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Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation.
Nucleic acids research
DOI: 10.1093/nar/gkae1107, PubMed: 39558160

Santovito D, Henderson JM, Bidzhekov K, Triantafyllidou V, Jansen Y, Chen Z, Farina FM, Diagel A, Aslani M, Blanchet X, Schunkert H, Megens RTA, Döring Y, Sattler M, Weber C (2024)
Mex3a Protects Against Atherosclerosis: Evidence From Mice and Humans.
Circulation, Issue 15, Vol. 150, 1213-1216
DOI: 10.1161/CIRCULATIONAHA.124.069526, PubMed: 39374329

Bussi G, Bonomi M, Gkeka P, Sattler M, Al-Hashimi HM, Auffinger P, Duca M, Foricher Y, Incarnato D, Jones AN, Kirmizialtin S, Krepl M, Orozco M, Palermo G, Pasquali S, Salmon L, Schwalbe H, Westhof E, Zacharias M (2024)
RNA dynamics from experimental and computational approaches.
Structure (London, England : 1993), Issue 9, Vol. 32, 1281-1287
DOI: 10.1016/j.str.2024.07.019, PubMed: 39241758

Martínez-Lumbreras S, Morguet C, Sattler M (2024)
Dynamic interactions drive early spliceosome assembly.
Current opinion in structural biology, Vol. 88, 102907
DOI: 10.1016/j.sbi.2024.102907, PubMed: 39168044

Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V (2024)
Correction to "The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression".
Nature communications, Issue 1, Vol. 15, 6632
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Liu N, O'Connor P, Gujrati V, Shelar D, Ma X, Anzenhofer P, Klemm U, Su X, Huang Y, Kleigrewe K, Feuchtinger A, Walch A, Sattler M, Plettenburg O, Ntziachristos V (2024)
Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy.
Journal of controlled release : official journal of the Controlled Release Society, Vol. 372, 522-530
DOI: 10.1016/j.jconrel.2024.06.037, PubMed: 38897293

Siebenmorgen T, Menezes F, Benassou S, Merdivan E, Didi K, Mourão ASD, Kitel R, Liò P, Kesselheim S, Piraud M, Theis FJ, Sattler M, Popowicz GM (2024)
MISATO: machine learning dataset of protein-ligand complexes for structure-based drug discovery.
Nature computational science, Issue 5, Vol. 4, 367-378
DOI: 10.1038/s43588-024-00627-2, PubMed: 38730184

Legen J, Lenzen B, Kachariya N, Feltgen S, Gao Y, Mergenthal S, Weber W, Klotzsch E, Zoschke R, Sattler M, Schmitz-Linneweber C (2024)
A prion-like domain is required for phase separation and chloroplast RNA processing during cold acclimation in Arabidopsis.
The Plant cell, Issue 8, Vol. 36, 2851-2872
DOI: 10.1093/plcell/koae145, PubMed: 38723165

Martínez-Lumbreras S, Träger LK, Mulorz MM, Payr M, Dikaya V, Hipp C, König J, Sattler M (2024)
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs.
Nature communications, Issue 1, Vol. 15, 3888
DOI: 10.1038/s41467-024-48004-x, PubMed: 38719828

Proske M, Janowski R, Bacher S, Kang HS, Monecke T, Koehler T, Hutten S, Tretter J, Crois A, Molitor L, Varela-Rial A, Fino R, Donati E, De Fabritiis G, Dormann D, Sattler M, Niessing D (2024)
PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association.
eLife, Vol. 13
DOI: 10.7554/eLife.93561, PubMed: 38655849

Gaussmann S, Peschel R, Ott J, Zak KM, Sastre J, Delhommel F, Popowicz GM, Boekhoven J, Schliebs W, Erdmann R, Sattler M (2024)
Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif.
Nature communications, Issue 1, Vol. 15, 3317
DOI: 10.1038/s41467-024-47605-w, PubMed: 38632234

Chen YL, Jones AN, Crawford A, Sattler M, Ettinger A, Torres-Padilla ME (2024)
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.
The Journal of cell biology, Issue 7, Vol. 223
DOI: 10.1083/jcb.202309027, PubMed: 38625077

Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor AJ, Couchet M, Ribicic S, Wabitsch M, Messias AC, Iuso A, Müller TD, Rydén M, Mejhert N, Krahmer N (2024)
A spatiotemporal proteomic map of human adipogenesis.
Nature metabolism, Issue 5, Vol. 6, 861-879
DOI: 10.1038/s42255-024-01025-8, PubMed: 38565923

Matsuda A, Plewka J, Rawski M, Mourão A, Zajko W, Siebenmorgen T, Kresik L, Lis K, Jones AN, Pachota M, Karim A, Hartman K, Nirwal S, Sonani R, Chykunova Y, Minia I, Mak P, Landthaler M, Nowotny M, Dubin G, Sattler M, Suder P, Popowicz GM, Pyrć K, Czarna A (2024)
Despite the odds: formation of the SARS-CoV-2 methylation complex.
Nucleic acids research, Issue 11, Vol. 52, 6441-6458
DOI: 10.1093/nar/gkae165, PubMed: 38499483

Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V (2024)
The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
Nature communications, Issue 1, Vol. 15, 2194
DOI: 10.1038/s41467-024-46371-z, PubMed: 38467629

Roca-Martínez J, Kang HS, Sattler M, Vranken W (2024)
Analysis of the inter-domain orientation of tandem RRM domains with diverse linkers: connecting experimental with AlphaFold2 predicted models.
NAR genomics and bioinformatics, Issue 1, Vol. 6, lqae002
DOI: 10.1093/nargab/lqae002, PubMed: 38288375

Lewinski M, Steffen A, Kachariya N, Elgner M, Schmal C, Messini N, Köster T, Reichel M, Sattler M, Zarnack K, Staiger D (2024)
Arabidopsis thaliana GLYCINE RICH RNA-BINDING PROTEIN 7 interaction with its iCLIP target LHCB1.1 correlates with changes in RNA stability and circadian oscillation.
The Plant journal : for cell and molecular biology, Issue 1, Vol. 118, 203-224
DOI: 10.1111/tpj.16601, PubMed: 38124335

Aretz J, Aziz M, Strohmeyer N, Sattler M, Fässler R (2023)
Talin and kindlin use integrin tail allostery and direct binding to activate integrins.
Nature structural & molecular biology, Issue 12, Vol. 30, 1913-1924
DOI: 10.1038/s41594-023-01139-9, PubMed: 38087085

Fukumura K, Sperotto L, Seuß S, Kang HS, Yoshimoto R, Sattler M, Mayeda A (2023)
SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset of human short introns.
Cell reports, Issue 12, Vol. 42, 113534
DOI: 10.1016/j.celrep.2023.113534, PubMed: 38065098

Higuera-Rodriguez RA, De Pascali MC, Aziz M, Sattler M, Rant U, Kaiser W (2023)
Kinetic FRET Assay to Measure Binding-Induced Conformational Changes of Nucleic Acids.
ACS sensors, Issue 12, Vol. 8, 4597-4606
DOI: 10.1021/acssensors.3c01527, PubMed: 38060303

Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M (2023)
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.
Nature structural & molecular biology, Issue 11, Vol. 30, 1806-1815
DOI: 10.1038/s41594-023-01136-y, PubMed: 37957306

Aschenbrenner I, Siebenmorgen T, Lopez A, Parr M, Ruckgaber P, Kerle A, Rührnößl F, Catici D, Haslbeck M, Frishman D, Sattler M, Zacharias M, Feige MJ (2023)
Assembly-dependent Structure Formation Shapes Human Interleukin-23 versus Interleukin-12 Secretion.
Journal of molecular biology, Issue 23, Vol. 435, 168300
DOI: 10.1016/j.jmb.2023.168300, PubMed: 37805067

Enders L, Siklos M, Borggräfe J, Gaussmann S, Koren A, Malik M, Tomek T, Schuster M, Reiniš J, Hahn E, Rukavina A, Reicher A, Casteels T, Bock C, Winter GE, Hannich JT, Sattler M, Kubicek S (2023)
Pharmacological perturbation of the phase-separating protein SMNDC1.
Nature communications, Issue 1, Vol. 14, 4504
DOI: 10.1038/s41467-023-40124-0, PubMed: 37587144

Ebersberger S, Hipp C, Mulorz MM, Buchbender A, Hubrich D, Kang HS, Martínez-Lumbreras S, Kristofori P, Sutandy FXR, Llacsahuanga Allcca L, Schönfeld J, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K, Sattler M, König J (2023)
FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns.
Molecular cell, Issue 15, Vol. 83, 2653-2672.e15
DOI: 10.1016/j.molcel.2023.07.002, PubMed: 37506698

Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M (2023)
Structural basis for specific RNA recognition by the alternative splicing factor RBM5.
Nature communications, Issue 1, Vol. 14, 4233
DOI: 10.1038/s41467-023-39961-w, PubMed: 37454201

Marciniak M, Mróz P, Napolitano V, Kalel VC, Fino R, Pykacz E, Schliebs W, Plettenburg O, Erdmann R, Sattler M, Popowicz GM, Dawidowski M (2023)
Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template.
European journal of medicinal chemistry, Vol. 258, 115587
DOI: 10.1016/j.ejmech.2023.115587, PubMed: 37406382

Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M (2023)
Phase separation of FSP1 promotes ferroptosis.
Nature, Issue 7969, Vol. 619, 371-377
DOI: 10.1038/s41586-023-06255-6, PubMed: 37380771

Calonaci N, Bernetti M, Jones A, Sattler M, Bussi G (2023)
Molecular Dynamics Simulations with Grand-Canonical Reweighting Suggest Cooperativity Effects in RNA Structure Probing Experiments.
Journal of chemical theory and computation, Issue 12, Vol. 19, 3672-3685
DOI: 10.1021/acs.jctc.3c00084, PubMed: 37288967

Svilenov HL, Delhommel F, Siebenmorgen T, Rührnößl F, Popowicz GM, Reiter A, Sattler M, Brockmeyer C, Buchner J (2023)
Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2.
Communications biology, Issue 1, Vol. 6, 386
DOI: 10.1038/s42003-023-04762-w, PubMed: 37031320

Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T (2023)
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins.
Nature methods, Issue 4, Vol. 20, 523-535
DOI: 10.1038/s41592-023-01807-0, PubMed: 36973549

Weller M, Sattler M, Rant U (2023)
Development of an aptamer-based screening for identification and characterization of novel RNA therapeutics using switchSENSE® technology.
Biophysical journal, Issue 3S1, Vol. 122, 357a
DOI: 10.1016/j.bpj.2022.11.1974, PubMed: 36783808

