vol. 17, 272-279
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López A, Elimelech AR, Klimm K, Sattler M (2021)
The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90.
Chembiochem : a European journal of chemical biology, Issue 6, Vol. 22, 1084-1092
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Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P (2021)
Albumin-binding domain extends half-life of glucagon-like peptide-1.
European journal of pharmacology, Vol. 890, 173650
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Pradhan T, Annamalai K, Sarkar R, Hegenbart U, Schönland S, Fändrich M, Reif B (2021)
Solid state NMR assignments of a human λ-III immunoglobulin light chain amyloid fibril.
Biomolecular NMR assignments, Issue 1, Vol. 15, 9-16
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Goba I, Goricanec D, Schum D, Hillenbrand M, Plückthun A, Hagn F (2021)
Probing the Conformation States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling.
Chembiochem : a European journal of chemical biology, Issue 1, Vol. 22, 139-146
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