Roca-Martínez J, Dhondge H, Sattler M, Vranken WF (2023)
Deciphering the RRM-RNA recognition code: A computational analysis.
PLoS computational biology, Issue 1, Vol. 19, e1010859
DOI: 10.1371/journal.pcbi.1010859, PubMed: 36689472

Zanuttigh E, Derderian K, Güra MA, Geerlof A, Di Meo I, Cavestro C, Hempfling S, Ortiz-Collazos S, Mauthe M, Kmieć T, Cammarota E, Panzeri MC, Klopstock T, Sattler M, Winkelmann J, Messias AC, Iuso A (2023)
Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro.
Pharmaceutics, Issue 1, Vol. 15
DOI: 10.3390/pharmaceutics15010267, PubMed: 36678896

Delhommel F, Martínez-Lumbreras S, Sattler M (2023)
Combining NMR, SAXS and SANS to characterize the structure and dynamics of protein complexes.
Methods in enzymology, Vol. 678, 263-297
DOI: 10.1016/bs.mie.2022.09.020, PubMed: 36641211

Keil P, Wulf A, Kachariya N, Reuscher S, Hühn K, Silbern I, Altmüller J, Keller M, Stehle R, Zarnack K, Sattler M, Urlaub H, Sträßer K (2023)
Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA.
Nucleic acids research, Issue 2, Vol. 51, 831-851
DOI: 10.1093/nar/gkac1206, PubMed: 36583366

Chora AF, Pedroso D, Kyriakou E, Pejanovic N, Colaço H, Gozzelino R, Barros A, Willmann K, Velho T, Moita CF, Santos I, Pereira P, Carvalho S, Martins FB, Ferreira JA, de Almeida SF, Benes V, Anrather J, Weis S, Soares MP, Geerlof A, Neefjes J, Sattler M, Messias AC, Neves-Costa A, Moita LF (2022)
DNA damage independent inhibition of NF-κB transcription by anthracyclines.
eLife, Vol. 11
DOI: 10.7554/eLife.77443, PubMed: 36476511

Gopalswamy M, Zheng C, Gaussmann S, Kooshapur H, Hambruch E, Schliebs W, Erdmann R, Antes I, Sattler M (2023)
Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14.
Biological chemistry, Issue 2-3, Vol. 404, 179-194
DOI: 10.1515/hsz-2022-0177, PubMed: 36437542

Narayanan D, Tran KT, Pallesen JS, Solbak SMØ, Qin Y, Mukminova E, Luchini M, Vasilyeva KO, González Chichón D, Goutsiou G, Poulsen C, Haapanen N, Popowicz GM, Sattler M, Olagnier D, Gajhede M, Bach A (2022)
Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Journal of medicinal chemistry, Issue 21, Vol. 65, 14481-14526
DOI: 10.1021/acs.jmedchem.2c00830, PubMed: 36263945

Napolitano V, Mróz P, Marciniak M, Kalel VC, Softley CA, Janna Olmos JD, Tippler BG, Schorpp K, Rioton S, Fröhlich T, Plettenburg O, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dawidowski M, Dubin G (2022)
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
European journal of medicinal chemistry, Vol. 243, 114778
DOI: 10.1016/j.ejmech.2022.114778, PubMed: 36194937

Napolitano V, Softley CA, Blat A, Kalel VC, Schorpp K, Siebenmorgen T, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dubin G (2022)
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.
Scientific reports, Issue 1, Vol. 12, 14705
DOI: 10.1038/s41598-022-18841-1, PubMed: 36038611

Jones AN, Graß C, Meininger I, Geerlof A, Klostermann M, Zarnack K, Krappmann D, Sattler M (2022)
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1.
Science advances, Issue 31, Vol. 8, eabp9153
DOI: 10.1126/sciadv.abp9153, PubMed: 35921415

Nguyen A, Gemmecker G, Softley CA, Movsisyan LD, Pfaffeneder T, Heine A, Reuter K, Diederich F, Sattler M, Klebe G (2022)
¹⁹F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.
ACS chemical biology, Issue 7, Vol. 17, 1745-1755
DOI: 10.1021/acschembio.2c00080, PubMed: 35763700

Jones AN, Walbrun A, Falleroni F, Rief M, Sattler M (2022)
Conformational Effects of a Cancer-Linked Mutation in Pri-miR-30c RNA.
Journal of molecular biology, Issue 18, Vol. 434, 167705
DOI: 10.1016/j.jmb.2022.167705, PubMed: 35760371

Jones AN, Mourão A, Czarna A, Matsuda A, Fino R, Pyrc K, Sattler M, Popowicz GM (2022)
Characterization of SARS-CoV-2 replication complex elongation and proofreading activity.
Scientific reports, Issue 1, Vol. 12, 9593
DOI: 10.1038/s41598-022-13380-1, PubMed: 35688849

Jussupow A, Lopez A, Baumgart M, Mader SL, Sattler M, Kaila VRI (2022)
Extended conformational states dominate the Hsp90 chaperone dynamics.
The Journal of biological chemistry, Issue 7, Vol. 298, 102101
DOI: 10.1016/j.jbc.2022.102101, PubMed: 35667441

Jones AN, Tikhaia E, Mourão A, Sattler M (2022)
Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1.
Nucleic acids research, Issue 4, Vol. 50, 2350-2362
DOI: 10.1093/nar/gkac080, PubMed: 35166835

Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, Kampmann M, Lamb DC, Rosenzweig R, Sattler M, Buchner J (2022)
NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.
Molecular cell, Issue 3, Vol. 82, 555-569.e7
DOI: 10.1016/j.molcel.2021.12.031, PubMed: 35063133

Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hölscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Slysz K, Szczepanski A, Greve-Isdahl Mohn K, Blomberg B, Sattler M, Hadian K, Popowicz GM, Pyrc K (2022)
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
Cell chemical biology, Issue 5, Vol. 29, 774-784.e8
DOI: 10.1016/j.chembiol.2021.11.006, PubMed: 35021060

Li M, Gaussmann S, Tippler B, Ott J, Popowicz GM, Schliebs W, Sattler M, Erdmann R, Kalel VC (2021)
Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction.
Frontiers in cell and developmental biology, Vol. 9, 737159
DOI: 10.3389/fcell.2021.737159, PubMed: 34988071

Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, Rutz D, Blair L, Buchner J, Sattler M (2021)
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.
Science advances, Issue 51, Vol. 7, eabl7295
DOI: 10.1126/sciadv.abl7295, PubMed: 34919431

Bernaudat F, Gustems M, Günther J, Oliva MF, Buschle A, Göbel C, Pagniez P, Lupo J, Signor L, Müller CW, Morand P, Sattler M, Hammerschmidt W, Petosa C (2022)
Structural basis of DNA methylation-dependent site selectivity of the Epstein-Barr virus lytic switch protein ZEBRA/Zta/BZLF1.
Nucleic acids research, Issue 1, Vol. 50, 490-511
DOI: 10.1093/nar/gkab1183, PubMed: 34893887

Heumüller AW, Jones AN, Mourão A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly-Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jaé N, Sattler M, Dimmeler S (2022)
Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses.
Circulation research, Issue 1, Vol. 130, 67-79
DOI: 10.1161/CIRCRESAHA.121.320029, PubMed: 34789007

Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, Sattler M, Prabu JR, Sidhu SS, Schulman BA (2022)
Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases.
Journal of molecular biology, Issue 2, Vol. 434, 167347
DOI: 10.1016/j.jmb.2021.167347, PubMed: 34767800

Fottner M, Weyh M, Gaussmann S, Schwarz D, Sattler M, Lang K (2021)
A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes.
Nature communications, Issue 1, Vol. 12, 6515
DOI: 10.1038/s41467-021-26812-9, PubMed: 34764289

Ghosh D, Koch U, Hadian K, Sattler M, Tetko IV (2022)
Highly Accurate Filters to Flag Frequent Hitters in AlphaScreen Assays by Suggesting their Mechanism.
Molecular informatics, Issue 3, Vol. 41, e2100151
DOI: 10.1002/minf.202100151, PubMed: 34676998

Zhang X, Schuhmachers P, Mourão A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck SM, Hammerschmidt W, Küppers R, Kuster B, Raab M, Strebhardt K, Sattler M, Münz C, Kempkes B (2021)
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.
EMBO reports, Issue 12, Vol. 22, e53007
DOI: 10.15252/embr.202153007, PubMed: 34605140

Fino R, Lenhart D, Kalel VC, Softley CA, Napolitano V, Byrne R, Schliebs W, Dawidowski M, Erdmann R, Sattler M, Schneider G, Plettenburg O, Popowicz GM (2021)
Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents.
Journal of chemical information and modeling, Issue 10, Vol. 61, 5256-5268
DOI: 10.1021/acs.jcim.1c00472, PubMed: 34597510

Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P (2021)
Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold.
International journal of pharmaceutics, Vol. 607, 121043
DOI: 10.1016/j.ijpharm.2021.121043, PubMed: 34450223

Fukumura K, Yoshimoto R, Sperotto L, Kang HS, Hirose T, Inoue K, Sattler M, Mayeda A (2021)
SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.
Nature communications, Issue 1, Vol. 12, 4910
DOI: 10.1038/s41467-021-24879-y, PubMed: 34389706

Reyes Romero A, Lunev S, Popowicz GM, Calderone V, Gentili M, Sattler M, Plewka J, Taube M, Kozak M, Holak TA, Dömling ASS, Groves MR (2021)
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
Communications biology, Issue 1, Vol. 4, 949
DOI: 10.1038/s42003-021-02442-1, PubMed: 34376783

de Souza Degenhardt MF, Vitale PAM, Abiko LA, Zacharias M, Sattler M, Oliveira CLP, Salinas RK (2021)
Molecular insights on CALX-CBD12 interdomain dynamics from MD simulations, RDCs, and SAXS.
Biophysical journal, Issue 17, Vol. 120, 3664-3675
DOI: 10.1016/j.bpj.2021.07.022, PubMed: 34310942

Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mourão A, Klepac K, Bühler L, Alfaro AJ, Kaczmarek I, Linford A, Bosma M, Shilkova O, Ritvos O, Nakamura N, Hirose S, Lassi M, Teperino R, Machado J, Scheideler M, Dietrich A, Geerlof A, Feuchtinger A, Blutke A, Fischer K, Müller TD, Kessler K, Schöneberg T, Thor D, Hornemann S, Kruse M, Nawroth P, Pivovarova-Ramich O, Pfeiffer AFH, Sattler M, Blüher M, Herzig S (2021)
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Nature communications, Issue 1, Vol. 12, 2999
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Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U (2021)
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
EMBO reports, Issue 6, Vol. 22, e49568
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Liu N, Gujrati V, Malekzadeh-Najafabadi J, Werner JPF, Klemm U, Tang L, Chen Z, Prakash J, Huang Y, Stiel A, Mettenleiter G, Aichler M, Blutke A, Walch A, Kleigrewe K, Razansky D, Sattler M, Ntziachristos V (2021)
Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors.
Photoacoustics, Vol. 22, 100263
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Gaussmann S, Gopalswamy M, Eberhardt M, Reuter M, Zou P, Schliebs W, Erdmann R, Sattler M (2021)
Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14.
Frontiers in cell and developmental biology, Vol. 9, 651449
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Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A (2021)
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Journal of medicinal chemistry, Issue 8, Vol. 64, 4623-4661
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Munshaw S, Bruche S, Redpath AN, Jones A, Patel J, Dubé KN, Lee R, Hester SS, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon KM, Smart N (2021)
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
The Journal of clinical investigation, Issue 10, Vol. 131, e127884
DOI: 10.1172/JCI127884, PubMed: 33784254

Liu N, O'Connor P, Gujrati V, Gorpas D, Glasl S, Blutke A, Walch A, Kleigrewe K, Sattler M, Plettenburg O, Ntziachristos V (2021)
Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.
Advanced healthcare materials, Issue 9, Vol. 10, e2002115
DOI: 10.1002/adhm.202002115, PubMed: 33738974

Schuch LA, Forstner M, Rapp CK, Li Y, Smith DEC, Mendes MI, Delhommel F, Sattler M, Emiralioğlu N, Taskiran EZ, Orhan D, Kiper N, Rohlfs M, Jeske T, Hastreiter M, Gerstlauer M, Torrent-Vernetta A, Moreno-Galdó A, Kammer B, Brasch F, Reu-Hofer S, Griese M (2021)
FARS1-related disorders caused by bi-allelic mutations in cytosolic phenylalanyl-tRNA synthetase genes: Look beyond the lungs!
Clinical genetics, Issue 6, Vol. 99, 789-801
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Calonaci N, Jones A, Cuturello F, Sattler M, Bussi G (2020)
Machine learning a model for RNA structure prediction.
NAR genomics and bioinformatics, Issue 4, Vol. 2, lqaa090
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Biebl MM, Lopez A, Rehn A, Freiburger L, Lawatscheck J, Blank B, Sattler M, Buchner J (2021)
Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.
Nature communications, Issue 1, Vol. 12, 828
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Kang HS, Sattler M (2018)
Capturing dynamic conformational shifts in protein-ligand recognition using integrative structural biology in solution.
Emerging topics in life sciences, Issue 1, Vol. 2, 107-119
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Reuter M, Kooshapur H, Suda JG, Gaussmann S, Neuhaus A, Brühl L, Bharti P, Jung M, Schliebs W, Sattler M, Erdmann R (2021)
Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
Journal of molecular biology, Issue 5, Vol. 433, 166765
DOI: 10.1016/j.jmb.2020.166765, PubMed: 33484719

Savitskiy S, Wachtel R, Pourjafar-Dehkordi D, Kang HS, Trauschke V, Lamb DC, Sattler M, Zacharias M, Itzen A (2021)
Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation.
iScience, Issue 1, Vol. 24, 101940
DOI: 10.1016/j.isci.2020.101940, PubMed: 33426511

Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA (2021)
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Nature chemical biology, Issue 3, Vol. 17, 272-279
DOI: 10.1038/s41589-020-00696-0, PubMed: 33288957

Jagtap PKA, Kubelka T, Soni K, Will CL, Garg D, Sippel C, Kapp TG, Potukuchi HK, Schorpp K, Hadian K, Kessler H, Lührmann R, Hausch F, Bach T, Sattler M (2020)
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
Nature communications, Issue 1, Vol. 11, 5621
DOI: 10.1038/s41467-020-19514-1, PubMed: 33159082

López A, Elimelech AR, Klimm K, Sattler M (2021)
The Charged Linker Modulates the Conformations and Molecular Interactions of Hsp90.
Chembiochem : a European journal of chemical biology, Issue 6, Vol. 22, 1084-1092
DOI: 10.1002/cbic.202000699, PubMed: 33147371

Donau C, Späth F, Sosson M, Kriebisch BAK, Schnitter F, Tena-Solsona M, Kang HS, Salibi E, Sattler M, Mutschler H, Boekhoven J (2020)
Active coacervate droplets as a model for membraneless organelles and protocells.
Nature communications, Issue 1, Vol. 11, 5167
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Jussupow A, Messias AC, Stehle R, Geerlof A, Solbak SMØ, Paissoni C, Bach A, Sattler M, Camilloni C (2020)
The dynamics of linear polyubiquitin.
Science advances, Issue 42, Vol. 6
DOI: 10.1126/sciadv.abc3786, PubMed: 33055165

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, Hundelshausen PV, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020)
Autophagy unleashes noncanonical microRNA functions.
Autophagy, Issue 12, Vol. 16, 2294-2296
DOI: 10.1080/15548627.2020.1830523, PubMed: 33054575

Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou P (2021)
Albumin-binding domain extends half-life of glucagon-like peptide-1.
European journal of pharmacology, Vol. 890, 173650
DOI: 10.1016/j.ejphar.2020.173650, PubMed: 33049303

Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J (2020)
DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.
Molecular cell, Issue 1, Vol. 80, 102-113.e6
DOI: 10.1016/j.molcel.2020.08.003, PubMed: 32853547

Delhommel F, Sattler M (2020)
When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats.
Structure (London, England : 1993), Issue 7, Vol. 28, 730-732
DOI: 10.1016/j.str.2020.06.005, PubMed: 32640252

Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM (2020)
Correction for Softley et al., "Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase".
Antimicrobial agents and chemotherapy, Issue 7, Vol. 64
DOI: 10.1128/AAC.01077-20, PubMed: 32576598

Softley CA, Bostock MJ, Popowicz GM, Sattler M (2020)
Paramagnetic NMR in drug discovery.
Journal of biomolecular NMR, Issue 6-7, Vol. 74, 287-309
DOI: 10.1007/s10858-020-00322-0, PubMed: 32524233

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020)
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis.
Science translational medicine, Issue 546, Vol. 12
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Soni K, Martínez-Lumbreras S, Sattler M (2020)
Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5.
Journal of molecular biology, Issue 14, Vol. 432, 4127-4138
DOI: 10.1016/j.jmb.2020.05.012, PubMed: 32450081

Su W, Tan H, Janowski R, Zhang W, Wang P, Zhang J, Zhai H, Li J, Niessing D, Sattler M, Zou P (2020)
Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics.
Molecular pharmaceutics, Issue 5, Vol. 17, 1663-1673
DOI: 10.1021/acs.molpharmaceut.0c00098, PubMed: 32243177

Vieweg S, Mulholland K, Bräuning B, Kachariya N, Lai YC, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK (2020)
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
The Biochemical journal, Issue 9, Vol. 477, 1651-1668
DOI: 10.1042/BCJ20190664, PubMed: 32227113

Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM (2020)
Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase.
Antimicrobial agents and chemotherapy, Issue 6, Vol. 64, e00123-20
DOI: 10.1128/AAC.00123-20, PubMed: 32205343

Delhommel F, Gabel F, Sattler M (2020)
Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes.
Journal of molecular biology, Issue 9, Vol. 432, 2890-2912
DOI: 10.1016/j.jmb.2020.03.014, PubMed: 32199983

Ratkova EL, Dawidowski M, Napolitano V, Dubin G, Fino R, Ostertag MS, Sattler M, Popowicz G, Tetko IV (2020)
Water envelope has a critical impact on the design of protein-protein interaction inhibitors.
Chemical communications (Cambridge, England), Issue 31, Vol. 56, 4360-4363
DOI: 10.1039/c9cc07714f, PubMed: 32195483

Kang HS, Sánchez-Rico C, Ebersberger S, Sutandy FXR, Busch A, Welte T, Stehle R, Hipp C, Schulz L, Buchbender A, Zarnack K, König J, Sattler M (2020)
An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2.
Proceedings of the National Academy of Sciences of the United States of America, Issue 13, Vol. 117, 7140-7149
DOI: 10.1073/pnas.1913483117, PubMed: 32188783

Mader SL, Lopez A, Lawatscheck J, Luo Q, Rutz DA, Gamiz-Hernandez AP, Sattler M, Buchner J, Kaila VRI (2020)
Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90.
Nature communications, Issue 1, Vol. 11, 1410
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De Angelis M, Schriever SC, Kyriakou E, Sattler M, Messias AC, Schramm KW, Pfluger PT (2020)
Detection and quantification of the anti-obesity drug celastrol in murine liver and brain.
Neurochemistry international, Vol. 136, 104713
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Barthelmes K, Ramcke E, Kang HS, Sattler M, Itzen A (2020)
Conformational control of small GTPases by AMPylation.
Proceedings of the National Academy of Sciences of the United States of America, Issue 11, Vol. 117, 5772-5781
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Denis M, Softley C, Giuntini S, Gentili M, Ravera E, Parigi G, Fragai M, Popowicz G, Sattler M, Luchinat C, Cerofolini L, Nativi C (2020)
The Photocatalyzed Thiol-ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins.
Chemphyschem : a European journal of chemical physics and physical chemistry, Issue 9, Vol. 21, 863-869
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Göttlicher M, Sattler M, Brönstrup M (2020)
New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC).
ChemMedChem, Issue 5, Vol. 15, 468-470
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Solbak SMØ, Zang J, Narayanan D, Høj LJ, Bucciarelli S, Softley C, Meier S, Langkilde AE, Gotfredsen CH, Sattler M, Bach A (2020)
Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.
Journal of medicinal chemistry, Issue 3, Vol. 63, 1156-1177
DOI: 10.1021/acs.jmedchem.9b01492, PubMed: 31922756

Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B (2020)
Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action.
Angewandte Chemie (International ed. in English), Issue 14, Vol. 59, 5771-5781
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Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM (2020)
Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
Journal of medicinal chemistry, Issue 2, Vol. 63, 847-879
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Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M (2019)
FSP1 is a glutathione-independent ferroptosis suppressor.
Nature, Issue 7784, Vol. 575, 693-698
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Jagtap PKA, Asami S, Sippel C, Kaila VRI, Hausch F, Sattler M (2019)
Corrigendum: Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States.
Angewandte Chemie (International ed. in English), Issue 39, Vol. 58, 13619
DOI: 10.1002/anie.201908888, PubMed: 31549791

Meier S, Bohnacker S, Klose CJ, Lopez A, Choe CA, Schmid PWN, Bloemeke N, Rührnößl F, Haslbeck M, Bieren JE, Sattler M, Huang PS, Feige MJ (2019)
The molecular basis of chaperone-mediated interleukin 23 assembly control.
Nature communications, Issue 1, Vol. 10, 4121
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Girstmair H, Tippel F, Lopez A, Tych K, Stein F, Haberkant P, Schmid PWN, Helm D, Rief M, Sattler M, Buchner J (2019)
The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range.
Nature communications, Issue 1, Vol. 10, 3626
DOI: 10.1038/s41467-019-11518-w, PubMed: 31399574

Kalel VC, Li M, Gaussmann S, Delhommel F, Schäfer AB, Tippler B, Jung M, Maier R, Oeljeklaus S, Schliebs W, Warscheid B, Sattler M, Erdmann R (2019)
Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.
Biochimica et biophysica acta. Molecular cell research, Issue 12, Vol. 1866, 118520
DOI: 10.1016/j.bbamcr.2019.07.015, PubMed: 31369765

Lingaraju M, Johnsen D, Schlundt A, Langer LM, Basquin J, Sattler M, Heick Jensen T, Falk S, Conti E (2019)
The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
Nature communications, Issue 1, Vol. 10, 3393
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Jones AN, Sattler M (2019)
Challenges and perspectives for structural biology of lncRNAs-the example of the Xist lncRNA A-repeats.
Journal of molecular cell biology, Issue 10, Vol. 11, 845-859
DOI: 10.1093/jmcb/mjz086, PubMed: 31336384

Kinting S, Li Y, Forstner M, Delhommel F, Sattler M, Griese M (2019)
Potentiation of ABCA3 lipid transport function by ivacaftor and genistein.
Journal of cellular and molecular medicine, Issue 8, Vol. 23, 5225-5234
DOI: 10.1111/jcmm.14397, PubMed: 31210424

von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E (2019)
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
The Journal of experimental medicine, Issue 7, Vol. 216, 1700-1723
DOI: 10.1084/jem.20181762, PubMed: 31126966

Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A (2019)
Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.
Nature communications, Issue 1, Vol. 10, 2266
DOI: 10.1038/s41467-019-09769-8, PubMed: 31118463

Jagtap PKA, Asami S, Sippel C, Kaila VRI, Hausch F, Sattler M (2019)
Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States.
Angewandte Chemie (International ed. in English), Issue 28, Vol. 58, 9429-9433
DOI: 10.1002/anie.201902994, PubMed: 31100184

Tripsianes K, Schütz U, Emmanouilidis L, Gemmecker G, Sattler M (2019)
Selective isotope labeling for NMR structure determination of proteins in complex with unlabeled ligands.
Journal of biomolecular NMR, Issue 3-4, Vol. 73, 183-189
DOI: 10.1007/s10858-019-00241-9, PubMed: 31041647

Ostertag MS, Hutwelker W, Plettenburg O, Sattler M, Popowicz GM (2019)
Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
Journal of molecular biology, Issue 11, Vol. 431, 2213-2221
DOI: 10.1016/j.jmb.2019.04.017, PubMed: 31026449

Heber S, Gáspár I, Tants JN, Günther J, Moya SMF, Janowski R, Ephrussi A, Sattler M, Niessing D (2019)
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
Nature communications, Issue 1, Vol. 10, 1659
DOI: 10.1038/s41467-019-09655-3, PubMed: 30971701

Pabis M, Corsini L, Vincendeau M, Tripsianes K, Gibson TJ, Brack-Werner R, Sattler M (2019)
Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.
Nucleic acids research, Issue 9, Vol. 47, 4859-4871
DOI: 10.1093/nar/gkz185, PubMed: 30892606

Schopf FH, Huber EM, Dodt C, Lopez A, Biebl MM, Rutz DA, Mühlhofer M, Richter G, Madl T, Sattler M, Groll M, Buchner J (2019)
The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.
Molecular cell, Issue 1, Vol. 74, 73-87.e8
DOI: 10.1016/j.molcel.2019.02.011, PubMed: 30876805

Tan H, Su W, Zhang W, Wang P, Sattler M, Zou P (2018)
Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins.
Current pharmaceutical design, Issue 41, Vol. 24, 4932-4946
DOI: 10.2174/1381612825666190206105232, PubMed: 30727869

Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT (2019)
Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465.
Diabetes, Issue 3, Vol. 68, 676
DOI: 10.2337/db19-er03a, PubMed: 30635274

Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J (2019)
Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.
The EMBO journal, Issue 2, Vol. 38, e99876
DOI: 10.15252/embj.201899876, PubMed: 30530478

Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC (2018)
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Journal of medicinal chemistry, Issue 24, Vol. 61, 11144-11157
DOI: 10.1021/acs.jmedchem.8b01224, PubMed: 30525586

Kalel VC, Mäser P, Sattler M, Erdmann R, Popowicz GM (2018)
Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development.
Current opinion in microbiology, Vol. 46, 116-122
DOI: 10.1016/j.mib.2018.11.003, PubMed: 30481613

Ostertag MS, Messias AC, Sattler M, Popowicz GM (2019)
The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
Structure (London, England : 1993), Issue 2, Vol. 27, 327-334.e3
DOI: 10.1016/j.str.2018.10.005, PubMed: 30449689

Pabis M, Popowicz GM, Stehle R, Fernández-Ramos D, Asami S, Warner L, García-Mauriño SM, Schlundt A, Martínez-Chantar ML, Díaz-Moreno I, Sattler M (2019)
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs.
Nucleic acids research, Issue 2, Vol. 47, 1011-1029
DOI: 10.1093/nar/gky1138, PubMed: 30418581

Harrison L, Schriever SC, Feuchtinger A, Kyriakou E, Baumann P, Pfuhlmann K, Messias AC, Walch A, Tschöp MH, Pfluger PT (2019)
Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice.
International journal of obesity (2005), Issue 6, Vol. 43, 1305-1318
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Nature communications, Issue 1, Vol. 9, 3810
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Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT (2018)
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.
Diabetes, Issue 11, Vol. 67, 2456-2465
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Brenke JK, Popowicz GM, Schorpp K, Rothenaigner I, Roesner M, Meininger I, Kalinski C, Ringelstetter L, R'kyek O, Jürjens G, Vincendeau M, Plettenburg O, Sattler M, Krappmann D, Hadian K (2018)
Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.
The Journal of biological chemistry, Issue 34, Vol. 293, 13191-13203
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Kooshapur H, Choudhury NR, Simon B, Mühlbauer M, Jussupow A, Fernandez N, Jones AN, Dallmann A, Gabel F, Camilloni C, Michlewski G, Caceres JF, Sattler M (2018)
Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.
Nature communications, Issue 1, Vol. 9, 2479
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Iuso A, Wiersma M, Schüller HJ, Pode-Shakked B, Marek-Yagel D, Grigat M, Schwarzmayr T, Berutti R, Alhaddad B, Kanon B, Grzeschik NA, Okun JG, Perles Z, Salem Y, Barel O, Vardi A, Rubinshtein M, Tirosh T, Dubnov-Raz G, Messias AC, Terrile C, Barshack I, Volkov A, Avivi C, Eyal E, Mastantuono E, Kumbar M, Abudi S, Braunisch M, Strom TM, Meitinger T, Hoffmann GF, Prokisch H, Haack TB, Brundel BJJM, Haas D, Sibon OCM, Anikster Y (2018)
Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy.
American journal of human genetics, Issue 6, Vol. 102, 1018-1030
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Ghosh D, Koch U, Hadian K, Sattler M, Tetko IV (2018)
Luciferase Advisor: High-Accuracy Model To Flag False Positive Hits in Luciferase HTS Assays.
Journal of chemical information and modeling, Issue 5, Vol. 58, 933-942
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Rutz DA, Luo Q, Freiburger L, Madl T, Kaila VRI, Sattler M, Buchner J (2018)
A switch point in the molecular chaperone Hsp90 responding to client interaction.
Nature communications, Issue 1, Vol. 9, 1472
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Sutandy FXR, Ebersberger S, Huang L, Busch A, Bach M, Kang HS, Fallmann J, Maticzka D, Backofen R, Stadler PF, Zarnack K, Sattler M, Legewie S, König J (2018)
In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors.
Genome research, Issue 5, Vol. 28, 699-713
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Tomala MD, Magiera-Mularz K, Kubica K, Krzanik S, Zieba B, Musielak B, Pustula M, Popowicz GM, Sattler M, Dubin G, Skalniak L, Holak TA (2018)
Identification of small-molecule inhibitors of USP2a.
European journal of medicinal chemistry, Vol. 150, 261-267
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Asami S, Kallies W, Günther JC, Stavropoulou M, Glaser SJ, Sattler M (2018)
Ultrashort Broadband Cooperative Pulses for Multidimensional Biomolecular NMR Experiments.
Angewandte Chemie (International ed. in English), Issue 44, Vol. 57, 14498-14502
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Colaluca IN, Basile A, Freiburger L, D'Uva V, Disalvatore D, Vecchi M, Confalonieri S, Tosoni D, Cecatiello V, Malabarba MG, Yang CJ, Kainosho M, Sattler M, Mapelli M, Pece S, Di Fiore PP (2018)
A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
The Journal of cell biology, Issue 2, Vol. 217, 745-762
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Tants JN, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, Juen M, Hartlmüller C, Böttcher R, Kunzelmann S, Lange O, Kreutz C, Förstemann K, Sattler M (2017)
Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.
Nucleic acids research, Issue 21, Vol. 45, 12536-12550
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Supekar S, Papageorgiou AC, Gemmecker G, Peltzer R, Johansson MP, Tripsianes K, Sattler M, Kaila VRI (2018)
Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain.
Angewandte Chemie (International ed. in English), Issue 2, Vol. 57, 486-490
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Falk S, Tants JN, Basquin J, Thoms M, Hurt E, Sattler M, Conti E (2017)
Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53.
RNA (New York, N.Y.), Issue 12, Vol. 23, 1780-1787
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Stiegler SC, Rübbelke M, Korotkov VS, Weiwad M, John C, Fischer G, Sieber SA, Sattler M, Buchner J (2017)
A chemical compound inhibiting the Aha1-Hsp90 chaperone complex.
The Journal of biological chemistry, Issue 41, Vol. 292, 17073-17083
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Tan H, Su W, Wang P, Zhang W, Sattler M, Zou P (2017)
Expression and purification of a difficult sarcomeric protein: Telethonin.
Protein expression and purification, Vol. 140, 74-80
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Sánchez-Rico C, Voith von Voithenberg L, Warner L, Lamb DC, Sattler M (2017)
Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany), Issue 57, Vol. 23, 14267-14277
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Hartlmüller C, Günther JC, Wolter AC, Wöhnert J, Sattler M, Madl T (2017)
RNA structure refinement using NMR solvent accessibility data.
Scientific reports, Issue 1, Vol. 7, 5393
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Kalel VC, Emmanouilidis L, Dawidowski M, Schliebs W, Sattler M, Popowicz GM, Erdmann R (2017)
Inhibitors of glycosomal protein import provide new leads against trypanosomiasis.
Microbial cell (Graz, Austria), Issue 7, Vol. 4, 229-232
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Sonntag M, Jagtap PKA, Simon B, Appavou MS, Geerlof A, Stehle R, Gabel F, Hennig J, Sattler M (2017)
Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.
Angewandte Chemie (International ed. in English), Issue 32, Vol. 56, 9322-9325
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Schlundt A, Buchner S, Janowski R, Heydenreich T, Heermann R, Lassak J, Geerlof A, Stehle R, Niessing D, Jung K, Sattler M (2017)
Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.
Scientific reports, Issue 1, Vol. 7, 1051
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Schlundt A, Tants JN, Sattler M (2017)
Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition.
Methods (San Diego, Calif.), Vol. 118-119, 119-136
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Emmanouilidis L, Schütz U, Tripsianes K, Madl T, Radke J, Rucktäschel R, Wilmanns M, Schliebs W, Erdmann R, Sattler M (2017)
Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.
Nature communications, Vol. 8, 14635
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Edelmann FT, Schlundt A, Heym RG, Jenner A, Niedner-Boblenz A, Syed MI, Paillart JC, Stehle R, Janowski R, Sattler M, Jansen RP, Niessing D (2017)
Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.
Nature structural & molecular biology, Issue 2, Vol. 24, 152-161
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Mourão A, Bonnal S, Soni K, Warner L, Bordonné R, Valcárcel J, Sattler M (2016)
Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation.
eLife, Vol. 5
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Voith von Voithenberg L, Sánchez-Rico C, Kang HS, Madl T, Zanier K, Barth A, Warner LR, Sattler M, Lamb DC (2016)
Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.
Proceedings of the National Academy of Sciences of the United States of America, Issue 46, Vol. 113, E7169-E7175
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Jagtap PK, Garg D, Kapp TG, Will CL, Demmer O, Lührmann R, Kessler H, Sattler M (2016)
Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing.
Journal of medicinal chemistry, Issue 22, Vol. 59, 10190-10197
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Zierer BK, Rübbelke M, Tippel F, Madl T, Schopf FH, Rutz DA, Richter K, Sattler M, Buchner J (2016)
Importance of cycle timing for the function of the molecular chaperone Hsp90.
Nature structural & molecular biology, Issue 11, Vol. 23, 1020-1028
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Subramaniam S, Erler A, Fu J, Kranz A, Tang J, Gopalswamy M, Ramakrishnan S, Keller A, Grundmeier G, Müller D, Sattler M, Stewart AF (2016)
DNA annealing by Redβ is insufficient for homologous recombination and the additional requirements involve intra- and inter-molecular interactions.
Scientific reports, Vol. 6, 34525
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Delaforge E, Milles S, Huang JR, Bouvier D, Jensen MR, Sattler M, Hart DJ, Blackledge M (2016)
Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions.
Frontiers in molecular biosciences, Vol. 3, 54
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Dallmann A, Beribisky AV, Gnerlich F, Rübbelke M, Schiesser S, Carell T, Sattler M (2016)
Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex.
Chemistry (Weinheim an der Bergstrasse, Germany), Issue 43, Vol. 22, 15350-15359
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Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A, Gloeckner CJ (2016)
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Proceedings of the National Academy of Sciences of the United States of America, Issue 30, Vol. 113, E4357-66
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Zheng X, Ramani A, Soni K, Gottardo M, Zheng S, Ming Gooi L, Li W, Feng S, Mariappan A, Wason A, Widlund P, Pozniakovsky A, Poser I, Deng H, Ou G, Riparbelli M, Giuliano C, Hyman AA, Sattler M, Gopalakrishnan J, Li H (2016)
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.
Nature communications, Vol. 7, 11874
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Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M (2016)
Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Nature communications, Vol. 7, 11032
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Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H (2016)
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.
Scientific reports, Vol. 6, 22540
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Jung B, Padula D, Burtscher I, Landerer C, Lutter D, Theis F, Messias AC, Geerlof A, Sattler M, Kremmer E, Boldt K, Ueffing M, Lickert H (2016)
Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
PloS one, Issue 2, Vol. 11, e0149477
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Schlundt A, Niessing D, Heissmeyer V, Sattler M (2016)
RNA recognition by Roquin in posttranscriptional gene regulation.
Wiley interdisciplinary reviews. RNA, Issue 4, Vol. 7, 455-69
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Carlon A, Ravera E, Hennig J, Parigi G, Sattler M, Luchinat C (2016)
Improved Accuracy from Joint X-ray and NMR Refinement of a Protein-RNA Complex Structure.
Journal of the American Chemical Society, Issue 5, Vol. 138, 1601-10
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Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang HS, Dalgliesh C, Meyer NH, Liu Y, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C (2016)
Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nature communications, Vol. 7, 10355
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Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D (2016)
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.
Scientific reports, Vol. 6, 18934
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Horn A, Hennig J, Ahmed YL, Stier G, Wild K, Sattler M, Sinning I (2015)
Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.
Nature communications, Vol. 6, 8875
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Eckl JM, Scherr MJ, Freiburger L, Daake MA, Sattler M, Richter K (2015)
Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites.
The Journal of biological chemistry, Issue 52, Vol. 290, 30843-54
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Emmanouilidis L, Gopalswamy M, Passon DM, Wilmanns M, Sattler M (2016)
Structural biology of the import pathways of peroxisomal matrix proteins.
Biochimica et biophysica acta, Issue 5, Vol. 1863, 804-13
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Giannopoulou EA, Emmanouilidis L, Sattler M, Dodt G, Wilmanns M (2016)
Towards the molecular mechanism of the integration of peroxisomal membrane proteins.
Biochimica et biophysica acta, Issue 5, Vol. 1863, 863-9
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Freiburger L, Sonntag M, Hennig J, Li J, Zou P, Sattler M (2015)
Efficient segmental isotope labeling of multi-domain proteins using Sortase A.
Journal of biomolecular NMR, Issue 1, Vol. 63, 1-8
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Xu T, Brandmaier S, Messias AC, Herder C, Draisma HH, Demirkan A, Yu Z, Ried JS, Haller T, Heier M, Campillos M, Fobo G, Stark R, Holzapfel C, Adam J, Chi S, Rotter M, Panni T, Quante AS, He Y, Prehn C, Roemisch-Margl W, Kastenmüller G, Willemsen G, Pool R, Kasa K, van Dijk KW, Hankemeier T, Meisinger C, Thorand B, Ruepp A, Hrabé de Angelis M, Li Y, Wichmann HE, Stratmann B, Strauch K, Metspalu A, Gieger C, Suhre K, Adamski J, Illig T, Rathmann W, Roden M, Peters A, van Duijn CM, Boomsma DI, Meitinger T, Wang-Sattler R (2015)
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.
Diabetes care, Issue 10, Vol. 38, 1858-67
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Haslbeck V, Drazic A, Eckl JM, Alte F, Helmuth M, Popowicz G, Schmidt W, Braun F, Weiwad M, Fischer G, Gemmecker G, Sattler M, Striggow F, Groll M, Richter K (2015)
Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Bioscience reports, Issue 3, Vol. 35
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Meyer NH, Mayerhofer H, Tripsianes K, Blindow S, Barths D, Mewes A, Weimar T, Köhli T, Bade S, Madl T, Frey A, Haas H, Mueller-Dieckmann J, Sattler M, Schramm G (2015)
A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation.
The Journal of biological chemistry, Issue 36, Vol. 290, 22111-26
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Hennig J, Warner LR, Simon B, Geerlof A, Mackereth CD, Sattler M (2015)
Structural Analysis of Protein-RNA Complexes in Solution Using NMR Paramagnetic Relaxation Enhancements.
Methods in enzymology, Vol. 558, 333-362
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Hennig J, Sattler M (2015)
Deciphering the protein-RNA recognition code: combining large-scale quantitative methods with structural biology.
BioEssays : news and reviews in molecular, cellular and developmental biology, Issue 8, Vol. 37, 899-908
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Friberg A, Thumann S, Hennig J, Zou P, Nössner E, Ling PD, Sattler M, Kempkes B (2015)
The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation.
PLoS pathogens, Issue 5, Vol. 11, e1004910
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Buchner S, Schlundt A, Lassak J, Sattler M, Jung K (2015)
Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli.
Journal of molecular biology, Issue 15, Vol. 427, 2548-2561
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Anosova I, Melnik S, Tripsianes K, Kateb F, Grummt I, Sattler M (2015)
A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.
Nucleic acids research, Issue 10, Vol. 43, 5208-20
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Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A (2015)
Structural Characterization of LRRK2 Inhibitors.
Journal of medicinal chemistry, Issue 9, Vol. 58, 3751-6
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Sattler M (2015)
Dynamic RNA world.
RNA (New York, N.Y.), Issue 4, Vol. 21, 727-8
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Riebold M, Kozany C, Freiburger L, Sattler M, Buchfelder M, Hausch F, Stalla GK, Paez-Pereda M (2015)
A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.
Nature medicine, Issue 3, Vol. 21, 276-80
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Dallmann A, Sattler M (2014)
Detection of hydrogen bonds in dynamic regions of RNA by NMR spectroscopy.
Current protocols in nucleic acid chemistry, Vol. 59, 7.22.1-19
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Hennig J, Gebauer F, Sattler M (2014)
Breaking the protein-RNA recognition code.
Cell cycle (Georgetown, Tex.), Issue 23, Vol. 13, 3619-20
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Holzmeister C, Gaupels F, Geerlof A, Sarioglu H, Sattler M, Durner J, Lindermayr C (2015)
Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration.
Journal of experimental botany, Issue 3, Vol. 66, 989-99
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Zierer BK, Weiwad M, Rübbelke M, Freiburger L, Fischer G, Lorenz OR, Sattler M, Richter K, Buchner J (2014)
Artificial accelerators of the molecular chaperone Hsp90 facilitate rate-limiting conformational transitions.
Angewandte Chemie (International ed. in English), Issue 45, Vol. 53, 12257-62
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Hennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M (2014)
Structural basis for the assembly of the Sxl-Unr translation regulatory complex.
Nature, Issue 7526, Vol. 515, 287-90
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Tripsianes K, Friberg A, Barrandon C, Brooks M, van Tilbeurgh H, Seraphin B, Sattler M (2014)
A novel protein-protein interaction in the RES (REtention and Splicing) complex.
The Journal of biological chemistry, Issue 41, Vol. 289, 28640-50
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Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, Sattler M (2014)
Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Nature structural & molecular biology, Issue 8, Vol. 21, 671-8
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Göbl C, Madl T, Simon B, Sattler M (2014)
NMR approaches for structural analysis of multidomain proteins and complexes in solution.
Progress in nuclear magnetic resonance spectroscopy, Vol. 80, 26-63
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Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J (2014)
The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.
Proceedings of the National Academy of Sciences of the United States of America, Issue 22, Vol. 111, 8155-60
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Huang JR, Warner LR, Sanchez C, Gabel F, Madl T, Mackereth CD, Sattler M, Blackledge M (2014)
Transient electrostatic interactions dominate the conformational equilibrium sampled by multidomain splicing factor U2AF65: a combined NMR and SAXS study.
Journal of the American Chemical Society, Issue 19, Vol. 136, 7068-76
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Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmüller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, Gloeckner CJ (2014)
Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
Molecular and cellular biology, Issue 12, Vol. 34, 2147-61
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Hennig J, Sattler M (2014)
The dynamic duo: combining NMR and small angle scattering in structural biology.
Protein science : a publication of the Protein Society, Issue 6, Vol. 23, 669-82
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Wang I, Hennig J, Jagtap PK, Sonntag M, Valcárcel J, Sattler M (2014)
Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.
Nucleic acids research, Issue 9, Vol. 42, 5949-66
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Schilling F, Warner LR, Gershenzon NI, Skinner TE, Sattler M, Glaser SJ (2014)
Next-generation heteronuclear decoupling for high-field biomolecular NMR spectroscopy.
Angewandte Chemie (International ed. in English), Issue 17, Vol. 53, 4475-9
DOI: 10.1002/anie.201400178, PubMed: 24623579

Lorenz OR, Freiburger L, Rutz DA, Krause M, Zierer BK, Alvira S, Cuéllar J, Valpuesta JM, Madl T, Sattler M, Buchner J (2014)
Modulation of the Hsp90 chaperone cycle by a stringent client protein.
Molecular cell, Issue 6, Vol. 53, 941-53
DOI: 10.1016/j.molcel.2014.02.003, PubMed: 24613341

Tripsianes K, Chu NK, Friberg A, Sattler M, Becker CF (2014)
Studying weak and dynamic interactions of posttranslationally modified proteins using expressed protein ligation.
ACS chemical biology, Issue 2, Vol. 9, 347-52
DOI: 10.1021/cb400723j, PubMed: 24299430

Neuhaus A, Kooshapur H, Wolf J, Meyer NH, Madl T, Saidowsky J, Hambruch E, Lazam A, Jung M, Sattler M, Schliebs W, Erdmann R (2014)
A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.
The Journal of biological chemistry, Issue 1, Vol. 289, 437-48
DOI: 10.1074/jbc.M113.499707, PubMed: 24235149

Kang C, Ye H, Chia J, Choi BH, Dhe-Paganon S, Simon B, Schütz U, Sattler M, Yoon HS (2013)
Functional role of the flexible N-terminal extension of FKBP38 in catalysis.
Scientific reports, Vol. 3, 2985
DOI: 10.1038/srep02985, PubMed: 24145868

Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G (2013)
Structural features of Argonaute-GW182 protein interactions.
Proceedings of the National Academy of Sciences of the United States of America, Issue 40, Vol. 110, E3770-9
DOI: 10.1073/pnas.1308510110, PubMed: 24043833

Zeitler B, Herrera Diaz A, Dangel A, Thellmann M, Meyer H, Sattler M, Lindermayr C (2013)
De-novo design of antimicrobial peptides for plant protection.
PloS one, Issue 8, Vol. 8, e71687
DOI: 10.1371/journal.pone.0071687, PubMed: 23951222

Dallmann A, Simon B, Duszczyk MM, Kooshapur H, Pardi A, Bermel W, Sattler M (2013)
Efficient detection of hydrogen bonds in dynamic regions of RNA by sensitivity-optimized NMR pulse sequences.
Angewandte Chemie (International ed. in English), Issue 40, Vol. 52, 10487-90
DOI: 10.1002/anie.201304391, PubMed: 23946052

Kadam RU, Garg D, Schwartz J, Visini R, Sattler M, Stocker A, Darbre T, Reymond JL (2013)
CH-π "T-shape" interaction with histidine explains binding of aromatic galactosides to Pseudomonas aeruginosa lectin LecA.
ACS chemical biology, Issue 9, Vol. 8, 1925-30
DOI: 10.1021/cb400303w, PubMed: 23869965

Müller R, Gräwert MA, Kern T, Madl T, Peschek J, Sattler M, Groll M, Buchner J (2013)
High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.
Proceedings of the National Academy of Sciences of the United States of America, Issue 25, Vol. 110, 10183-8
DOI: 10.1073/pnas.1300547110, PubMed: 23733956

Gräber M, Hell M, Gröst C, Friberg A, Sperl B, Sattler M, Berg T (2013)
Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells.
Angewandte Chemie (International ed. in English), Issue 16, Vol. 52, 4487-91
DOI: 10.1002/anie.201208889, PubMed: 23512547

Hennig J, Wang I, Sonntag M, Gabel F, Sattler M (2013)
Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.
Journal of biomolecular NMR, Issue 1, Vol. 56, 17-30
DOI: 10.1007/s10858-013-9719-9, PubMed: 23456097

Garg D, Beribisky AV, Ponterini G, Ligabue A, Marverti G, Martello A, Costi MP, Sattler M, Wade RC (2013)
Translational repression of thymidylate synthase by targeting its mRNA.
Nucleic acids research, Issue 7, Vol. 41, 4159-70
DOI: 10.1093/nar/gkt098, PubMed: 23423353

Kateb F, Perrin H, Tripsianes K, Zou P, Spadaccini R, Bottomley M, Franzmann TM, Buchner J, Ansieau S, Sattler M (2013)
Structural and functional analysis of the DEAF-1 and BS69 MYND domains.
PloS one, Issue 1, Vol. 8, e54715
DOI: 10.1371/journal.pone.0054715, PubMed: 23372760

Zeitler B, Bernhard A, Meyer H, Sattler M, Koop HU, Lindermayr C (2013)
Production of a de-novo designed antimicrobial peptide in Nicotiana benthamiana.
Plant molecular biology, Issue 3, Vol. 81, 259-72
DOI: 10.1007/s11103-012-9996-9, PubMed: 23242916

Zhang Y, Madl T, Bagdiul I, Kern T, Kang HS, Zou P, Mäusbacher N, Sieber SA, Krämer A, Sattler M (2013)
Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition.
Nucleic acids research, Issue 2, Vol. 41, 1343-54
DOI: 10.1093/nar/gks1097, PubMed: 23175611

Wang-Sattler R, Yu Z, Herder C, Messias AC, Floegel A, He Y, Heim K, Campillos M, Holzapfel C, Thorand B, Grallert H, Xu T, Bader E, Huth C, Mittelstrass K, Döring A, Meisinger C, Gieger C, Prehn C, Roemisch-Margl W, Carstensen M, Xie L, Yamanaka-Okumura H, Xing G, Ceglarek U, Thiery J, Giani G, Lickert H, Lin X, Li Y, Boeing H, Joost HG, de Angelis MH, Rathmann W, Suhre K, Prokisch H, Peters A, Meitinger T, Roden M, Wichmann HE, Pischon T, Adamski J, Illig T (2012)
Novel biomarkers for pre-diabetes identified by metabolomics.
Molecular systems biology, Vol. 8, 615
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Mathioudakis N, Palencia A, Kadlec J, Round A, Tripsianes K, Sattler M, Pillai RS, Cusack S (2012)
The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors.
RNA (New York, N.Y.), Issue 11, Vol. 18, 2056-72
DOI: 10.1261/rna.034181.112, PubMed: 22996915

Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S (2012)
In support of the BMRB.
Nature structural & molecular biology, Issue 9, Vol. 19, 854-60
DOI: 10.1038/nsmb.2371, PubMed: 22955930

Mackereth CD, Sattler M (2012)
Dynamics in multi-domain protein recognition of RNA.
Current opinion in structural biology, Issue 3, Vol. 22, 287-96
DOI: 10.1016/j.sbi.2012.03.013, PubMed: 22516180

Tavanez JP, Madl T, Kooshapur H, Sattler M, Valcárcel J (2012)
hnRNP A1 proofreads 3' splice site recognition by U2AF.
Molecular cell, Issue 3, Vol. 45, 314-29
DOI: 10.1016/j.molcel.2011.11.033, PubMed: 22325350

Holdermann I, Meyer NH, Round A, Wild K, Sattler M, Sinning I (2012)
Chromodomains read the arginine code of post-translational targeting.
Nature structural & molecular biology, Issue 2, Vol. 19, 260-3
DOI: 10.1038/nsmb.2196, PubMed: 22231402

Tripsianes K, Madl T, Machyna M, Fessas D, Englbrecht C, Fischer U, Neugebauer KM, Sattler M (2011)
Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.
Nature structural & molecular biology, Issue 12, Vol. 18, 1414-20
DOI: 10.1038/nsmb.2185, PubMed: 22101937

Liokatis S, Edlich C, Soupsana K, Giannios I, Panagiotidou P, Tripsianes K, Sattler M, Georgatos SD, Politou AS (2012)
Solution structure and molecular interactions of lamin B receptor Tudor domain.
The Journal of biological chemistry, Issue 2, Vol. 287, 1032-42
DOI: 10.1074/jbc.M111.281303, PubMed: 22052904

Duszczyk MM, Wutz A, Rybin V, Sattler M (2011)
The Xist RNA A-repeat comprises a novel AUCG tetraloop fold and a platform for multimerization.
RNA (New York, N.Y.), Issue 11, Vol. 17, 1973-82
DOI: 10.1261/rna.2747411, PubMed: 21947263

Kadam RU, Bergmann M, Hurley M, Garg D, Cacciarini M, Swiderska MA, Nativi C, Sattler M, Smyth AR, Williams P, Cámara M, Stocker A, Darbre T, Reymond JL (2011)
A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of Pseudomonas aeruginosa biofilms.
Angewandte Chemie (International ed. in English), Issue 45, Vol. 50, 10631-5
DOI: 10.1002/anie.201104342, PubMed: 21919164

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR (2011)
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
Circulation research, Issue 7, Vol. 109, 758-69
DOI: 10.1161/CIRCRESAHA.111.245787, PubMed: 21799151

Duszczyk MM, Sattler M (2012)
¹H, ¹³C, ¹⁵N and ³¹P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation.
Biomolecular NMR assignments, Issue 1, Vol. 6, 75-7
DOI: 10.1007/s12104-011-9328-z, PubMed: 21779925

Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcárcel J, Sattler M (2011)
Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.
Nature, Issue 7356, Vol. 475, 408-11
DOI: 10.1038/nature10171, PubMed: 21753750

Meyer NH, Schramm G, Sattler M (2011)
1H, 13C and 15N chemical shift assignments of IPSEΔNLS.
Biomolecular NMR assignments, Issue 2, Vol. 5, 225-7
DOI: 10.1007/s12104-011-9305-6, PubMed: 21516468

Madl T, Güttler T, Görlich D, Sattler M (2011)
Structural analysis of large protein complexes using solvent paramagnetic relaxation enhancements.
Angewandte Chemie (International ed. in English), Issue 17, Vol. 50, 3993-7
DOI: 10.1002/anie.201007168, PubMed: 21442693

Vojnic E, Mourão A, Seizl M, Simon B, Wenzeck L, Larivière L, Baumli S, Baumgart K, Meisterernst M, Sattler M, Cramer P (2011)
Structure and VP16 binding of the Mediator Med25 activator interaction domain.
Nature structural & molecular biology, Issue 4, Vol. 18, 404-9
DOI: 10.1038/nsmb.1997, PubMed: 21378965

Madl T, Gabel F, Sattler M (2011)
NMR and small-angle scattering-based structural analysis of protein complexes in solution.
Journal of structural biology, Issue 3, Vol. 173, 472-82
DOI: 10.1016/j.jsb.2010.11.004, PubMed: 21074620

Güttler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, Ficner R, Sattler M, Görlich D (2010)
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
Nature structural & molecular biology, Issue 11, Vol. 17, 1367-76
DOI: 10.1038/nsmb.1931, PubMed: 20972448

Tripsianes K, Sattler M (2010)
Repeat recognition.
Structure (London, England : 1993), Issue 10, Vol. 18, 1228-9
DOI: 10.1016/j.str.2010.09.006, PubMed: 20947010

Bhushan S, Meyer H, Starosta AL, Becker T, Mielke T, Berninghausen O, Sattler M, Wilson DN, Beckmann R (2010)
Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide.
Molecular cell, Issue 1, Vol. 40, 138-46
DOI: 10.1016/j.molcel.2010.09.009, PubMed: 20932481

Friberg A, Oddone A, Klymenko T, Müller J, Sattler M (2010)
Structure of an atypical Tudor domain in the Drosophila Polycomblike protein.
Protein science : a publication of the Protein Society, Issue 10, Vol. 19, 1906-16
DOI: 10.1002/pro.476, PubMed: 20669242

Meyer NH, Tripsianes K, Vincendeau M, Madl T, Kateb F, Brack-Werner R, Sattler M (2010)
Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain.
The Journal of biological chemistry, Issue 37, Vol. 285, 28893-901
DOI: 10.1074/jbc.M110.126185, PubMed: 20610388

Madl T, Felli IC, Bertini I, Sattler M (2010)
Structural analysis of protein interfaces from 13C direct-detected paramagnetic relaxation enhancements.
Journal of the American Chemical Society, Issue 21, Vol. 132, 7285-7
DOI: 10.1021/ja1014508, PubMed: 20462243

Mourão A, Varrot A, Mackereth CD, Cusack S, Sattler M (2010)
Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX.
RNA (New York, N.Y.), Issue 6, Vol. 16, 1205-16
DOI: 10.1261/rna.2009910, PubMed: 20430857

Simon B, Madl T, Mackereth CD, Nilges M, Sattler M (2010)
An efficient protocol for NMR-spectroscopy-based structure determination of protein complexes in solution.
Angewandte Chemie (International ed. in English), Issue 11, Vol. 49, 1967-70
DOI: 10.1002/anie.200906147, PubMed: 20148424

Rumpf J, Simon B, Groemping Y, Sattler M (2008)
1H, 13C, and 15N chemical shift assignments for the Eps15-EH2-stonin 2 complex.
Biomolecular NMR assignments, Issue 1, Vol. 2, 55-8
DOI: 10.1007/s12104-008-9083-y, PubMed: 19636924

Corsini L, Sattler M (2008)
Backbone assignment of the UHM domain of Puf60 free and bound to five ligands.
Biomolecular NMR assignments, Issue 2, Vol. 2, 211-4
DOI: 10.1007/s12104-008-9123-7, PubMed: 19636907

Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S (2009)
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
The EMBO journal, Issue 15, Vol. 28, 2293-306
DOI: 10.1038/emboj.2009.175, PubMed: 19556969

Madl T, Sattler M (2009)
Adhesion dance with raver.
Structure (London, England : 1993), Issue 6, Vol. 17, 781-3
DOI: 10.1016/j.str.2009.05.004, PubMed: 19523894

Friberg A, Corsini L, Mourão A, Sattler M (2009)
Structure and ligand binding of the extended Tudor domain of D. melanogaster Tudor-SN.
Journal of molecular biology, Issue 4, Vol. 387, 921-34
DOI: 10.1016/j.jmb.2009.02.018, PubMed: 19232356

Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M (2009)
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
The EMBO journal, Issue 6, Vol. 28, 745-54
DOI: 10.1038/emboj.2009.7, PubMed: 19197237

Duszczyk MM, Zanier K, Sattler M (2008)
A NMR strategy to unambiguously distinguish nucleic acid hairpin and duplex conformations applied to a Xist RNA A-repeat.
Nucleic acids research, Issue 22, Vol. 36, 7068-77
DOI: 10.1093/nar/gkn776, PubMed: 18987004

Bogomolovas J, Simon B, Sattler M, Stier G (2009)
Screening of fusion partners for high yield expression and purification of bioactive viscotoxins.
Protein expression and purification, Issue 1, Vol. 64, 16-23
DOI: 10.1016/j.pep.2008.10.003, PubMed: 18983922

Corsini L, Hothorn M, Stier G, Rybin V, Scheffzek K, Gibson TJ, Sattler M (2009)
Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60.
The Journal of biological chemistry, Issue 1, Vol. 284, 630-639
DOI: 10.1074/jbc.M805395200, PubMed: 18974054

Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K (2008)
Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
EMBO reports, Issue 11, Vol. 9, 1134-40
DOI: 10.1038/embor.2008.188, PubMed: 18833287

Corsini L, Hothorn M, Scheffzek K, Sattler M, Stier G (2008)
Thioredoxin as a fusion tag for carrier-driven crystallization.
Protein science : a publication of the Protein Society, Issue 12, Vol. 17, 2070-9
DOI: 10.1110/ps.037564.108, PubMed: 18780816

Spadaccini R, Perrin H, Bottomley MJ, Ansieau S, Sattler M (2008)
Retraction notice to "Structure and functional analysis of the MYND domain" [J. Mol. Biol. (2006) 358, 498-508].
Journal of molecular biology, Issue 5, Vol. 376, 1523
DOI: 10.1016/j.jmb.2008.01.071, PubMed: 18286714

Rumpf J, Simon B, Jung N, Maritzen T, Haucke V, Sattler M, Groemping Y (2008)
Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.
The EMBO journal, Issue 3, Vol. 27, 558-69
DOI: 10.1038/sj.emboj.7601980, PubMed: 18200045

Black SL, Stanley WA, Filipp FV, Bhairo M, Verma A, Wichmann O, Sattler M, Wilmanns M, Schultz C (2008)
Probing lipid- and drug-binding domains with fluorescent dyes.
Bioorganic & medicinal chemistry, Issue 3, Vol. 16, 1162-73
DOI: 10.1016/j.bmc.2007.10.080, PubMed: 18024138

Corsini L, Bonnal S, Basquin J, Hothorn M, Scheffzek K, Valcárcel J, Sattler M (2007)
U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
Nature structural & molecular biology, Issue 7, Vol. 14, 620-9
DOI: 10.1038/nsmb1260, PubMed: 17589525

Filipp FV, Sattler M (2007)
Conformational plasticity of the lipid transfer protein SCP2.
Biochemistry, Issue 27, Vol. 46, 7980-91
DOI: 10.1021/bi6025616, PubMed: 17566986

Brumbaugh J, Schleifenbaum A, Stier G, Sattler M, Schultz C (2006)
Single- and dual-parameter FRET kinase probes based on pleckstrin.
Nature protocols, Issue 2, Vol. 1, 1044-55
DOI: 10.1038/nprot.2006.177, PubMed: 17406341

Corsini L, Sattler M (2007)
Tudor hooks up with DNA repair.
Nature structural & molecular biology, Issue 2, Vol. 14, 98-9
DOI: 10.1038/nsmb0207-98, PubMed: 17277801

Oddone A, Lorentzen E, Basquin J, Gasch A, Rybin V, Conti E, Sattler M (2007)
Structural and biochemical characterization of the yeast exosome component Rrp40.
EMBO reports, Issue 1, Vol. 8, 63-9
DOI: 10.1038/sj.embor.7400856, PubMed: 17159918

Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M (2006)
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p.
Molecular cell, Issue 5, Vol. 24, 653-663
DOI: 10.1016/j.molcel.2006.10.024, PubMed: 17157249

Messias AC, Harnisch C, Ostareck-Lederer A, Sattler M, Ostareck DH (2006)
The DICE-binding activity of KH domain 3 of hnRNP K is affected by c-Src-mediated tyrosine phosphorylation.
Journal of molecular biology, Issue 3, Vol. 361, 470-81
DOI: 10.1016/j.jmb.2006.06.025, PubMed: 16854432

Soares LM, Zanier K, Mackereth C, Sattler M, Valcárcel J (2006)
Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.
Science (New York, N.Y.), Issue 5782, Vol. 312, 1961-5
DOI: 10.1126/science.1128659, PubMed: 16809543

Lescrinier E, Nauwelaerts K, Zanier K, Poesen K, Sattler M, Herdewijn P (2006)
The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes formation of a unique U-turn motif.
Nucleic acids research, Issue 10, Vol. 34, 2878-86
DOI: 10.1093/nar/gkl081, PubMed: 16738127

Kang CB, Ye H, Vivekanandan S, Simon B, Sattler M, Yoon HS (2006)
Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD).
Journal of biomolecular NMR, Vol. 36 Suppl 1, 37
DOI: 10.1007/s10858-006-9001-5, PubMed: 16718587

Edlich C, Simon B, Sattler M, Muhle-Goll C (2006)
New NMR assignment 1H, 13C, and 15N assignment of the second PH domain of human pleckstrin (234-350).
Journal of biomolecular NMR, Vol. 36 Suppl 1, 21
DOI: 10.1007/s10858-005-6053-x, PubMed: 16642402

Pimienta G, Gabel F, Zanier K, Conti E, Sattler M (2006)
Chemical shift backbone assignments of TAP-N, the 31 kDa cargo-binding region of the protein TAP.
Journal of biomolecular NMR, Vol. 36 Suppl 1, 23
DOI: 10.1007/s10858-006-0002-1, PubMed: 16596343

Spadaccini R, Perrin H, Bottomley MJ, Ansieau S, Sattler M (2006)
Structure and functional analysis of the MYND domain.
Journal of molecular biology, Issue 2, Vol. 358, 498-508
DOI: 10.1016/j.jmb.2006.01.087, PubMed: 16527309

Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M, Musacchio A (2006)
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet.
The EMBO journal, Issue 6, Vol. 25, 1273-84
DOI: 10.1038/sj.emboj.7601033, PubMed: 16525508

Spadaccini R, Reidt U, Dybkov O, Will C, Frank R, Stier G, Corsini L, Wahl MC, Lührmann R, Sattler M (2006)
Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing.
RNA (New York, N.Y.), Issue 3, Vol. 12, 410-25
DOI: 10.1261/rna.2271406, PubMed: 16495236

Gabel F, Simon B, Sattler M (2006)
A target function for quaternary structural refinement from small angle scattering and NMR orientational restraints.
European biophysics journal : EBJ, Issue 4, Vol. 35, 313-27
DOI: 10.1007/s00249-005-0037-3, PubMed: 16416140

Brumbaugh J, Schleifenbaum A, Gasch A, Sattler M, Schultz C (2006)
A dual parameter FRET probe for measuring PKC and PKA activity in living cells.
Journal of the American Chemical Society, Issue 1, Vol. 128, 24-5
DOI: 10.1021/ja0562200, PubMed: 16390103

Vojnic E, Simon B, Strahl BD, Sattler M, Cramer P (2006)
Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription.
The Journal of biological chemistry, Issue 1, Vol. 281, 13-5
DOI: 10.1074/jbc.C500423200, PubMed: 16286474

Lingel A, Simon B, Izaurralde E, Sattler M (2005)
The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.
EMBO reports, Issue 12, Vol. 6, 1149-55
DOI: 10.1038/sj.embor.7400583, PubMed: 16270100

Wiesner S, Hantschel O, Mackereth CD, Superti-Furga G, Sattler M (2005)
NMR Assignment Reveals an alpha-Helical Fold for the F-Actin Binding Domain of Human Bcr-Abl/c-Abl.
Journal of biomolecular NMR, Issue 4, Vol. 32, 335
DOI: 10.1007/s10858-005-8868-x, PubMed: 16211486

Hantschel O, Wiesner S, Güttler T, Mackereth CD, Rix LL, Mikes Z, Dehne J, Görlich D, Sattler M, Superti-Furga G (2005)
Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl.
Molecular cell, Issue 4, Vol. 19, 461-73
DOI: 10.1016/j.molcel.2005.06.030, PubMed: 16109371

Mackereth CD, Simon B, Sattler M (2005)
Extending the size of protein-RNA complexes studied by nuclear magnetic resonance spectroscopy.
Chembiochem : a European journal of chemical biology, Issue 9, Vol. 6, 1578-84
DOI: 10.1002/cbic.200500106, PubMed: 16075426

Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S (2005)
X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids.
Structure (London, England : 1993), Issue 7, Vol. 13, 1055-67
DOI: 10.1016/j.str.2005.04.008, PubMed: 16004877

Markwick PR, Sprangers R, Sattler M (2005)
Local structure and anisotropic backbone dynamics from cross-correlated NMR relaxation in proteins.
Angewandte Chemie (International ed. in English), Issue 21, Vol. 44, 3232-7
DOI: 10.1002/anie.200462495, PubMed: 15844105

Lingel A, Sattler M (2005)
Novel modes of protein-RNA recognition in the RNAi pathway.
Current opinion in structural biology, Issue 1, Vol. 15, 107-15
DOI: 10.1016/j.sbi.2005.01.010, PubMed: 15718141

Edlich C, Stier G, Simon B, Sattler M, Muhle-Goll C (2005)
Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin.
Structure (London, England : 1993), Issue 2, Vol. 13, 277-86
DOI: 10.1016/j.str.2004.11.012, PubMed: 15698571

Bottomley MJ, Stier G, Pennacchini D, Legube G, Simon B, Akhtar A, Sattler M, Musco G (2005)
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease.
The Journal of biological chemistry, Issue 12, Vol. 280, 11505-12
DOI: 10.1074/jbc.M413959200, PubMed: 15649886

Sattler MA, Mtasiwa D, Kiama M, Premji Z, Tanner M, Killeen GF, Lengeler C (2005)
Habitat characterization and spatial distribution of Anopheles sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period.
Malaria journal, Vol. 4, 4
DOI: 10.1186/1475-2875-4-4, PubMed: 15649333

Civera C, Simon B, Stier G, Sattler M, Macias MJ (2005)
Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily.
Proteins, Issue 2, Vol. 58, 354-66
DOI: 10.1002/prot.20320, PubMed: 15573383

Schleifenbaum A, Stier G, Gasch A, Sattler M, Schultz C (2004)
Genetically encoded FRET probe for PKC activity based on pleckstrin.
Journal of the American Chemical Society, Issue 38, Vol. 126, 11786-7
DOI: 10.1021/ja0460155, PubMed: 15382901

Markwick PR, Sattler M (2004)
Site-specific variations of carbonyl chemical shift anisotropies in proteins.
Journal of the American Chemical Society, Issue 37, Vol. 126, 11424-5
DOI: 10.1021/ja047859r, PubMed: 15366873

Peng C, Unger SW, Filipp FV, Sattler M, Szalma S (2004)
Automated evaluation of chemical shift perturbation spectra: New approaches to quantitative analysis of receptor-ligand interaction NMR spectra.
Journal of biomolecular NMR, Issue 4, Vol. 29, 491-504
DOI: 10.1023/B:JNMR.0000034351.37982.9e, PubMed: 15243180

Lingel A, Simon B, Izaurralde E, Sattler M (2004)
NMR assignment of the Drosophila Argonaute2 PAZ domain.
Journal of biomolecular NMR, Issue 3, Vol. 29, 421-2
DOI: 10.1023/B:JNMR.0000032513.15693.04, PubMed: 15213449

Lingel A, Simon B, Izaurralde E, Sattler M (2004)
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain.
Nature structural & molecular biology, Issue 6, Vol. 11, 576-7
DOI: 10.1038/nsmb777, PubMed: 15156196

Messias AC, Sattler M (2004)
Structural basis of single-stranded RNA recognition.
Accounts of chemical research, Issue 5, Vol. 37, 279-87
DOI: 10.1021/ar030034m, PubMed: 15147168

Simon B, Sattler M (2004)
Speeding up biomolecular NMR spectroscopy.
Angewandte Chemie (International ed. in English), Issue 7, Vol. 43, 782-6
DOI: 10.1002/anie.200301680, PubMed: 14767949

Amininasab M, Elmi MM, Endlich N, Endlich K, Parekh N, Naderi-Manesh H, Schaller J, Mostafavi H, Sattler M, Sarbolouki MN, Muhle-Goll C (2004)
Functional and structural characterization of a novel member of the natriuretic family of peptides from the venom of Pseudocerastes persicus.
FEBS letters, Issue 1-3, Vol. 557, 104-8
DOI: 10.1016/s0014-5793(03)01455-8, PubMed: 14741349

Lingel A, Simon B, Izaurralde E, Sattler M (2003)
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain.
Nature, Issue 6965, Vol. 426, 465-9
DOI: 10.1038/nature02123, PubMed: 14615801

Selenko P, Gregorovic G, Sprangers R, Stier G, Rhani Z, Krämer A, Sattler M (2003)
Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP.
Molecular cell, Issue 4, Vol. 11, 965-76
DOI: 10.1016/s1097-2765(03)00115-1, PubMed: 12718882

Surdo PL, Bottomley MJ, Sattler M, Scheffzek K (2003)
Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions.
Molecular endocrinology (Baltimore, Md.), Issue 7, Vol. 17, 1283-95
DOI: 10.1210/me.2002-0409, PubMed: 12702733

Bottomley MJ, Sattler M (2003)
1H, 13C and 15N backbone resonance assignments of the SAND domains from glucocorticoid modulatory element binding proteins-1 and -2.
Journal of biomolecular NMR, Issue 3, Vol. 25, 259-60
DOI: 10.1023/a:1022817817312, PubMed: 12652142

Sprangers R, Groves MR, Sinning I, Sattler M (2003)
High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues.
Journal of molecular biology, Issue 2, Vol. 327, 507-20
DOI: 10.1016/s0022-2836(03)00148-7, PubMed: 12628254

Selenko P, Sattler M (2003)
Switching off the switch.
Structure (London, England : 1993), Issue 2, Vol. 11, 131-2
DOI: 10.1016/s0969-2126(03)00012-1, PubMed: 12575930

Sprangers R, Selenko P, Sattler M, Sinning I, Groves MR (2003)
Definition of domain boundaries and crystallization of the SMN Tudor domain.
Acta crystallographica. Section D, Biological crystallography, Issue Pt 2, Vol. 59, 366-8
DOI: 10.1107/s0907444902021406, PubMed: 12554955

Markwick PR, Sprangers R, Sattler M (2003)
Dynamic effects on j-couplings across hydrogen bonds in proteins.
Journal of the American Chemical Society, Issue 3, Vol. 125, 644-5
DOI: 10.1021/ja028875w, PubMed: 12526659

Simon B, Sattler M (2002)
De novo structure determination from residual dipolar couplings by NMR spectroscopy.
Angewandte Chemie (International ed. in English), Issue 3, Vol. 41, 437-40
DOI: 10.1002/1521-3773(20020201)41:3<437::aid-anie437>3.0.co;2-3, PubMed: 12491371

Wiesner S, Stier G, Sattler M, Macias MJ (2002)
Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40.
Journal of molecular biology, Issue 4, Vol. 324, 807-22
DOI: 10.1016/s0022-2836(02)01145-2, PubMed: 12460579

Douangamath A, Filipp FV, Klein AT, Barnett P, Zou P, Voorn-Brouwer T, Vega MC, Mayans OM, Sattler M, Distel B, Wilmanns M (2002)
Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain.
Molecular cell, Issue 5, Vol. 10, 1007-17
DOI: 10.1016/s1097-2765(02)00749-9, PubMed: 12453410

Kellenberger E, Stier G, Sattler M (2002)
Induced folding of the U2AF35 RRM upon binding to U2AF65.
FEBS letters, Issue 1-3, Vol. 528, 171-6
DOI: 10.1016/s0014-5793(02)03294-5, PubMed: 12297299

Zanier K, Luyten I, Crombie C, Muller B, Schümperli D, Linge JP, Nilges M, Sattler M (2002)
Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression.
RNA (New York, N.Y.), Issue 1, Vol. 8, 29-46
DOI: 10.1017/s1355838202014061, PubMed: 11871659